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Percutaneous Mitral Valve Repair: Outcome Improvement with Operator Experience and a Second-Generation Device

Hospital Clinic de Barcelona, Institut Clínic Cardiovascular, 08036 Barcelona, Spain
Hospital Universitario de León, 24071 León, Spain
Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain
Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain
Hospital Clínico Universitario de Valladolid, 47003 Valladolid, Spain
Hospital Clínico de San Carlos, 28040 Madrid, Spain
Hospital Central de Asturias, 33011 Oviedo, Spain
Complejo Hospitalario Universitario de Santiago, 15706 Santiago de Compostela, Spain
Hospital Universitario Infanta Cristina, 06080 Badajoz, Spain
Hospital Ramón y Cajal, 28034 Madrid, Spain
Hospital Clínico Universitario de Salamanca, 37007 Salamanca, Spain
Hospital Civil de Basurto, 48013 Basurto, Spain
Hospital Puerta de Hierro, 28222 Madrid, Spain
Complejo Hospitalario de Navarra, 31008 Pamplona, Spain
Hospital La Fe de Valencia, 46026 Valencia, Spain
Hospital General Universitario de Valencia, 46014 Valencia, Spain
Complejo Hospitalario Universidad de Vigo, 36310 Vigo, Spain
Hospital Reina Sofía de Córdoba, 14004 Córdoba, Spain
Author to whom correspondence should be addressed.
Academic Editor: Emmanuel Andrès
J. Clin. Med. 2021, 10(4), 734;
Received: 21 December 2020 / Revised: 14 January 2021 / Accepted: 5 February 2021 / Published: 12 February 2021
Background and aim: Recent randomized data comparing percutaneous mitral valve repair (PMVR) versus optimal medical treatment in patients with functional MR (FMR) seemed to highlight the importance of the learning curve not only for procedural outcomes but also for patient selection. The aim of the study was to compare a contemporary series of patients undergoing PMVR using a second-generation Mitraclip device (Mitraclip NT) with previous cohorts treated with a first-generation system. Methods: This multicenter study collected individual data from 18 centers between 2012 and 2017. The cohort was divided into three groups according to the use of the first-generation Mitraclip during the first (control-1) or second half (control-2) or the Mitraclip NT system. Results: A total of 545 consecutive patients were included in the study. Among all, 182 (33.3%), 183 (33.3%), and 180 (33.3%) patients underwent mitral repair in the control-1, control-2, and NT cohorts, respectively. Procedural success was achieved in 93.3% of patients without differences between groups. Major adverse events did not statistically differ among groups, but there was a higher rate of pericardial effusion in the control-1 group (4.3%, 0.6%, and 2.6%, respectively; p = 0.025). The composite endpoint of death, surgery, and admission for congestive heart failure (CHF) at 12 months was lower in the NT group (23.5% in control-1, 22.5% in control-2, and 8.3% in the NT group; p = 0.032). Conclusions: The present paper shows that contemporary clinical outcomes of patients undergoing PMVR with the Mitraclip system have improved over time. View Full-Text
Keywords: transcatheter mitral valve repair; mitral regurgitation; MitraClip transcatheter mitral valve repair; mitral regurgitation; MitraClip
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MDPI and ACS Style

Freixa, X.; Estévez-Loureiro, R.; Carrasco-Chinchilla, F.; Millán, X.; Amat-Santos, I.; Regueiro, A.; Nombela-Franco, L.; Pascual, I.; Cid, B.; López-Mínguez, J.R.; Hernández-Antolín, R.A.; Cruz-González, I.; Andraka, L.; Goicolea, J.; Ruíz-Quevedo, V.; Díez, J.L.; Berenguer, A.; Baz, J.A.; Pan, M.; Benito-González, T.; Briales, J.H.A.; Li, C.H.; Sanchis, L.; Serrador, A.; Jiménez-Quevedo, P.; Avanzas, P.; Salido, L.; Fernández-Vázquez, F.; Hernández-García, J.M.; Arzamendi, D. Percutaneous Mitral Valve Repair: Outcome Improvement with Operator Experience and a Second-Generation Device. J. Clin. Med. 2021, 10, 734.

AMA Style

Freixa X, Estévez-Loureiro R, Carrasco-Chinchilla F, Millán X, Amat-Santos I, Regueiro A, Nombela-Franco L, Pascual I, Cid B, López-Mínguez JR, Hernández-Antolín RA, Cruz-González I, Andraka L, Goicolea J, Ruíz-Quevedo V, Díez JL, Berenguer A, Baz JA, Pan M, Benito-González T, Briales JHA, Li CH, Sanchis L, Serrador A, Jiménez-Quevedo P, Avanzas P, Salido L, Fernández-Vázquez F, Hernández-García JM, Arzamendi D. Percutaneous Mitral Valve Repair: Outcome Improvement with Operator Experience and a Second-Generation Device. Journal of Clinical Medicine. 2021; 10(4):734.

Chicago/Turabian Style

Freixa, Xavier, Rodrigo Estévez-Loureiro, Fernando Carrasco-Chinchilla, Xavier Millán, Ignacio Amat-Santos, Ander Regueiro, Luis Nombela-Franco, Isaac Pascual, Belen Cid, José R. López-Mínguez, Rosa A. Hernández-Antolín, Ignacio Cruz-González, Leire Andraka, Javier Goicolea, Valeriano Ruíz-Quevedo, Jose L. Díez, Alberto Berenguer, José A. Baz, Manuel Pan, Tomas Benito-González, Juan H.A. Briales, Chi H. Li, Laura Sanchis, Ana Serrador, Pilar Jiménez-Quevedo, Pablo Avanzas, Luisa Salido, Felipe Fernández-Vázquez, José M. Hernández-García, and Dabit Arzamendi. 2021. "Percutaneous Mitral Valve Repair: Outcome Improvement with Operator Experience and a Second-Generation Device" Journal of Clinical Medicine 10, no. 4: 734.

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