Malignant Transformation Rate of Oral Submucous Fibrosis: A Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Protocol Registration
2.2. Keywords Selection
2.3. Studies Selection and Data Extraction Process
2.4. Risk of Bias Assessment
2.5. Summary Measures and Methods of Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Study, Year of Study | Cohort Ethnicity [Study Location] | Number of Patients | Number of Patients Diagnosed with Cancer | Mean Age | F:M | Follow Up Period [Years] | Calculated MTR | Reported MTR | Calculated Annual MTR (%) [Reported Annual MTR (%)] | Type of Study |
---|---|---|---|---|---|---|---|---|---|---|
Pindborg et al. [7], 1964 | Indian [India] | 25 | 1 | 41.7 | 1.5:1 | NR | 4.0 | 2.8 | NR [NR] | Pros |
Pindborg et al. [8], 1984 | Indian [India] | 89 | 12 | NR | NR | 8 | 13.5 | 4.5 | 1.7 [0.6] | Ret |
Murti et al. [9], 1985 | Indian [India] | 66 | 5 | NR | NR | 15 | 7.6 | 4.5 | 0.5 [0.3] | Ret |
Shiau & Kwan [14], 1979 | Taiwanese [Taiwan] | 35 | 8 | 40.5 | 1:34 | NR | 22.9 | 23.0 | NR [NR] | Ret |
Liu et al. [15], 1988 | Chinese [China] | 45 | 1 | NR | 1:1.5 | NR | 2.2 | 2.2 | NR [NR] | Pros |
Jian et al. [16], 1989 | Chinese [China] | 29 | 0 | 40.2 | 1:2.5 | NR | 0.0 | 0.0 | NR [NR] | Pros |
Tang et al. [17], 1997 | Chinese [China] | 335 | 4 | 38.6 | 1:3 | NR | 1.2 | 1.2 | NR [NR] | Pros |
Jian et al. [18], 2000 | Chinese [China] | 147 | 3 | NR | 1:5.7 | NR | 2.0 | 2.0 | NR [NR] | Pros |
Gao et al. [19], 2005 | Chinese [China] | 1166 | 20 | 37.6 | 1:5.4 | NR | 1.7 | 1.7 | NR [NR] | Pros |
Hazarey et al. [20], 2007 | Indian [India] | 1000 | 33 | NR | NR | NR | 3.3 | NR | NR [NR] | Pros |
Hsue et al. [21], 2007 | Taiwanese [Taiwan] | 402 | 8 | 47.5 | NR | 10 | 2.0 | 1.9 | 0.2 [0.2] | Ret |
Angadi & Rekha [22], 2011 | Indian [India] | 205 | 24 | 46 | 1:11 | NR | 11.7 | 11.7 | NR [NR] | Ret |
Mohiuddin et al. [23], 2016 | Pakistan [Pakistan] | 1774 | 472 | NR | 3:1 | NR | 26.6 | 26.6 | NR [NR] | Ret |
Yang et al. [24], 2017 | Taiwanese [Taiwan] | 778 | 71 | 41.8 | 1:6.7 | 6 | 9.1 | 9.1 | 1.5 [NR] | Ret |
Chuang et al. [25], 2018 | Taiwanese [Taiwan] | 2333 | 114 | 45 | NR | 5.7 | 4.9 | 0.9 | 0.9 [0.9] | Pros |
Chiang et al. [26], 2020 | Taiwanese [Taiwan] | 87 | 4 | NR | NR | 6.7 | 4.6 | 4.6 | 0.7 [NR] | Pros |
Study/Year | Selection (Score) | Comparability (Score) | Exposure (Score) | Total Score | |||||
---|---|---|---|---|---|---|---|---|---|
Representatives of the Expo Sed Cohort | Selection of the Non-Exposed Cohort | Ascertainment of Exposure | Outcome of Interest Was not Present at Start of Study | Based on the Design or Analysis | Assessment of Outcome | Follow-Up Long Enough for Outcomes to Occur | Adequacy of Follow-UP of Cohorts | ||
Pindborg et al. [7], 1964 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 3 |
Pindborg et al. [8], 1984 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 4 |
Murti et al. [9], 1985 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 4 |
Shiau & Kwan [14], 1979 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 3 |
Liu et al. [15], 1988 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 5 |
Jian et al. [16], 1989 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 5 |
Tang et al. [17], 1997 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 5 |
Jian et al. [18], 2000 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 5 |
Gao et al. [19], 2005 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 5 |
Hazarey et al. [20], 2007 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 5 |
Hsue et al. [21], 2007 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 6 |
Angadi & Rekha [22], 2011 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 5 |
Mohiuddin et al. [23], 2016 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 5 |
Yang et al. [24], 2019 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 6 |
Chuang et al. [25], 2018 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 7 |
Chiang et al. [26], 2020 | 1 | 0 | 1 | 1 | 2 | 1 | 1 | 1 | 8 |
India | China |
---|---|
Smokeless tobacco | Betel fruit (husk and leaf) |
Betel leaves | Peppermint |
Spices | Gelatine |
Molasses | Lime |
Catechu | Calcium carbonate |
Slaked lime | Calcium hydroxide |
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Murthy, V.; Mylonas, P.; Carey, B.; Yogarajah, S.; Farnell, D.; Addison, O.; Cook, R.; Escudier, M.; Diniz-Freitas, M.; Limeres, J.; et al. Malignant Transformation Rate of Oral Submucous Fibrosis: A Systematic Review and Meta-Analysis. J. Clin. Med. 2022, 11, 1793. https://doi.org/10.3390/jcm11071793
Murthy V, Mylonas P, Carey B, Yogarajah S, Farnell D, Addison O, Cook R, Escudier M, Diniz-Freitas M, Limeres J, et al. Malignant Transformation Rate of Oral Submucous Fibrosis: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2022; 11(7):1793. https://doi.org/10.3390/jcm11071793
Chicago/Turabian StyleMurthy, Vignesh, Petros Mylonas, Barbara Carey, Sangeetha Yogarajah, Damian Farnell, Owen Addison, Richard Cook, Michael Escudier, Marcio Diniz-Freitas, Jacobo Limeres, and et al. 2022. "Malignant Transformation Rate of Oral Submucous Fibrosis: A Systematic Review and Meta-Analysis" Journal of Clinical Medicine 11, no. 7: 1793. https://doi.org/10.3390/jcm11071793
APA StyleMurthy, V., Mylonas, P., Carey, B., Yogarajah, S., Farnell, D., Addison, O., Cook, R., Escudier, M., Diniz-Freitas, M., Limeres, J., Monteiro, L., Silva, L., Fricain, J. -C., Catros, S., Fenelon, M., Lodi, G., Lombardi, N., Brailo, V., Ariyaratnam, R., ... Albuquerque, R. (2022). Malignant Transformation Rate of Oral Submucous Fibrosis: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 11(7), 1793. https://doi.org/10.3390/jcm11071793