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Article

Oxidative Stress Reduction by Midazolam Premedication during Oocyte Retrieval Procedure: Pilot Study

1
Department of Anesthesiology, Intensive Care Medicine and Pain Management, University Hospital Center “Sestre milosrdnice”, HR-10000 Zagreb, Croatia
2
Department of Gynecology and Obstetrics, University Hospital Center “Sestre Milosrdnice”, HR-10000 Zagreb, Croatia
3
Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Center “Sestre Milosrdnice”, HR-10000 Zagreb, Croatia
4
Division of Molecular Medicine, Ruđer Bošković Institute, HR-10000 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
Academic Editor: Alberto Ferlin
J. Clin. Med. 2021, 10(4), 855; https://doi.org/10.3390/jcm10040855
Received: 7 January 2021 / Revised: 8 February 2021 / Accepted: 17 February 2021 / Published: 19 February 2021
(This article belongs to the Section Anesthesiology)
Infertility is one of the major medical problems nowadays. Couples who opt for In Vitro Fertilization (IVF) face a great deal of stress which certainly affects the outcome of the procedure. Therefore, we aimed to reduce the stress during the oocyte retrieval procedure by applying midazolam. Total oxidant (TOC) and antioxidant (TAC) capacities of serum, as well as glutathione (GSH) content and catalase activity, were measured in both control and midazolam groups. Follicular fluid was also tested for oxidant capacity and IL1β. Results implied that the midazolam group increased TAC at the end of the procedure. At the same time, the control group decreased GSH at the beginning of the procedure, and both groups decreased catalase activity at the end of the procedure. The results imply that stress during the procedure affects oxidative and antioxidative parameters of the patients, but did not affect the frequency of the pregnancy at the end of this pilot study. Yet, the results imply that oxidative and antioxidative mechanisms during IVF should be investigated in detail as they could affect the outcome of IVF. View Full-Text
Keywords: oocyte retrieval; midazolam; oxidative stress oocyte retrieval; midazolam; oxidative stress
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MDPI and ACS Style

Pešić, M.; Kličan-Jaić, K.; Vučić, M.; Kuna, K.; Košec, A.; Čipak Gašparović, A. Oxidative Stress Reduction by Midazolam Premedication during Oocyte Retrieval Procedure: Pilot Study. J. Clin. Med. 2021, 10, 855. https://doi.org/10.3390/jcm10040855

AMA Style

Pešić M, Kličan-Jaić K, Vučić M, Kuna K, Košec A, Čipak Gašparović A. Oxidative Stress Reduction by Midazolam Premedication during Oocyte Retrieval Procedure: Pilot Study. Journal of Clinical Medicine. 2021; 10(4):855. https://doi.org/10.3390/jcm10040855

Chicago/Turabian Style

Pešić, Maja, Katarina Kličan-Jaić, Marinko Vučić, Krunoslav Kuna, Andro Košec, and Ana Čipak Gašparović. 2021. "Oxidative Stress Reduction by Midazolam Premedication during Oocyte Retrieval Procedure: Pilot Study" Journal of Clinical Medicine 10, no. 4: 855. https://doi.org/10.3390/jcm10040855

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