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Article

Risk Factors for Mortality in COVID-19 Hospitalized Patients in Piedmont, Italy: Results from the Multicenter, Regional, CORACLE Registry

1
Department of Medical Sciences, University of Turin, 10126 Turin, Italy
2
Infectious Diseases Unit, Cardinal Massaia Hospital, 14100 Asti, Italy
3
Unit of Clinical Epidemiology, CPO, AOU “Città della Salute e della Scienza”, 10126 Turin, Italy
4
Infectious Diseases Unit, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy
5
Department of Translational Medicine, University of Eastern Piedmont, 13100 Novara, Italy
6
Infectious Diseases Unit, Azienda Ospedaliera S. Croce e Carle, 12100 Cuneo, Italy
7
Infectious Diseases Department, University Hospital “Maggiore della Carità”, 28100 Novara, Italy
8
Unit of Infectious Diseases, Saint Andrea Hospital, 13100 Vercelli, Italy
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Hospital Pharmacy, Città della Salute e della Scienza, 10126 Turin, Italy
10
Department of Infectious Diseases, Tufts University School of Medicine, Boston, MA 02109, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Emanuele Nicastri and Simone Lanini
J. Clin. Med. 2021, 10(9), 1951; https://doi.org/10.3390/jcm10091951
Received: 19 February 2021 / Revised: 22 April 2021 / Accepted: 26 April 2021 / Published: 1 May 2021
(This article belongs to the Collection Clinical Trends and Therapies of the COVID-19 Pandemic)
Background: CORACLE is a retrospective and prospective, regional multicenter registry, developed to evaluate risk factors for mortality in a cohort of patients admitted with SARS-CoV-2 infection within non-intensive wards. Methods: The primary objective was to estimate the role of several prognostic factors on hospital mortality in terms of adjusted Odds Ratios (aOR) with multivariable logistic regression models. Results: A total of 1538 patients were enrolled; 42% were female, and 58% were >70 years old. Deceased patients were 422 (27%), with a median age of 83 years (IQR (Inter Quartile Range) 76–87). Older age at admission (aOR 1.07 per year, 95%CI 1.06–1.09), diabetes (1.41, 1.02–1.94), cardiovascular disease (1.79, 1.31–2.44), immunosuppression (1.65, 1.04–2.62), estimated glomerular filtration rate (eGFR) <30 mL/min/1.73 m2 (3.53, 2.26–5.51), higher C-reactive protein values and a decreased PaO2/FiO2 ratio at admission were associated with a higher risk of hospital mortality. Amongst patients still alive on day 7, only hydroxychloroquine (HCQ) treatment was associated with reduced mortality (0.57, 0.36–0.90). Conclusions: Several risk factors were associated with mortality in SARS-CoV-2 positive patients. Although HCQ seems to be the only factor significantly associated with reduced mortality, this result is in contrast with evidence from randomized studies. These results should be interpreted in light of the study limitations. View Full-Text
Keywords: COVID-19; pneumonia; mortality; hydroxichloroquine; SARS-CoV-2 COVID-19; pneumonia; mortality; hydroxichloroquine; SARS-CoV-2
MDPI and ACS Style

De Rosa, F.G.; Palazzo, A.; Rosso, T.; Shbaklo, N.; Mussa, M.; Boglione, L.; Borgogno, E.; Rossati, A.; Mornese Pinna, S.; Scabini, S.; Chichino, G.; Borrè, S.; Del Bono, V.; Garavelli, P.L.; Barillà, D.; Cattel, F.; Di Perri, G.; Ciccone, G.; Lupia, T.; Corcione, S. Risk Factors for Mortality in COVID-19 Hospitalized Patients in Piedmont, Italy: Results from the Multicenter, Regional, CORACLE Registry. J. Clin. Med. 2021, 10, 1951. https://doi.org/10.3390/jcm10091951

AMA Style

De Rosa FG, Palazzo A, Rosso T, Shbaklo N, Mussa M, Boglione L, Borgogno E, Rossati A, Mornese Pinna S, Scabini S, Chichino G, Borrè S, Del Bono V, Garavelli PL, Barillà D, Cattel F, Di Perri G, Ciccone G, Lupia T, Corcione S. Risk Factors for Mortality in COVID-19 Hospitalized Patients in Piedmont, Italy: Results from the Multicenter, Regional, CORACLE Registry. Journal of Clinical Medicine. 2021; 10(9):1951. https://doi.org/10.3390/jcm10091951

Chicago/Turabian Style

De Rosa, Francesco Giuseppe, Annagloria Palazzo, Tiziana Rosso, Nour Shbaklo, Marco Mussa, Lucio Boglione, Enrica Borgogno, Antonella Rossati, Simone Mornese Pinna, Silvia Scabini, Guido Chichino, Silvio Borrè, Valerio Del Bono, Pietro Luigi Garavelli, Diego Barillà, Francesco Cattel, Giovanni Di Perri, Giovannino Ciccone, Tommaso Lupia, and Silvia Corcione. 2021. "Risk Factors for Mortality in COVID-19 Hospitalized Patients in Piedmont, Italy: Results from the Multicenter, Regional, CORACLE Registry" Journal of Clinical Medicine 10, no. 9: 1951. https://doi.org/10.3390/jcm10091951

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