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Article

Headache Worsening after COVID-19 Vaccination: An Online Questionnaire-Based Study on 841 Patients with Migraine

1
Headache Center, Department of Advanced Medical and Surgical Sciences (DAMS), University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
2
Intensity Care Unit, Department of Emergency and Acceptance “Antonio Cardarelli” Hospital, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Stefan Evers
J. Clin. Med. 2021, 10(24), 5914; https://doi.org/10.3390/jcm10245914
Received: 15 November 2021 / Revised: 9 December 2021 / Accepted: 12 December 2021 / Published: 16 December 2021
(This article belongs to the Special Issue Prevention and Acute Treatment of Migraine)
Vaccines have represented the breakthrough in the fight against COVID-19. Based on reported headache attacks after vaccination in randomized controlled trials, we focused on the effects of COVID-19 vaccine administration on the migraine population, using an online questionnaire published on Italian Facebook groups oriented to headache patients. We collected data about the demographics and clinical parameters of migraine severity, COVID-19 infection, vaccination, and characteristics of headaches following vaccination. Out of 841 migraine patients filling in the questionnaire, 66.47% and 60.15% patients experienced a headache attack (from 1 hour to 7 days) after the first and the second vaccine dose, respectively. The main finding concerns headaches perceived by 57.60% of patients: attacks following vaccination were referred to as more severe (50.62% of patients), long-lasting (52.80% of patients) and hardwearing (49.69% of patients) compared to the usually experienced migraine attacks. This could be related to the production of inflammatory mediators such as type Iβ interferon. Considering the high prevalence of migraine in the general population, awareness of the possibility of headaches worsening following COVID-19 vaccination in these patients may allow both patients and clinicians to face this clinical entity with conscious serenity, and to reduce the waste of resources towards inappropriate health-care. View Full-Text
Keywords: migraine with aura; migraine without aura; COVID-19; vaccine; headache migraine with aura; migraine without aura; COVID-19; vaccine; headache
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MDPI and ACS Style

Silvestro, M.; Tessitore, A.; Orologio, I.; Sozio, P.; Napolitano, G.; Siciliano, M.; Tedeschi, G.; Russo, A. Headache Worsening after COVID-19 Vaccination: An Online Questionnaire-Based Study on 841 Patients with Migraine. J. Clin. Med. 2021, 10, 5914. https://doi.org/10.3390/jcm10245914

AMA Style

Silvestro M, Tessitore A, Orologio I, Sozio P, Napolitano G, Siciliano M, Tedeschi G, Russo A. Headache Worsening after COVID-19 Vaccination: An Online Questionnaire-Based Study on 841 Patients with Migraine. Journal of Clinical Medicine. 2021; 10(24):5914. https://doi.org/10.3390/jcm10245914

Chicago/Turabian Style

Silvestro, Marcello, Alessandro Tessitore, Ilaria Orologio, Pasquale Sozio, Giuseppe Napolitano, Mattia Siciliano, Gioacchino Tedeschi, and Antonio Russo. 2021. "Headache Worsening after COVID-19 Vaccination: An Online Questionnaire-Based Study on 841 Patients with Migraine" Journal of Clinical Medicine 10, no. 24: 5914. https://doi.org/10.3390/jcm10245914

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