Potential Therapeutic Applications of Natural Compounds in Diabetes-Associated Periodontitis

Ng, Min Yee; Lin, Taichen; Chao, Shih-Chi; Chu, Pei-Ming; Yu, Cheng-Chia

doi:10.3390/jcm11133614

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Potential Therapeutic Applications of Natural Compounds in Diabetes-Associated Periodontitis

by

Min Yee Ng

^1,†

,

Taichen Lin

^1,2,†

,

Shih-Chi Chao

^3,4

,

Pei-Ming Chu

⁵ and

Cheng-Chia Yu

^1,2,3,*

¹

School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan

²

Department of Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan

³

Institute of Oral Sciences, Chung Shan Medical University, Taichung 40201, Taiwan

⁴

Department of Medical Research and Education, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yi-lan, Luodong 265501, Taiwan

⁵

Department of Anatomy, School of Medicine, China Medical University, Taichung 404333, Taiwan

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

J. Clin. Med. 2022, 11(13), 3614; https://doi.org/10.3390/jcm11133614

Submission received: 3 May 2022 / Revised: 10 June 2022 / Accepted: 15 June 2022 / Published: 22 June 2022

(This article belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

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Abstract

Diabetes mellitus (DM) is a major worldwide health burden. DM is a metabolic disease characterized by chronic hyperglycemia, and if left untreated, can lead to various complications. Individuals with uncontrolled DM are more susceptible to periodontitis due to both a hyper-inflammatory host response and an impaired immune response. Periodontitis, on the other hand, may exacerbate DM by increasing both local and systemic inflammatory components of DM-related complications. The current standard for periodontal treatment in diabetes-associated periodontitis (DP) focuses mostly on reducing bacterial load and less on controlling the excessive host response, and hence, may not be able to resolve DP completely. Over the past decade, natural compounds have emerged as an adjunct approach for modulating the host immune response with the hope of curing DP. The anti-oxidant, anti-inflammatory, and anti-diabetic characteristics of natural substances are well-known, and they can be found in regularly consumed foods and drinks, as well as plants. The pathophysiology of DP and the treatment benefits of various bioactive extracts for DP will be covered in this review.

Keywords: diabetes-associated periodontitis; natural compounds

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MDPI and ACS Style

Ng, M.Y.; Lin, T.; Chao, S.-C.; Chu, P.-M.; Yu, C.-C. Potential Therapeutic Applications of Natural Compounds in Diabetes-Associated Periodontitis. J. Clin. Med. 2022, 11, 3614. https://doi.org/10.3390/jcm11133614

AMA Style

Ng MY, Lin T, Chao S-C, Chu P-M, Yu C-C. Potential Therapeutic Applications of Natural Compounds in Diabetes-Associated Periodontitis. Journal of Clinical Medicine. 2022; 11(13):3614. https://doi.org/10.3390/jcm11133614

Chicago/Turabian Style

Ng, Min Yee, Taichen Lin, Shih-Chi Chao, Pei-Ming Chu, and Cheng-Chia Yu. 2022. "Potential Therapeutic Applications of Natural Compounds in Diabetes-Associated Periodontitis" Journal of Clinical Medicine 11, no. 13: 3614. https://doi.org/10.3390/jcm11133614

APA Style

Ng, M. Y., Lin, T., Chao, S.-C., Chu, P.-M., & Yu, C.-C. (2022). Potential Therapeutic Applications of Natural Compounds in Diabetes-Associated Periodontitis. Journal of Clinical Medicine, 11(13), 3614. https://doi.org/10.3390/jcm11133614

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Potential Therapeutic Applications of Natural Compounds in Diabetes-Associated Periodontitis

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