Preoperative Serum Alkaline Phosphatase and Neurological Outcome of Cerebrovascular Surgery
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Lower Group (n = 70) | Middle Group (n = 70) | Higher Group (n = 71) | p Value | |
---|---|---|---|---|
Demographic data | ||||
Age (year) | 61.8 ± 11.3 | 64.2 ± 11.4 | 64.6 ± 11.7 | 0.285 |
Body-mass index | 24.0 ± 3.4 | 24.2 ± 2.6 | 24.4 ± 3.6 | 0.783 |
Male | 47 (72.3%) | 46 (69.7%) | 58 (72.5%) | 0.073 |
Past history | ||||
Smoking | 29 (44.6%) | 23 (34.8%) | 36 (45.0%) | 0.371 |
Diabetes mellitus | 25 (38.5%) | 28 (42.4%) | 22 (27.5%) | 0.162 |
Hypertension | 44 (67.7%) | 45 (68.2%) | 50 (62.5%) | 0.787 |
Stroke | 25 (38.5%) | 25 (37.9%) | 35 (43.8%) | 0.723 |
Myocardial infarction | 7 (10.8%) | 6 (9.1%) | 10 (12.5%) | 0.805 |
Laboratory variables | ||||
CRP (mg/L) | 0.1 ± 0.2 | 0.3 ± 1.3 | 0.5 ± 1.9 | 0.114 |
Hemoglobin (g/dL) | 13.5 ± 1.5 | 14.4 ± 7.4 | 13.6 ± 1.6 | 0.438 |
Cholesterol (mg/dL) | 150.3 ± 44.5 | 158.9 ± 44.9 | 158.3 ± 40.1 | 0.427 |
Calcium (mg/dL) | 8.7 ± 0.8 | 8.9 ± 0.5 | 8.8 ± 0.7 | 0.475 |
Phosphorus (mg/dL) | 44.7 ± 17.3 | 60.6 ± 23.9 | 89.2 ± 45.0 | <0.001 |
Creatinine | 0.9 ± 0.3 | 1.0 ± 0.3 | 0.9 ± 0.3 | 0.273 |
Albumin (g/dL) | 4.0 ± 0.6 | 4.2 ± 0.5 | 4.1 ± 0.4 | 0.238 |
Bilirubin (mg/dL) | 0.7 ± 0.2 | 0.7 ± 0.3 | 0.6 ± 0.3 | 0.651 |
AST (IU/dL) | 24.8 ± 19.1 | 25.5 ± 23.6 | 28.1 ± 14.7 | 0.583 |
ALT (IU/dL) | 26.7 ± 22.8 | 30.8 ± 33.0 | 35.0 ± 25.0 | 0.193 |
ALP (IU/dL) | 49.4 ± 10.6 | 70.2 ± 4.8 | 102.7 ± 30.1 | <0.001 |
Lower Group (n = 70) | Middle Group (n = 70) | Higher Group (n = 71) | p Value | |
---|---|---|---|---|
Acute infarction | 4 (5.7%) | 2 (2.9%) | 12 (16.9%) | 0.007 |
No Infarction (n = 193) | Infarction (n = 18) | p Value | |
---|---|---|---|
Demographic data | |||
Age (year) | 63.7 ± 11.4 | 61.8 ± 12.5 | 0.497 |
Body-mass index | 24.2 ± 3.3 | 24.1 ± 2.3 | 0.836 |
Male | 136 (70%) | 15(83%) | 0.290 |
Past history | |||
Smoking | 80 (41%) | 8 (44%) | 0.799 |
Diabetes mellitus | 71 (37%) | 4 (22%) | 0.307 |
Hypertension | 129 (67%) | 10 (56%) | 0.503 |
Stroke | 48 (25%) | 3 (17%) | 0.575 |
Myocardial infarction | 21 (11%) | 2 (11%) | 1.000 |
Laboratory variables | |||
CRP (mg/L) | 0.3 ± 1.4 | 0.3 ± 0.7 | 0.960 |
Hemoglobin (g/dL) | 13.9 ± 4.6 | 13.5 ± 2.0 | 0.689 |
Cholesterol (mg/dL) | 156.7 ± 43.1 | 147.2 ± 44.4 | 0.374 |
Calcium (mg/dL) | 8.8 ± 0.7 | 8.8 ± 4.8 | 0.969 |
Phosphorus (mg/dL) | 64.1 ± 34.2 | 73.8 ± 53.3 | 0.280 |
Creatinine | 0.9 ± 0.3 | 0.9 ± 0.2 | 0.775 |
Albumin (g/dL) | 4.1 ± 0.5 | 4.2 ± 0.4 | 0.615 |
Bilirubin (mg/dL) | 0.7 ± 0.3 | 0.7 ± 0.3 | 0.757 |
AST (IU/dL) | 26.4 ± 20.1 | 23.1 ± 9.5 | 0.488 |
ALT (IU/dL) | 30.8 ± 27.5 | 31.7 ± 27.3 | 0.897 |
AST/ALT ratio | 1.0 ± 0.5 | 1.0 ± 0.7 | 0.972 |
ALP (IU/dL) | 72.5 ± 27.9 | 92.5 ± 33.3 | 0.005 |
OR (95% CI) | p Value | |
---|---|---|
ALP third tertile | 3.356 (1.026–10.974) | 0.045 |
Cholesterol | 0.995 (0.983–1.006) | 0.372 |
AST/ALT ratio | 0.983 (0.377–2.560) | 0.971 |
ALP third tertile | 3.356 (1.026–10.974) | 0.045 |
Event Number | Hazard Ratio | 95% CI of Hazard Ratio | p Value | |
---|---|---|---|---|
Acute infarction | 18 | 1.013 | 1.004–1.022 | 0.007 |
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Park, S.; Choi, E.-S.; Jung, H.-W.; Lee, J.-Y.; Park, J.-W.; Bang, J.-S.; Jeon, Y.-T. Preoperative Serum Alkaline Phosphatase and Neurological Outcome of Cerebrovascular Surgery. J. Clin. Med. 2022, 11, 2981. https://doi.org/10.3390/jcm11112981
Park S, Choi E-S, Jung H-W, Lee J-Y, Park J-W, Bang J-S, Jeon Y-T. Preoperative Serum Alkaline Phosphatase and Neurological Outcome of Cerebrovascular Surgery. Journal of Clinical Medicine. 2022; 11(11):2981. https://doi.org/10.3390/jcm11112981
Chicago/Turabian StylePark, Seongjoo, Eun-Su Choi, Hee-Won Jung, Ji-Youn Lee, Jin-Woo Park, Jae-Seung Bang, and Yeong-Tae Jeon. 2022. "Preoperative Serum Alkaline Phosphatase and Neurological Outcome of Cerebrovascular Surgery" Journal of Clinical Medicine 11, no. 11: 2981. https://doi.org/10.3390/jcm11112981