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Brief Report

Reduced Flow-Mediated Dilatation Is Not Related to COVID-19 Severity Three Months after Hospitalization for SARS-CoV-2 Infection

1
Team 3072 “Mitochondria, Oxidative Stress and Muscle Protection”, Unistra, Faculty of Medicine, Translational Medicine Federation of Strasbourg (FMTS), University of Strasbourg, 11 rue Humann, 67000 Strasbourg, France
2
Physiology and Functional Exploration Service, University Hospital of Strasbourg, CHU, 1 Place de l’hôpital, 67091 Strasbourg, France
3
Department of Anesthesiology and Surgical Critical Care, University Hospital of Strasbourg, 1 Place de l’hôpital, 67091 Strasbourg, France
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Department of Pneumology, University Hospital of Strasbourg, 1 Place de l’hôpital, 67091 Strasbourg, France
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Department of Internal Medicine, University Hospital of Strasbourg, 1 Place de l’hôpital, 67091 Strasbourg, France
*
Author to whom correspondence should be addressed.
Academic Editor: Olivier Morel
J. Clin. Med. 2021, 10(6), 1318; https://doi.org/10.3390/jcm10061318
Received: 20 January 2021 / Revised: 16 March 2021 / Accepted: 18 March 2021 / Published: 23 March 2021
(This article belongs to the Special Issue Vascular Damage and Coagulopathy during COVID-19 Infections)
The coronavirus disease 2019 (COVID-19) pandemic has spread rapidly worldwide, with more than two million deaths. Evidence indicates the critical role of the vascular endothelium in its pathophysiology but, like potential changes in functional vasodilation, the vascular effect of SARS-CoV-2 at a given distance from the acute infection is largely unknown. We assessed brachial artery flow-mediated dilatation (FMD) in 27 COVID-19 patients needing conventional or intensive care unit hospitalization, three months after SARS-CoV-2 infection diagnosis and in nine age- and sex- matched control subjects. Interestingly, the FMD was lower in COVID-19 patients as compared to controls (8.2 (7.2–8.9) vs. 10.3 (9.1–11.7)); p = 0.002, and half of the hospitalized COVID-19 survivors presented with a reduced FMD < 8% at three months of COVID-19 onset. Impaired FMD was not associated with severe or critical SARS-CoV-2 infection, reflected by ICU hospitalization, total hospitalization duration, or severity of lung damage. In conclusion, reduced FMD is often observed even three months after hospitalization for SARS-CoV-2 infection, but such alteration predominantly appears to not be related to COVID-19 severity. Longer and larger follow-up studies will help to clarify the potential prognosis value of FMD among COVID-19 patients, as well as to further determine the mechanisms involved. View Full-Text
Keywords: COVID-19; vascular function; flow-mediated dilatation COVID-19; vascular function; flow-mediated dilatation
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MDPI and ACS Style

Riou, M.; Oulehri, W.; Momas, C.; Rouyer, O.; Lebourg, F.; Meyer, A.; Enache, I.; Pistea, C.; Charloux, A.; Marcot, C.; de Blay, F.; Collange, O.; Mertes, M.; Andrès, E.; Talha, S.; Geny, B. Reduced Flow-Mediated Dilatation Is Not Related to COVID-19 Severity Three Months after Hospitalization for SARS-CoV-2 Infection. J. Clin. Med. 2021, 10, 1318. https://doi.org/10.3390/jcm10061318

AMA Style

Riou M, Oulehri W, Momas C, Rouyer O, Lebourg F, Meyer A, Enache I, Pistea C, Charloux A, Marcot C, de Blay F, Collange O, Mertes M, Andrès E, Talha S, Geny B. Reduced Flow-Mediated Dilatation Is Not Related to COVID-19 Severity Three Months after Hospitalization for SARS-CoV-2 Infection. Journal of Clinical Medicine. 2021; 10(6):1318. https://doi.org/10.3390/jcm10061318

Chicago/Turabian Style

Riou, Marianne, Walid Oulehri, Cedric Momas, Olivier Rouyer, Fabienne Lebourg, Alain Meyer, Irina Enache, Cristina Pistea, Anne Charloux, Christophe Marcot, Frederic de Blay, Olivier Collange, Michel Mertes, Emmanuel Andrès, Samy Talha, and Bernard Geny. 2021. "Reduced Flow-Mediated Dilatation Is Not Related to COVID-19 Severity Three Months after Hospitalization for SARS-CoV-2 Infection" Journal of Clinical Medicine 10, no. 6: 1318. https://doi.org/10.3390/jcm10061318

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