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Review

Methodological Aspects of Randomized Controlled Trials for Tinnitus: A Systematic Review and How a Decision Support System Could Overcome Barriers

1
First Department of Otorhinolaryngology, Head and Neck Surgery, Hippokration General Hospital, National and Kapodistrian University of Athens, 15772 Athens, Greece
2
Department of Psychiatry and Psychotherapy, Universität Regensburg, 93053 Regensburg, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Christof Röösli
J. Clin. Med. 2021, 10(8), 1737; https://doi.org/10.3390/jcm10081737
Received: 1 March 2021 / Revised: 8 April 2021 / Accepted: 8 April 2021 / Published: 16 April 2021
(This article belongs to the Special Issue Novel Treatments and Diagnosis for Chronic Tinnitus)
Although a wide range of tinnitus management interventions is currently under research and a variety of therapeutic interventions have already been applied in clinical practice, no optimal and universal tinnitus treatment has been reached yet. This fact is to some extent a consequence of the high heterogeneity of the methodologies used in tinnitus related clinical studies. In this manuscript, we have identified, summarized, and critically appraised tinnitus-related randomized clinical trials since 2010, aiming at systematically mapping the research conducted in this area. The results of our analysis of the 73 included randomized clinical trials provide important insight on the identification of limitations of previous works, methodological pitfalls or gaps in current knowledge, a prerequisite for the adequate interpretation of current literature and execution of future studies. View Full-Text
Keywords: tinnitus; tinnitus treatment; randomized controlled trial tinnitus; tinnitus treatment; randomized controlled trial
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MDPI and ACS Style

Kikidis, D.; Vassou, E.; Schlee, W.; Iliadou, E.; Markatos, N.; Triantafyllou, A.; Langguth, B. Methodological Aspects of Randomized Controlled Trials for Tinnitus: A Systematic Review and How a Decision Support System Could Overcome Barriers. J. Clin. Med. 2021, 10, 1737. https://doi.org/10.3390/jcm10081737

AMA Style

Kikidis D, Vassou E, Schlee W, Iliadou E, Markatos N, Triantafyllou A, Langguth B. Methodological Aspects of Randomized Controlled Trials for Tinnitus: A Systematic Review and How a Decision Support System Could Overcome Barriers. Journal of Clinical Medicine. 2021; 10(8):1737. https://doi.org/10.3390/jcm10081737

Chicago/Turabian Style

Kikidis, Dimitrios, Evgenia Vassou, Winfried Schlee, Eleftheria Iliadou, Nikolaos Markatos, Aikaterini Triantafyllou, and Berthold Langguth. 2021. "Methodological Aspects of Randomized Controlled Trials for Tinnitus: A Systematic Review and How a Decision Support System Could Overcome Barriers" Journal of Clinical Medicine 10, no. 8: 1737. https://doi.org/10.3390/jcm10081737

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