Quality of Recovery after Laparoscopic Cholecystectomy Following Neuromuscular Blockade Reversal with Neostigmine or Sugammadex: A Prospective, Randomized, Controlled Trial
Abstract
1. Introduction
2. Materials and Methods
Statistical Analyses
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Appendix A
1. | Able to breathe easy |
2. | Been able to enjoy food |
3. | Feeling rested |
4. | Have had a good sleep |
5. | Able to look after personal toilet and hygiene unaided |
6. | Able to communicate with family or friends |
7. | Getting support from hospital doctors and nurse |
8. | Able to return to work or usual home activities |
9. | Feeling comfortable and in control |
10. | Having a feeling of general well-being |
11. | Moderate pain |
12. | Severe pain |
13. | Nausea or vomiting |
14. | Feeling worried or anxious |
15. | Feeling sad or depressed |
Appendix B
Appendix C
Neostigmine | Sugammadex | p-Value | |||||||
---|---|---|---|---|---|---|---|---|---|
Preop n = 38 | POD1 n = 38 | POD2 n = 38 | Preop n = 39 | POD1 n = 39 | POD2 n = 37 | Preop | POD1 | POD2 | |
Physical comfort | |||||||||
Breath | 9.7 ± 0.7 | 8.2 ± 2.7 | 8.7 ± 2.4 | 9.6 ± 1.0 | 7.5 ± 2.6 | 9.4 ± 1.0 | 0.73 | 0.21 | 0.11 |
Eat | 8.0 ± 3.3 | 5.2 ± 4.0 | 7.0 ± 3.0 | 8.9 ± 2.1 | 5.1 ± 3.9 | 7.7 ± 2.5 | 0.19 | 0.84 | 0.31 |
Rest | 8.8 ± 2.0 | 5.7 ± 3.3 | 7.9 ± 2.6 | 9.3 ± 1.4 | 6.4 ± 3.0 | 8.5 ± 1.5 | 0.20 | 0.33 | 0.21 |
Sleep | 8.3 ± 2.3 | 5.9 ± 3.2 | 7.7 ± 2.6 | 8.3 ± 2.1 | 6.1 ± 3.0 | 8.5 ± 1.4 | 0.97 | 0.86 | 0.13 |
Nausea | 8.1 ± 2.9 | 7.1 ± 3.5 | 7.8 ± 3.2 | 8.9 ± 2.5 | 6.7 ± 3.4 | 7.7 ± 3.0 | 0.21 | 0.56 | 0.93 |
Physical independence | |||||||||
Wash | 9.3 ± 1.5 | 6.2 ± 3.6 | 8.2 ± 2.5 | 9.6 ± 1.0 | 6.1 ± 3.6 | 8.3 ± 1.9 | 0.35 | 0.82 | 0.79 |
Work | 8.7 ± 2.7 | 3.0 ± 3.5 | 5.9 ± 3.5 | 8.8 ± 2.4 | 3.8 ± 3.5 | 6.1 ± 3.0 | 0.12 | 0.30 | 0.72 |
Pain | |||||||||
Moderate pain | 7.1 ± 3.1 | 3.2 ± 3.0 | 6.1 ± 2.6 | 8.0 ± 2.3 | 3.6 ± 3.0 | 5.5 ± 2.3 | 0.16 | 0.51 | 0.34 |
Severe pain | 8.3 ± 2.8 | 4.9 ± 2.9 | 7.1 ± 3.2 | 8.6 ± 2.3 | 5.0 ± 3.1 | 7.1 ± 2.2 | 0.67 | 0.94 | 0.96 |
Psychological support | |||||||||
Talk | 9.5 ± 1.1 | 7.3 ± 3.0 | 8.7 ± 2.2 | 9.6 ± 1.1 | 7.4 ± 2.9 | 9.0 ± 1.6 | 0.58 | 0.92 | 0.45 |
Help | 9.6 ± 1.0 | 9.0 ± 2.0 | 9.1 ± 2.0 | 9.7 ± 0.6 | 9.1 ± 1.8 | 9.0 ± 2.0 | 0.39 | 0.77 | 0.78 |
Emotional state | |||||||||
Emotion | 9.2 ± 1.4 | 7.7 ± 2.8 | 8.5 ± 2.4 | 9.3 ± 1.3 | 8.4 ± 1.9 | 9.0 ± 1.3 | 0.62 | 0.17 | 0.22 |
Well-being | 8.7 ± 2.0 | 5.8 ± 3.0 | 7.6 ± 2.7 | 8.5 ± 1.6 | 5.9 ± 2.7 | 8.1 ± 1.6 | 0.68 | 0.87 | 0.31 |
Anxiety | 7.7 ± 2.5 | 7.1 ± 3.2 | 8.2 ± 2.9 | 83 ± 2.3 | 6.8 ± 3.1 | 8.9 ± 1.7 | 0.32 | 0.72 | 0.22 |
Depression | 8.5 ± 2.3 | 8.0 ± 2.5 | 7.8 ± 3.1 | 8.3 ± 2.2 | 7.4 ± 2.8 | 9.0 ± 1.5 | 0.71 | 0.30 | 0.41 |
Total | 129.3 ± 25.2 | 94.4 ± 30.7 | 116.3 ± 31.1 | 133.6 ± 16.5 | 95.5 ± 27.7 | 122 ± 17.3 | 0.38 | 0.87 | 0.33 |
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Neostigmine, n = 38 | Sugammadex, n = 39 | |
---|---|---|
Age (years) | 51.3 ± 11.5 | 54.1 ± 10.7 |
Weight (kg) | 69.1 ± 12.5 | 68.1 ± 15.5 |
Height (cm) | 164.5 ± 9.1 | 166.6 ± 8.6 |
Sex; male | 18 (47.4%) | 22 ± 56.4% |
Operation time (min) | 41.2 ± 19.2 | 43.0 ± 21.2 |
Anesthesia time (min) | 58.3 ± 22.2 | 63.6 ± 22.6 |
Diagnosis | ||
Chronic cholecystitis | 16 (42.1%) | 23 (59%) |
Acute cholecystitis | 12 (31.6%) | 10 (25.6%) |
Acute pancreatitis | 2 (5.3%) | 0 (0%) |
GB Polyp | 6 (15.8%) | 5 (12.8%) |
GB Adenomatosis | 1 (2.6%) | 1 (2.6%) |
GB stone | 1 (2.6%) | 0 (0%) |
ASA physical status | ||
1 | 18 (47.4%) | 15 (38.5%) |
2 | 18 (47.4%) | 19 (48.7%) |
3 | 2 (5.3%) | 5 (12.8%) |
Hypertension | 12 (31.6%) | 9 (23.1%) |
Diabetes mellitus | 4 (10.5%) | 6 (15.4%) |
Coronary artery disease | 3 (7.9%) | 8 (20.5%) |
Cerebral vascular disease | 1 (2.6%) | 2 (5.1%) |
Cancer | 6 (15.8%) | 10 (25.6%) |
Neostigmine, n = 38 | Sugammadex, n = 39 | p-Value | |
---|---|---|---|
Modified Aldrete score | 7.5 ± 0.6 | 7.4 ± 0.5 | 0.48 |
PACU stay (min) | 27.7 ± 8.7 | 29.8 ± 9.4 | 0.32 |
Pain score (NRS) | |||
30 min | 6.5 ± 1.4 | 6.6 ± 1.2 | 0.76 |
6 h | 3.6 ± 1.1 | 3.4 ± 1.0 | 0.41 |
24 h | 3.0 ± 0.7 | 2.9 ± 0.6 | 0.22 |
Rescue analgesics * | 3.2 ± 1.9 | 3.3 ± 1.2 | 0.79 |
Morphine equivalent dose (mg) | 14.5 ± 7.3 | 15.6 ± 6.2 | 0.46 |
Rescue anti-emetics * | 0.4 ± 0.7 | 0.4 ± 0.7 | 0.92 |
Urinary retention | 6 (15.8%) | 1 (2.6%) | 0.04 † |
Length of hospital stay (days) | 3.5 ± 0.95 | 3.7 ± 1.0 | 0.29 |
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Han, J.; Oh, A.-Y.; Jeon, Y.-T.; Koo, B.-W.; Kim, B.Y.; Kim, D.; Hwang, I. Quality of Recovery after Laparoscopic Cholecystectomy Following Neuromuscular Blockade Reversal with Neostigmine or Sugammadex: A Prospective, Randomized, Controlled Trial. J. Clin. Med. 2021, 10, 938. https://doi.org/10.3390/jcm10050938
Han J, Oh A-Y, Jeon Y-T, Koo B-W, Kim BY, Kim D, Hwang I. Quality of Recovery after Laparoscopic Cholecystectomy Following Neuromuscular Blockade Reversal with Neostigmine or Sugammadex: A Prospective, Randomized, Controlled Trial. Journal of Clinical Medicine. 2021; 10(5):938. https://doi.org/10.3390/jcm10050938
Chicago/Turabian StyleHan, Jiwon, Ah-Young Oh, Yong-Tae Jeon, Bon-Wook Koo, Bo Young Kim, Donghyun Kim, and Insung Hwang. 2021. "Quality of Recovery after Laparoscopic Cholecystectomy Following Neuromuscular Blockade Reversal with Neostigmine or Sugammadex: A Prospective, Randomized, Controlled Trial" Journal of Clinical Medicine 10, no. 5: 938. https://doi.org/10.3390/jcm10050938
APA StyleHan, J., Oh, A.-Y., Jeon, Y.-T., Koo, B.-W., Kim, B. Y., Kim, D., & Hwang, I. (2021). Quality of Recovery after Laparoscopic Cholecystectomy Following Neuromuscular Blockade Reversal with Neostigmine or Sugammadex: A Prospective, Randomized, Controlled Trial. Journal of Clinical Medicine, 10(5), 938. https://doi.org/10.3390/jcm10050938