Primary Epstein–Barr Virus-Positive Mucocutaneous Ulcer of Esophagus: A Rare Case Report
Abstract
:1. Introduction
2. Case Presentation
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
EBV | Epstein–Barr virus |
EBVMCU | Epstein–Barr virus-positive mucocutaneous ulcer |
EBV-LPDs | Epstein–Barr virus-associated lymphoproliferative diseases |
IHC | Immunohistochemistry |
PET-CT | Positron emission tomography–computer tomography |
EBER | In situ hybridization with Epstein–Barr virus-encoded small RNA |
ISH | In situ hybridization |
PD-L1 | Programmed cell death-ligand 1 |
LDH | Lactate dehydrogenase |
HIV | Human immunodeficiency virus |
CMV | Cytomegalovirus |
HSV | Herpes simplex virus |
HHV-8 | Human herpesvirus 8 |
PCR | Polymerase Chain Reaction |
EBV-B-LPDs | Epstein–Barr virus B-cell lymphoproliferative diseases |
EBV+ DLBCL | EBV positive diffuse large B-cell lymphoma |
NOS | Not otherwise specified |
DLBCL-CI | DLBCL-associated chronic inflammation |
LyG | Lymphomatoid granulomatosis |
GIT | Gastrointestinal tract |
RS | Reed–Sternberg |
TCR | T cell receptor |
VZV | Varicella-zoster virus |
HRS | Hodgkin’s lymphoma Reed–Sternberg |
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Age/Sex | Main Symptoms | Endoscopic Results | Diagnosis | Treatment |
---|---|---|---|---|
23/M [27] | Fever Diaphoresis Lethargy Weight loss Odynophagia Hematemesis | Multiple ulcerations | Positive Monospot and Paul Bunnell tests | Symptomatic |
27/F [28] | Dysphagia Odynophagia | Multiple well-circumscribed Ulcerations differing depths | PCR on biopsy materials | Aciclovir for 5 days |
48/M [29] | Fever Nausea Dysphagia | Denuded extensive ulcerations | PCR on biopsy samples | Aciclovir for 14 days |
18/M [30] | Fever Muscle pain heartburn Epigastric pain dysphagia Odynophagia | Multiple, centimeter long, linear and circular ulcerations of various depth | EBV serology Positive EBV-specific ISH PCR analysis of biopsy specimens | Symptomatic |
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Sun, C.; Wang, Q.; Dong, Y.; Nong, L.; Cai, Y.; Wang, L.; Sun, Y.; Wang, W.; Liu, X. Primary Epstein–Barr Virus-Positive Mucocutaneous Ulcer of Esophagus: A Rare Case Report. J. Clin. Med. 2022, 11, 4915. https://doi.org/10.3390/jcm11164915
Sun C, Wang Q, Dong Y, Nong L, Cai Y, Wang L, Sun Y, Wang W, Liu X. Primary Epstein–Barr Virus-Positive Mucocutaneous Ulcer of Esophagus: A Rare Case Report. Journal of Clinical Medicine. 2022; 11(16):4915. https://doi.org/10.3390/jcm11164915
Chicago/Turabian StyleSun, Chunping, Qingya Wang, Yujun Dong, Lin Nong, Yunlong Cai, Lihong Wang, Yuhua Sun, Wensheng Wang, and Xinmin Liu. 2022. "Primary Epstein–Barr Virus-Positive Mucocutaneous Ulcer of Esophagus: A Rare Case Report" Journal of Clinical Medicine 11, no. 16: 4915. https://doi.org/10.3390/jcm11164915