The Relationship between Sarcopenia and Injury Events: A Systematic Review and Meta-Analysis of 98,754 Older Adults
Abstract
:1. Introduction
Aims
2. Methods
2.1. Sarcopenia Assessment
2.2. Data Sources and Search Strategy
2.3. Inclusion and Exclusion Criteria
2.4. Data Extraction
2.5. Quality Assessment
2.6. Statistical Analysis
2.7. IRB Approval Number
3. Results
3.1. Study Sample
3.2. Quality Assessment
3.3. Association between Sarcopenia and Injury Events
First Author | Selection | Comparability | Outcome | ||||||
---|---|---|---|---|---|---|---|---|---|
Representativeness of the Exposed Cohort | Selection of the Non-Exposed Cohort | Ascertainment of Exposure | Demonstration that Outcome of Interest was not Present at the Start of the Study | Comparability of Cohorts on the Basis of the Design or Analysis | Assessment of Outcome | Was Follow-Up Long Enough for Outcomes to Occur? | Adequacy of Follow-up of Cohorts | Overall Quality Score (Maximum = 9) | |
da Silva Alexandre et al. [10] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Aliberti et al. [11] | ★ | - | ★ | ★ | ★★ | ★ | ★ | ★ | 8 |
Arango-Lopera et al. [41] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Benjumea et al. [30] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Bianchi et al. [40] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Brown et al. [42] | ★ | - | ★ | ★ | ★★ | ★ | ★ | ★ | 8 |
Buckinx et al. [31] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Cawthon et al. [38] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Gariballa et al. (2013) | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Cawthon et al. [46] | ★ | - | ★ | ★ | ★★ | ★ | ★ | ★ | 8 |
Chalhoub et al. [37] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Harris et al. [21] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Henwood et al. [22] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Landi et al. [23] | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 8 | |
Lera et al. [43] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Lim et al. [32] | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 8 | |
Landi et al. [14] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Matsumoto et al. [33] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Peng et al. [44] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Pérez-Zepeda et al. [25] | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 8 | |
Psutka et al. [45] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Scott et al. [36] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Sjoblom et al. [16] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Tanimoto et al. [18] | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 8 | |
Tao et al. [19] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Vetrano et al. [20] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Villasenor et al. [5] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Woo et al. [6] | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 8 | |
Yang et al. [7] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Yu et al. [3] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
Ziolkowski et al. [2] | ★ | ★ | ★ | ★ | ★★ | ★ | ★ | ★ | 9 |
4. Discussion
4.1. Conclusions
4.2. Clinical Implications
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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No. | First Author | Population | Sarcopenia Criteria | Sample Size | Sex | Age | Length of Follow Up | HR (95% CI) | Variable Adjusted |
---|---|---|---|---|---|---|---|---|---|
Fall | |||||||||
1 | Benjumea et al. [30] | Clinic | EWGSOP | 534 | F | 75 | 12 years | 1.06 (0.98–1.14) | None |
2 | Buckinx et al. [31] | Nursing home | EWGSOP | 662 | F/M | ≥85 | 1-year | 1.70 (1.10–2.92) | None |
3 | Henwood et al. [22] | Nursing home | EWGSOP | 58 | F/M | 75–95 | 18 months | 0.74 (0.34–1.63) | None |
4 | Lim et al. [32] | Hospitalized patients | AWGS | 147 | F | 65 | 2.5 years | 2.354 (1.177–4.709) | None |
5 | Matsumoto et al. [33] | Hospitalized patients | EWGSOP | 162 | F/M | 60 | 2 years | 7.68 (1.41–41.77) | Adjusted for age, sex, body mass index, previous falls, locomotive syndrome and visual analog scale. |
6 | Mori and Tokuda [34] | Community-dwelling | AWGS | 331 | F | ≥70 | 2-year | 3.03 (1.01–9.09) | None |
7 | Schaap et al. [35] | Community-dwelling | EWGSOP | 496 | F/M | 75 | 3 years | 1.29 (0.89–1.87) | Adjusting for age, sex, and total body fat |
8 | Scott et al. [36] | Community-dwelling | EWGSOP | 101/1575 | M | ≥70 | 2 years | 2.15 (1.58–2.94) | Adjusted for age, income, living alone, number of comorbidities, smoking status, psychotropic and corticosteroid use, history of fracture, physical activity and 25(OH)D. |
9 | Sjoblom et al. [16] | Community-dwelling | EWGSOP | 590 | F | 65–72 | 1-year | 3.3 (1.6–7.0) | Adjusted for: age, body mass index (BMI), physical activity and hormone therapy (HT). |
10 | Woo et al. [6] | Community-dwelling | AWGS | 2848 | F/M | 65 | 1-year | 1.59 (1.02–2.49) | None |
Fracture | |||||||||
1 | Chalhoub et al. [37] | Community-dwelling | EWGSOP | 5544 | F/M | 65 | 2 years | 1.19 (0.65–2.17) | Adjusted Age |
2 | Cawthon et al. [38] | Community-dwelling | EWGSOP | 1516 | F/M | 70–80 | 3 years | 1.68 (0.74–3.81) | None |
3 | Chen et al. [39] | Hospitalized patients | EWGSOP | 990 | F/M | 60 | 1-year | 2.03 (1.29–3.19) | None |
4 | Harris et al. [21] | clinical centers | EWGSOP | 10,937 | F | 63 | 3 years | 0.85 (0.64–1.12) | Adjusted for age, clinic, and race. |
5 | Schaap et al. [35] | Community-dwelling | EWGSOP | 496 | F/M | 75 | 10 years | 0.94 (0.54–1.64) | adjusting for age, sex, and total body fat |
6 | Scott et al. [36] | Community-dwelling | EWGSOP | 106/1575 | M | ≥70 | 2 years | 1.06 (0.51–2.18) | Adjusted for age, income, living alone, number of comorbidities, smoking status, psychotropic and corticosteroid use, history of fracture, |
7 | Sjoblom et al. [16] | Community-dwelling | EWGSOP | 590 | F | 65–72 | 1-year | 2.60 (1.84–3.68) | Adjusted for: age, body mass index (BMI), physical activity and hormone therapy(HT) |
8 | Yu et al. [3] | Community-dwelling | AWGS | 4000 | F/M | 65 | 1.5 years | 4.74 (2.71–8.28) | None |
Hospitalization | |||||||||
1 | Aliberti et al. [11] | Hospitalized patients | EWGSOP | 203/665 | F | 80 | 1-year | 1.53 (1.16–2.04) | adjusted for age, sex, race, income |
2 | Bianchi et al. [40] | Community-dwelling | EWGSOP | 55/538 | F | 65–94 | 2 years | 1.57 (1.03–2.41) | |
3 | Cawthon et al. [38] | Community-dwelling | EWGSOP | 421/1516 | F/M | 70–80 | 3 years | 1.27 (0.85–1.90) | adjusted -Age |
4 | Gariballa (2013) | Hospitalized patients | EWGSOP | 432 | F | ≥65 | 180 days | 0.53 (0.32–0.87) | |
5 | Henwood [22] | Nursing home | EWGSOP | 58 | F/M | 75–95 | 18 months | 1.25 (0.73–2.14) | |
6 | Pérez-Zepeda et al. [25] | Hospitalized patients | EWGSOP | 172 | F/M | ≥70 | 1-year | 0.92 (0.62–1.37) | |
7 | Yang et al. [7] | Hospitalized patients | AWGS | 313 | M | 60 | 3 years | 1.82 (1.28–2.59) | |
Functional disability | |||||||||
1 | da Silva Alexandre et al. [10] | Community-dwelling | EWGSOP | 328/478 | F/M | 60 | 4-year | 5.26 (0.84 –2.84) | None |
2 | Benjumea et al. [30] | Clinic | EWGSOP | 144/534 | F | 75 | 12 years | 2.03 (1.18–3.50) | None |
3 | Bianchi et al. [40] | Community-dwelling | EWGSOP | 36/538 | F | 65–94 | 2 years | 4.78 (1.84–12.7) | adjusting for Age and Sex |
4 | Tanimoto et al. [18]) | Community-dwelling | EWGSOP | 743 | F/M | 65 | 2-year | 10.4 (1.8–59.8) | adjusted for age and body mass index |
5 | Woo et al. [6] | Community-dwelling | AWGS | 4000 | F/M | 65 | 4-year | 2.04 (1.32–3.17) | adjusted for age, education, COPD, diabetes mellitus, hypertension, heart disease, current smoker, MMSE, and depression |
Mortality | |||||||||
1 | Aliberti et al. [11] | In-hospital patients | EWGSOP | 203/665 | F | 80 | 1-year | 2.46 (1.63–3.72) | adjusted for age, sex, race, income |
2 | Androga et al. [12] | In-hospital patients | EWGSOP | 1082 | M | 65 | 5 years | 1.32 (1.06–1.66) | None |
3 | Arango-Lopera et al. [41] | Community-dwelling | EWGSOP | 345 | F/M | 78 | 5 years | 2.39 (1.05–5.43) | None |
4 | Bianchi et al. [40] | Community-dwelling | EWGSOP | 55/538 | F | 65–94 | 2 years | 4.28 (2.42–7.59) | None |
5 | Brown et al. [42] | Community dwelling | EWGSOP | 4425 | F/M | ≥60 | 6 years | 1.29 (1.13–1.47) | None |
6 | Buckinx et al. [31] | Nursing home | EWGSOP | 662 | F/M | ≥85 | 1-year | 1.70 (1.10–2.92) | None |
7 | Gariballa (2013) | In-hospital patients | EWGSOP | 258 | F/M | ≥65 | 180 days | 0.45 (0.21–0.97) | None |
8 | Henwood [22] | Nursinghome | EWGSOP | 58 | F/M | 75–95 | 18 months | 0.81 (0.33–1.98) | None |
9 | Landi et al. [14] | Community dwelling | EWGSOP | 197 | F/M | 80–85 | 300 days | 2.95 (1.44–6.04) | None |
10 | Landi et al. [23] | Nursing home | EWGSOP | 146 | F/M | >70 | 300 days | 3.87 (1.57–9.54) | None |
11 | Lera et al. [43] | community-dwelling | EWGSOP | 2311 | F/M | ≥60 | 5-year | 1.39 (1.07–1.82) | adjusting for age, sex, nutritional status, and number of chronic diseases, |
12 | Pereira et al. [24] | In-hospital patients | EWGSOP | 287 | M | ≥70 | 40 months. | 3.02 (1.30–7.05) | None |
13 | Peng et al. [44] | In-hospital patients | EWGSOP | 1953 | F/M | 65 | 2 years | 1.63 (1.28–2.07) | None |
14 | Psutka et al. [45] | In-hospital patients | EWGSOP | 205 | F/M | 72 | 2 years | 2.14 (1.24–3.71) | None |
15 | Tandon et al. [17] | Community-dwelling | EWGSOP | 258 | F/M | ≥18 | 2 years | 2.36 (1.23–4.53) | None |
16 | Tao et al. [19] | In-hospital patients | EWGSOP | 427 | M | 80 | 32 months | 2.36 (1.31–4.24) | None |
17 | Vetrano et al. [20] | In-hospital patients | EWGSOP | 770 | F | 82 | 1 year | adjusting for Age- and Gender | |
18 | Villasenor et al. [5] | In-hospital patients | EWGSOP | 75/471 | F | ≥50 | 270 days | 1.65 (0.78–3.52) | adjusted-Age |
19 | Yang et al. [7] | In-hospital patients | AWGS | 313 | M | 60 | 3 years | 2.67 (1.55–4.60) | None |
20 | Ziolkowski et al. [2] | Community-dwelling | EWGSOP | 534 | F | ≥60 | 2 years | 2.20 (1.69–2.86) | adjustment for age, sex, race/ethnicity, physical activity, smoking status, diabetes, cancer, liver disease, ardiovascular disease, education, and income |
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Su, Y.-C.; Chang, S.-F.; Tsai, H.-C. The Relationship between Sarcopenia and Injury Events: A Systematic Review and Meta-Analysis of 98,754 Older Adults. J. Clin. Med. 2022, 11, 6474. https://doi.org/10.3390/jcm11216474
Su Y-C, Chang S-F, Tsai H-C. The Relationship between Sarcopenia and Injury Events: A Systematic Review and Meta-Analysis of 98,754 Older Adults. Journal of Clinical Medicine. 2022; 11(21):6474. https://doi.org/10.3390/jcm11216474
Chicago/Turabian StyleSu, Yu-Chen, Shu-Fang Chang, and Hsiao-Chi Tsai. 2022. "The Relationship between Sarcopenia and Injury Events: A Systematic Review and Meta-Analysis of 98,754 Older Adults" Journal of Clinical Medicine 11, no. 21: 6474. https://doi.org/10.3390/jcm11216474