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Article

Physicochemical Properties of Lipoproteins Assessed by Nuclear Magnetic Resonance as a Predictor of Premature Cardiovascular Disease. PRESARV-SEA Study

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Bioquímica Especial y Biología Molecular, Laboratori Clínic, Hospital Universitario de Bellvitge, 08907 L’Hospitalet de Ll., Spain
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Clinical Laboratory, SCIAS-Hospital de Barcelona, 08034 Barcelona, Spain
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Biosfer Teslab, 43204 Reus, Spain
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CIBERDEM, Universidad Rovira i Virgili, 43002 Tarragona, Spain
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Unidad de Lípidos y Riesgo Vascular, Servicio de Medicina Interna, Hospital Universitario de Bellvitge-IDIBELL, 08907 Barcelona, Spain
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Centro de Investigación Biomédica en Red, Fisiopatologia de la Obesidad y Nutrición CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain
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EAP Sardenya, Instituto de Investigaciones Biomédicas Sant Pau, 08025 Barcelona, Spain
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Hospital Universitario Dr. Peset, 46017 Valencia, Spain
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Servicio de Bioquímica Clínica, Hospital Universitario Miguel Servet, CIBERCV IIS Aragón, Universidad de Zaragoza, 50009 Zaragoza, Spain
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Hospital General San Pedro, 26006 Logroño, Spain
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Hospital de Terrassa (Consorci Sanitari de Terrassa), 08227 Terrassa, Spain
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Departamento de Esepecialidades Médicas y Salud Pública, Unidad de Medicina Interna, Hospital Universitario Fundación Alcorcón, Universidad Rey Juan Carlos, 28922 Alcorcón, Spain
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Hospital de Figueres (Fundació Salut Empordà), 17600 Figueres, Spain
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Hospital Universitario Virgen de la Victoria, IBIMA, Universidad de Málaga, 29010 Málaga, Spain
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Facultad de Medicina y Ciencias de la Salud, Universitat Internacional de Catalunya, 08017 Barcelona, Spain
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Department of Medicine, Campus Bellvitge, Universidad de Barcelona, 08907 L’Hospitalet de Ll., Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Principal investigator of PRESAV-SEA group.
Academic Editor: Vanessa Bianconi
J. Clin. Med. 2021, 10(7), 1379; https://doi.org/10.3390/jcm10071379
Received: 22 February 2021 / Revised: 16 March 2021 / Accepted: 26 March 2021 / Published: 29 March 2021
(This article belongs to the Section Cardiology)
Some lipoprotein disorders related to the residual risk of premature cardiovascular disease (PCVD) are not detected by the conventional lipid profile. In this case-control study, the predictive power of PCVD of serum sdLDL-C, measured using a lipoprotein precipitation method, and of the physicochemical properties of serum lipoproteins, analyzed by nuclear magnetic resonance (NMR) techniques, were evaluated. We studied a group of patients with a first PCVD event (n = 125) and a group of control subjects (n = 190). Conventional lipid profile, the size and number of Very Low Density Lipoproteins (VLDL), Low Density Lipoproteins (LDL), High Density Lipoproteins (HDL) particles, and the number of particles of their subclasses (large, medium, and small) were measured. Compared to controls, PCVD patients had lower concentrations of all LDL particles, and smaller and larger diameter of LDL and HDL particles, respectively. PCVD patients also showed higher concentrations of small dense LDL-cholesterol (sdLDL), and triglycerides (Tg) in LDL and HDL particles (HDL-Tg), and higher concentrations of large VLDL particles. Multivariate logistic regression showed that sdLDL-C, HDL-Tg, and large concentrations of LDL particles were the most powerful predictors of PCVD. A strong relationship was observed between increased HDL-Tg concentrations and PCVD. This study demonstrates that beyond the conventional lipid profile, PCVD patients have other atherogenic lipoprotein alterations that are detected by magnetic resonance imaging (MRI) analysis. View Full-Text
Keywords: NMR analysis of lipoproteins; lipid profile; premature cardiovascular disease; residual cardiovascular risk; small dense LDL; lipoprotein particle number; lipoprotein precipitation NMR analysis of lipoproteins; lipid profile; premature cardiovascular disease; residual cardiovascular risk; small dense LDL; lipoprotein particle number; lipoprotein precipitation
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MDPI and ACS Style

Fernández-Cidón, B.; Candás-Estébanez, B.; Gil-Serret, M.; Amigó, N.; Corbella, E.; Rodríguez-Sánchez, M.Á.; Padró-Miquel, A.; Brotons, C.; Hernández-Mijares, A.; Calmarza, P.; Jarauta, E.; Brea, A.J.; Mauri, M.; Guijarro, C.; Vila, À.; Valdivielso, P.; Corbella, X.; Pintó, X. Physicochemical Properties of Lipoproteins Assessed by Nuclear Magnetic Resonance as a Predictor of Premature Cardiovascular Disease. PRESARV-SEA Study. J. Clin. Med. 2021, 10, 1379. https://doi.org/10.3390/jcm10071379

AMA Style

Fernández-Cidón B, Candás-Estébanez B, Gil-Serret M, Amigó N, Corbella E, Rodríguez-Sánchez MÁ, Padró-Miquel A, Brotons C, Hernández-Mijares A, Calmarza P, Jarauta E, Brea AJ, Mauri M, Guijarro C, Vila À, Valdivielso P, Corbella X, Pintó X. Physicochemical Properties of Lipoproteins Assessed by Nuclear Magnetic Resonance as a Predictor of Premature Cardiovascular Disease. PRESARV-SEA Study. Journal of Clinical Medicine. 2021; 10(7):1379. https://doi.org/10.3390/jcm10071379

Chicago/Turabian Style

Fernández-Cidón, Bárbara, Beatriz Candás-Estébanez, Miriam Gil-Serret, Núria Amigó, Emili Corbella, M. Á. Rodríguez-Sánchez, Ariadna Padró-Miquel, Carlos Brotons, Antonio Hernández-Mijares, Pilar Calmarza, Estibaliz Jarauta, Angel J. Brea, Marta Mauri, Carlos Guijarro, Àlex Vila, Pedro Valdivielso, Xavier Corbella, and Xavier Pintó. 2021. "Physicochemical Properties of Lipoproteins Assessed by Nuclear Magnetic Resonance as a Predictor of Premature Cardiovascular Disease. PRESARV-SEA Study" Journal of Clinical Medicine 10, no. 7: 1379. https://doi.org/10.3390/jcm10071379

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