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Review

First-Line Maintenance Treatment in Metastatic Colorectal Cancer (mCRC): Quality and Clinical Benefit Overview

1
Medical Oncology Department, Sant Pau Hospital, 08043 Barcelona, Spain
2
Medical Oncology Department, Quironsalud Hospital, 50006 Zaragoza, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Emmanuel Andrès and Joan Maurel
J. Clin. Med. 2021, 10(3), 470; https://doi.org/10.3390/jcm10030470
Received: 24 November 2020 / Revised: 22 December 2020 / Accepted: 21 January 2021 / Published: 26 January 2021
Different strategies of maintenance therapy (sequential CT, intermittent CT, intermittent CT and MAbs, or de-escalation MAbs monotherapy) after first-line treatment are undertaken. Many randomized clinical trials (RCT), which evaluated these approaches, suffer from incorrect design, heterogenous primary endpoints, inadequate size, and other methodology flaws. Drawing any conclusions becomes challenging and recommendations are mainly vague. We evaluated those studies from another perspective, focusing on the design quality and the clinical benefit measure with a more objective and accurate methodology. These data allowed a clearer and more exact overview of the statement in maintenance treatment. View Full-Text
Keywords: maintenance treatment; sequential; continuous; intermittent treatment maintenance treatment; sequential; continuous; intermittent treatment
MDPI and ACS Style

Martín-Richard, M.; Tobeña, M. First-Line Maintenance Treatment in Metastatic Colorectal Cancer (mCRC): Quality and Clinical Benefit Overview. J. Clin. Med. 2021, 10, 470. https://doi.org/10.3390/jcm10030470

AMA Style

Martín-Richard M, Tobeña M. First-Line Maintenance Treatment in Metastatic Colorectal Cancer (mCRC): Quality and Clinical Benefit Overview. Journal of Clinical Medicine. 2021; 10(3):470. https://doi.org/10.3390/jcm10030470

Chicago/Turabian Style

Martín-Richard, Marta, and Maria Tobeña. 2021. "First-Line Maintenance Treatment in Metastatic Colorectal Cancer (mCRC): Quality and Clinical Benefit Overview" Journal of Clinical Medicine 10, no. 3: 470. https://doi.org/10.3390/jcm10030470

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