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Article

Effects of Growth Hormone (GH) Supplementation on Dermatoscopic Evolution of Pigmentary Lesions in Children with Growth Hormone Deficiency (GHD)

1
Department of Dermatology, University “G D’Annunzio” University of Chieti-Pescara, 66100 Chieti, Italy
2
Department of Experimental and Clinical Sciences, Biostatistic Laboratory, University “G D’Annunzio” University of Chieti-Pescara, 66100 Chieti, Italy
3
Department of Pediatrics, University “G D’Annunzio” University of Chieti-Pescara, 66100 Chieti, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Masutaka Furue
J. Clin. Med. 2022, 11(3), 736; https://doi.org/10.3390/jcm11030736
Received: 30 December 2021 / Revised: 25 January 2022 / Accepted: 25 January 2022 / Published: 29 January 2022
(This article belongs to the Section Dermatology)
Recent reports have confirmed higher levels of growth hormone (GH) receptor (GHR) transcripts in malignant melanomas (MM), yet the role of GH in the pathogenesis of MM remains controversial. Although melanocytes appear to be hormonally responsive, the effects of GH on MM cells are less clear. A direct correlation between GH administration and the development of melanoma seems possible. Our study aimed to assess whether GH supplementation in children with growth hormone deficiency (GHD) could induce changes in the melanocytic lesions both from a dimensional and dermoscopic point of view. The study population consisted of 14 patients sorted into two groups. The experimental group consisted of seven GHD pediatric patients who underwent dermatological examination with epiluminescence through the use of digital video recording of all melanocytic lesions before and after 12 months of GH supplementation, whilst the control group consisted of seven healthy pediatric patients matched for age, sex and phototype. All patients were evaluated according to auxological and dermatological features. A total of 225 melanocytic lesions were examined in the experimental group and 236 in the control group. Our study shows a significant increase in the mean size values of the lesions in the study group but not in the control group. Increases in the dermoscopic ABCD Score and in BMI correlated to an increase in the size of the melanocytic lesions and the dermoscopic parameters. The increase in SDS Height correlated with ABCD Score changes and with dermoscopic score structures. No differences were found compared to the control group. Dimensional/structural modifications in melanocytic lesions of patients treated with GH were closely related to weight and statural growth and can be considered a normal physiological process induced by GH supplementation. View Full-Text
Keywords: nevi; GH; melanoma nevi; GH; melanoma
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MDPI and ACS Style

Panarese, F.; Gualdi, G.; Di Nicola, M.; Giannini, C.; Polidori, N.; Giuliani, F.; Mohn, A.; Amerio, P. Effects of Growth Hormone (GH) Supplementation on Dermatoscopic Evolution of Pigmentary Lesions in Children with Growth Hormone Deficiency (GHD). J. Clin. Med. 2022, 11, 736. https://doi.org/10.3390/jcm11030736

AMA Style

Panarese F, Gualdi G, Di Nicola M, Giannini C, Polidori N, Giuliani F, Mohn A, Amerio P. Effects of Growth Hormone (GH) Supplementation on Dermatoscopic Evolution of Pigmentary Lesions in Children with Growth Hormone Deficiency (GHD). Journal of Clinical Medicine. 2022; 11(3):736. https://doi.org/10.3390/jcm11030736

Chicago/Turabian Style

Panarese, Fabrizio, Giulio Gualdi, Marta Di Nicola, Cosimo Giannini, Nella Polidori, Federica Giuliani, Angelika Mohn, and Paolo Amerio. 2022. "Effects of Growth Hormone (GH) Supplementation on Dermatoscopic Evolution of Pigmentary Lesions in Children with Growth Hormone Deficiency (GHD)" Journal of Clinical Medicine 11, no. 3: 736. https://doi.org/10.3390/jcm11030736

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