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Volume 11
Issue 24
10.3390/jcm11247532
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Systematic Review
Peer-Review Record

Platelet-Rich Plasma in Chronic Wound Management: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

J. Clin. Med. 2022, 11(24), 7532; https://doi.org/10.3390/jcm11247532
by Fanni Adél Meznerics 1,2, Péter Fehérvári 2,3, Fanni Dembrovszky 2,4, Kata Dorottya Kovács 1, Lajos Vince Kemény 1,5, Dezső Csupor 2,4,6, Péter Hegyi 2,4,7 and András Bánvölgyi 1,*
Reviewer 1:
Latif Sumera
Reviewer 2:
Wen‐Kuan Chiu
Reviewer 3: Anonymous
J. Clin. Med. 2022, 11(24), 7532; https://doi.org/10.3390/jcm11247532
Submission received: 14 November 2022 / Revised: 8 December 2022 / Accepted: 14 December 2022 / Published: 19 December 2022
(This article belongs to the Special Issue Wound Healing and Plastic Surgery: Challenges and Innovations)

Round 1

Reviewer 1 Report

For this review article, the authors have selected a topic with high potential. Manuscript is very well written covering almost all aspect. There are few gaps which have to be addressed.  

1.      Update the Reference for Cost of Wound Management 

2.       Clarify if  analysis has focused PRP Treatment for all types of Chronic Wound Management or just 2 or 3 types of Wounds which authors have listed in Table 1??  If authors are focusing only specific wounds then it is suggested to modify the title.  

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report


1. The main question addressed by the research is to find out the therapeutic effect of PRP on chronic wound 
2. There is no showing good novelty compared with other similar publications. 
3. The  methodology is well structured, but there is no part to evaluate risk of bias. 
4. The conclusions are consistent with the evidence and arguments presented
5. The references are appropriate. 
6. There is no part to evaluate risk of bias on the figures.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 3 Report

This manuscript is based on systematic review and meta-analysis of RCT on patients with chronic wounds treated with platelet-rich plasma. The materials, methods and results are well described and presented. The paper addresses an important and interesting aspect of current issue in wound healing. The parameters discussed (complete wound, closure, reduction of wound area, healing time, infection rate and pain) are the standard parameters assessed in wound healing research. However, as this review and the trials are based on clinical aspects without taking in account of cost and other non-clinical factors, it is more appropriate to use the term “clinical efficacy” rather than ‘efficacy’ to give better context to the review.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 2 Report

  • It is not necessary to revise manuscript.
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