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Volume 11
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10.3390/jcm11020450
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Article

Predictive Role of the D-Dimer Level in Acute Kidney Injury in Living Donor Liver Transplantation: A Retrospective Observational Cohort Study

by
Jaesik Park
1,
Sung Un Kim
2,
Ho Joong Choi
3,
Sang Hyun Hong
1 and
Min Suk Chae
1,*
1
Department of Anesthesiology and Pain Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
2
Department of Anesthesiology and Pain Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon 16247, Korea
3
Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2022, 11(2), 450; https://doi.org/10.3390/jcm11020450
Submission received: 10 November 2021 / Revised: 11 January 2022 / Accepted: 13 January 2022 / Published: 16 January 2022
(This article belongs to the Special Issue Recent Advances in Liver Transplantation and Adjacent Therapies)
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Abstract

This study aimed to determine the association between serum D-dimer levels and the risk of acute kidney injury (AKI) in patients undergoing living donor liver transplantation (LDLT). Clinical data of 675 patients undergoing LDLT were retrospectively analyzed. The exclusion criteria included a history of kidney dysfunction, emergency cases, and missing data. The final study population of 617 patients was divided into the normal and high D-dimer groups (cutoff: 0.5 mg/L). After LDLT, 145 patients (23.5%) developed AKI. A high D-dimer level (>0.5 mg/L) was an independent predictor of postoperative development of AKI in the multivariate analysis when combined with diabetes mellitus [DM], platelet count, and hourly urine output. AKI was significantly higher in the high D-dimer group than in the normal D-dimer group (odds ratio [OR], 2.792; 95% confidence interval [CI], 1.227–6.353). Patients with a high D-dimer exhibited a higher incidence of early allograft dysfunction, longer intensive care unit stay, and a higher mortality rate. These results could improve the risk stratification of postoperative AKI development by encouraging the determination of preoperative D-dimer levels in patients undergoing LDLT.
Keywords: D-dimer; acute kidney injury; living donor liver transplantation D-dimer; acute kidney injury; living donor liver transplantation

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MDPI and ACS Style

Park, J.; Kim, S.U.; Choi, H.J.; Hong, S.H.; Chae, M.S. Predictive Role of the D-Dimer Level in Acute Kidney Injury in Living Donor Liver Transplantation: A Retrospective Observational Cohort Study. J. Clin. Med. 2022, 11, 450. https://doi.org/10.3390/jcm11020450

AMA Style

Park J, Kim SU, Choi HJ, Hong SH, Chae MS. Predictive Role of the D-Dimer Level in Acute Kidney Injury in Living Donor Liver Transplantation: A Retrospective Observational Cohort Study. Journal of Clinical Medicine. 2022; 11(2):450. https://doi.org/10.3390/jcm11020450

Chicago/Turabian Style

Park, Jaesik, Sung Un Kim, Ho Joong Choi, Sang Hyun Hong, and Min Suk Chae. 2022. "Predictive Role of the D-Dimer Level in Acute Kidney Injury in Living Donor Liver Transplantation: A Retrospective Observational Cohort Study" Journal of Clinical Medicine 11, no. 2: 450. https://doi.org/10.3390/jcm11020450

APA Style

Park, J., Kim, S. U., Choi, H. J., Hong, S. H., & Chae, M. S. (2022). Predictive Role of the D-Dimer Level in Acute Kidney Injury in Living Donor Liver Transplantation: A Retrospective Observational Cohort Study. Journal of Clinical Medicine, 11(2), 450. https://doi.org/10.3390/jcm11020450

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