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Review

Pathophysiology of Heart Failure: A Role for Peripheral Blood Mononuclear Cells Mitochondrial Dysfunction?

1
University of Strasbourg, Translational Medicine Federation of Strasbourg (FMTS), Faculty of Medicine, Team 3072 “Mitochondria, Oxidative Stress and Muscle Protection”, 11 rue Humann, 67000 Strasbourg, France
2
University Hospital of Strasbourg, Physiology and Functional Exploration Service, 1 Place de l’Hôpital, 67091 Strasbourg, France
3
Internal Medicine, Diabete and Metabolic Diseases Service, University Hospital of Strasbourg, 1 Place de l’Hôpital, 67091 Strasbourg, France
*
Author to whom correspondence should be addressed.
Academic Editor: Rabea Asleh
J. Clin. Med. 2022, 11(3), 741; https://doi.org/10.3390/jcm11030741
Received: 20 December 2021 / Revised: 24 January 2022 / Accepted: 27 January 2022 / Published: 29 January 2022
(This article belongs to the Special Issue Current Challenges and Advances in Heart Failure and Heart Transplant)
Heart failure (HF) is a leading cause of hospitalization in patients aged more than 65 years and is associated with high mortality rates. A better comprehension of its physiopathology is still needed, and, in addition to neurohormonal systems and sodium glucose co-transporter 2 modulations, recent studies focus on the mitochondrial respiration of peripheral blood circulating cells (PBMCs). Thus, cardiovascular metabolic risk factors and cellular switch with an increased neutrophil/lymphocytes ratio might favor the decreased PBMC mitochondrial respiration observed in relation with HF severity. PBMCs are implicated in the immune system function and mitochondrial dysfunction of PBMC, potentially induced by their passage through a damaged heart and by circulating mitoDAMPs, which can lead to a vicious circle, thus sustaining negative cardiac remodeling during HF. This new approach of HF complex pathophysiology appears to be a promising field of research, and further studies on acute and chronic HF with reduced or preserved LVEF are warranted to better understand whether circulating PBMC mitochondrial function and mitoDAMPs follow-ups in HF patients might show diagnosis, prognosis or therapeutic usefulness. View Full-Text
Keywords: heart failure; peripheral blood mononuclear cell; PBMC; mitochondria; oxidative stress; pathophysiology heart failure; peripheral blood mononuclear cell; PBMC; mitochondria; oxidative stress; pathophysiology
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MDPI and ACS Style

Sauer, F.; Riou, M.; Charles, A.-L.; Meyer, A.; Andres, E.; Geny, B.; Talha, S. Pathophysiology of Heart Failure: A Role for Peripheral Blood Mononuclear Cells Mitochondrial Dysfunction? J. Clin. Med. 2022, 11, 741. https://doi.org/10.3390/jcm11030741

AMA Style

Sauer F, Riou M, Charles A-L, Meyer A, Andres E, Geny B, Talha S. Pathophysiology of Heart Failure: A Role for Peripheral Blood Mononuclear Cells Mitochondrial Dysfunction? Journal of Clinical Medicine. 2022; 11(3):741. https://doi.org/10.3390/jcm11030741

Chicago/Turabian Style

Sauer, François, Marianne Riou, Anne-Laure Charles, Alain Meyer, Emmanuel Andres, Bernard Geny, and Samy Talha. 2022. "Pathophysiology of Heart Failure: A Role for Peripheral Blood Mononuclear Cells Mitochondrial Dysfunction?" Journal of Clinical Medicine 11, no. 3: 741. https://doi.org/10.3390/jcm11030741

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