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Review

Roles of Microglial Ion Channel in Neurodegenerative Diseases

1
Department of Physiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
2
Experimental Research Center for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
3
Pain Center, Department of Anesthesiology, Lausanne University Hospital (CHUV), CH-1011 Lausanne, Switzerland
4
Faculty of Biology and Medicine (FBM), University of Lausanne (UNIL), CH-1011 Lausanne, Switzerland
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Chair of Vascular Neurology, Dementia and Ageing Research, University Hospital Essen, 45147 Essen, Germany
6
Department of Biophysics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
*
Authors to whom correspondence should be addressed.
Authors with equal contribution.
Academic Editor: Angeles Almeida
J. Clin. Med. 2021, 10(6), 1239; https://doi.org/10.3390/jcm10061239
Received: 5 February 2021 / Revised: 2 March 2021 / Accepted: 11 March 2021 / Published: 17 March 2021
As the average age and life expectancy increases, the incidence of both acute and chronic central nervous system (CNS) pathologies will increase. Understanding mechanisms underlying neuroinflammation as the common feature of any neurodegenerative pathology, we can exploit the pharmacology of cell specific ion channels to improve the outcome of many CNS diseases. As the main cellular player of neuroinflammation, microglia play a central role in this process. Although microglia are considered non-excitable cells, they express a variety of ion channels under both physiological and pathological conditions that seem to be involved in a plethora of cellular processes. Here, we discuss the impact of modulating microglia voltage-gated, potential transient receptor, chloride and proton channels on microglial proliferation, migration, and phagocytosis in neurodegenerative diseases. View Full-Text
Keywords: microglia; ion channel; neurodegeneration; cerebral ischemia; alzheimer’s disease; parkinson disease; multiple sclerosis; Lateral amyloid sclerosis; epilepsy microglia; ion channel; neurodegeneration; cerebral ischemia; alzheimer’s disease; parkinson disease; multiple sclerosis; Lateral amyloid sclerosis; epilepsy
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MDPI and ACS Style

Cojocaru, A.; Burada, E.; Bălșeanu, A.-T.; Deftu, A.-F.; Cătălin, B.; Popa-Wagner, A.; Osiac, E. Roles of Microglial Ion Channel in Neurodegenerative Diseases. J. Clin. Med. 2021, 10, 1239. https://doi.org/10.3390/jcm10061239

AMA Style

Cojocaru A, Burada E, Bălșeanu A-T, Deftu A-F, Cătălin B, Popa-Wagner A, Osiac E. Roles of Microglial Ion Channel in Neurodegenerative Diseases. Journal of Clinical Medicine. 2021; 10(6):1239. https://doi.org/10.3390/jcm10061239

Chicago/Turabian Style

Cojocaru, Alexandru, Emilia Burada, Adrian-Tudor Bălșeanu, Alexandru-Florian Deftu, Bogdan Cătălin, Aurel Popa-Wagner, and Eugen Osiac. 2021. "Roles of Microglial Ion Channel in Neurodegenerative Diseases" Journal of Clinical Medicine 10, no. 6: 1239. https://doi.org/10.3390/jcm10061239

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