Risk Factors for Mortality in COVID-19 Hospitalized Patients in Piedmont, Italy: Results from the Multicenter, Regional, CORACLE Registry

Background: CORACLE is a retrospective and prospective, regional multicenter registry, developed to evaluate risk factors for mortality in a cohort of patients admitted with SARS-CoV-2 infection within non-intensive wards. Methods: The primary objective was to estimate the role of several prognostic factors on hospital mortality in terms of adjusted Odds Ratios (aOR) with multivariable logistic regression models. Results: A total of 1538 patients were enrolled; 42% were female, and 58% were >70 years old. Deceased patients were 422 (27%), with a median age of 83 years (IQR (Inter Quartile Range) 76–87). Older age at admission (aOR 1.07 per year, 95%CI 1.06–1.09), diabetes (1.41, 1.02–1.94), cardiovascular disease (1.79, 1.31–2.44), immunosuppression (1.65, 1.04–2.62), estimated glomerular filtration rate (eGFR) <30 mL/min/1.73 m² (3.53, 2.26–5.51), higher C-reactive protein values and a decreased PaO₂/FiO₂ ratio at admission were associated with a higher risk of hospital mortality. Amongst patients still alive on day 7, only hydroxychloroquine (HCQ) treatment was associated with reduced mortality (0.57, 0.36–0.90). Conclusions: Several risk factors were associated with mortality in SARS-CoV-2 positive patients. Although HCQ seems to be the only factor significantly associated with reduced mortality, this result is in contrast with evidence from randomized studies. These results should be interpreted in light of the study limitations. View Full-Text

Keywords: COVID-19; pneumonia; mortality; hydroxichloroquine; SARS-CoV-2

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De Rosa, F.G.; Palazzo, A.; Rosso, T.; Shbaklo, N.; Mussa, M.; Boglione, L.; Borgogno, E.; Rossati, A.; Mornese Pinna, S.; Scabini, S.; Chichino, G.; Borrè, S.; Del Bono, V.; Garavelli, P.L.; Barillà, D.; Cattel, F.; Di Perri, G.; Ciccone, G.; Lupia, T.; Corcione, S. Risk Factors for Mortality in COVID-19 Hospitalized Patients in Piedmont, Italy: Results from the Multicenter, Regional, CORACLE Registry. J. Clin. Med. 2021, 10, 1951. https://doi.org/10.3390/jcm10091951

AMA Style

De Rosa FG, Palazzo A, Rosso T, Shbaklo N, Mussa M, Boglione L, Borgogno E, Rossati A, Mornese Pinna S, Scabini S, Chichino G, Borrè S, Del Bono V, Garavelli PL, Barillà D, Cattel F, Di Perri G, Ciccone G, Lupia T, Corcione S. Risk Factors for Mortality in COVID-19 Hospitalized Patients in Piedmont, Italy: Results from the Multicenter, Regional, CORACLE Registry. Journal of Clinical Medicine. 2021; 10(9):1951. https://doi.org/10.3390/jcm10091951

Chicago/Turabian Style

De Rosa, Francesco G., Annagloria Palazzo, Tiziana Rosso, Nour Shbaklo, Marco Mussa, Lucio Boglione, Enrica Borgogno, Antonella Rossati, Simone Mornese Pinna, Silvia Scabini, Guido Chichino, Silvio Borrè, Valerio Del Bono, Pietro L. Garavelli, Diego Barillà, Francesco Cattel, Giovanni Di Perri, Giovannino Ciccone, Tommaso Lupia, and Silvia Corcione. 2021. "Risk Factors for Mortality in COVID-19 Hospitalized Patients in Piedmont, Italy: Results from the Multicenter, Regional, CORACLE Registry" Journal of Clinical Medicine 10, no. 9: 1951. https://doi.org/10.3390/jcm10091951

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Risk Factors for Mortality in COVID-19 Hospitalized Patients in Piedmont, Italy: Results from the Multicenter, Regional, CORACLE Registry

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