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Article

Diagnostic Performance of the Fujifilm SILVAMP TB-LAM in Children with Presumptive Tuberculosis

1
Institut d’Investigació Germans Trias i Pujol, CIBER Enfermedades Respiratorias, Universitat Autònoma de Barcelona, 08916 Barcelona, Spain
2
Department of Pediatrics, Division of Tuberculosis, Hôpital Saint-Damien, Nos Petits-Frères et Sœurs, Port-au-Prince 6112, Haiti
3
Department of Radiology and Imaging Diagnose, Centre d’Atenció Primària (CAP) Manso, 08015 Barcelona, Spain
4
Servei de Pediatria, Atenció Primària, Unitat de Investigació Fundació Mútua Terrassa, Hospital Universitari Mútua Terrassa, 08221 Barcelona, Spain
5
Stop TB Partnership, TB Reach, 1218 Geneva, Switzerland
6
Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
*
Author to whom correspondence should be addressed.
Senior co-authors.
Academic Editor: Luis Garcia-Marcos
J. Clin. Med. 2021, 10(9), 1914; https://doi.org/10.3390/jcm10091914
Received: 24 March 2021 / Revised: 17 April 2021 / Accepted: 23 April 2021 / Published: 28 April 2021
(This article belongs to the Section Infectious Diseases)
Current diagnostics for tuberculosis (TB) only manage to confirm a small proportion of children with TB and require respiratory samples, which are difficult to obtain. There is a need for non-invasive biomarker-based tests as an alternative to sputum testing. Fujifilm SILVAMP TB lipoarabinomannan (FujiLAM), a lateral-flow test to detect lipoarabinomannan in urine, is a novel non-sputum-based point-of-care diagnostic reported to have increased sensitivity for the diagnosis of TB among human immunodeficiency virus (HIV)-infected adults. We evaluate the performance of FujiLAM in children with presumptive TB. Fifty-nine children attending a paediatric hospital in Haiti with compatible signs and symptoms of TB were examined using Xpert MTB/RIF, smear microscopy and X-rays, and classified according to the certainty of diagnosis into bacteriologically confirmed TB (n = 5), unconfirmed TB (bacteriologically negative, n = 50) and unlikely TB (n = 4). Healthy children (n = 20) were enrolled as controls. FujiLAM sensitivity and specificity were 60% and 95% among children with confirmed TB. FujiLAM’s high specificity and its characteristics as a point-of-care indicate the test has a good potential for the diagnosis of TB in children. View Full-Text
Keywords: tuberculosis; diagnosis; lipoarabinomannan; LAM; children; urine; point-of-care tuberculosis; diagnosis; lipoarabinomannan; LAM; children; urine; point-of-care
MDPI and ACS Style

Comella-del-Barrio, P.; Molina-Moya, B.; Gautier, J.; Villar-Hernández, R.; Doresca, M.J.C.; Sallés-Mingels, B.; Canales-Aliaga, L.; Narcisse, M.; Pérez-Porcuna, T.M.; Creswell, J.; Cuevas, L.E.; Domínguez, J. Diagnostic Performance of the Fujifilm SILVAMP TB-LAM in Children with Presumptive Tuberculosis. J. Clin. Med. 2021, 10, 1914. https://doi.org/10.3390/jcm10091914

AMA Style

Comella-del-Barrio P, Molina-Moya B, Gautier J, Villar-Hernández R, Doresca MJC, Sallés-Mingels B, Canales-Aliaga L, Narcisse M, Pérez-Porcuna TM, Creswell J, Cuevas LE, Domínguez J. Diagnostic Performance of the Fujifilm SILVAMP TB-LAM in Children with Presumptive Tuberculosis. Journal of Clinical Medicine. 2021; 10(9):1914. https://doi.org/10.3390/jcm10091914

Chicago/Turabian Style

Comella-del-Barrio, Patricia, Bárbara Molina-Moya, Jacqueline Gautier, Raquel Villar-Hernández, Mariette J.C. Doresca, Beatriz Sallés-Mingels, Lydia Canales-Aliaga, Margareth Narcisse, Tomás M. Pérez-Porcuna, Jacob Creswell, Luis E. Cuevas, and José Domínguez. 2021. "Diagnostic Performance of the Fujifilm SILVAMP TB-LAM in Children with Presumptive Tuberculosis" Journal of Clinical Medicine 10, no. 9: 1914. https://doi.org/10.3390/jcm10091914

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