A Prospective Study of Association of Micronutrients Deficiencies during Pregnancy and Neonatal Outcome among Women after Bariatric Surgery
Abstract
:1. Introduction
2. Methods
2.1. Patient Selection
2.2. Management of Pregnant Women with Previous Bariatric Surgery
2.3. Maternal and Perinatal Outcome
2.4. Biological Tests
2.5. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Roux-en-Y Gastric Bypass, n = 37 (42.5%) | Sleeve Gastrectomy, n = 50 (57.5%) | p-Value | |
---|---|---|---|
Age, years | 34.3 ± 4.9 | 31.1 ± 4.6 | 0.003 |
Caucasian | 36 (97.3) | 47 (94.0) | 0.63 |
Pre-pregnancy BMI, kg/m2 | 29.8 ± 5.6 | 32.9 ± 7.1 | 0.03 |
Obesity (BMI ≥ 30 kg/m2) | 16 (43.2) | 32 (64.0) | 0.06 |
Pre-existing type 1 or 2 diabetes | 2 (5.4) | 3 (6.0) | 0.93 |
Chronic hypertension | 1 (2.7) | 1 (2.0) | 0.85 |
Smoking during pregnancy | 7 (18.9) | 19 (38.0) | 0.06 |
Time to conception from BS, months | 64.5 ± 47.0 | 38.1 ± 28.1 | 0.002 |
Nulliparity | 10 (27.0) | 16 (32.0) | 0.62 |
Gestational weight gain, kg | 10.2 ± 5.4 | 10.3 ± 4.7 | 0.87 |
Adequate weight gain during pregnancy | 25 (67.6) | 30 (60.0) | 0.47 |
GDM | 11 (29.7) | 13 (26.0) | 0.70 |
Pregnancy-induced hypertension/Pre-eclampsia | 2 (5.4) | 5 (10.0) | 0.48 |
Intrahepatic cholestasis of pregnancy | 0 | 1 (2.0) | 0.66 |
Additional supplementations after blood tests | 12 (32.4) | 16 (32.0) | 0.96 |
Gestational age at delivery, weeks | 39.2 ± 1.1 | 39.0 ± 1.8 | 0.51 |
Spontaneous labor | 19 (51.4) | 23 (46.0) | 0.63 |
Induced labor | 16 (43.2) | 16 (32.0) | 0.29 |
Mode of delivery | |||
Planned cesarean delivery before labor | 2 (5.4) | 11 (22.0) | 0.03 |
Cesarean delivery during labor | 3 (8.1) | 5 (10.0) | 0.79 |
Vaginal delivery | 32 (86.5) | 34 (68.0) | 0.05 |
Postpartum hemorrhage | 3 (8.1) | 4 (8.0) | 1.00 |
Pre-term delivery (<37 wk) | 0 | 5 (10.0) | 0.07 |
Birth weight, g | 3227 ± 499 | 3151 ± 373 | 0.42 |
Birth weight z-score | 0.2 ± 1.1 | 0.2 ± 0.9 | 0.83 |
SGA | 4 (10.8) | 3 (6.0) | 0.45 |
Birth weight < 2500 g | 3 (8.1) | 1 (2.0) | 0.23 |
LGA | 3 (8.1) | 2 (4.0) | 0.65 |
Birth weight > 4000 g | 1 (2.7) | 0 | 0.66 |
Cephalic perimeter, cm | 33.0 ± 1.7 | 33.0 ± 1.5 | 0.83 |
5 min Apgar score < 7 | 3 (8.1) | 3 (6.0) | 0.70 |
pH < 7.10 | 0 | 3 (6.0) | 0.26 |
Need for resuscitation or intubation | 0 | 0 | - |
NICU admission | 4 (10.8) | 10 (20.0) | 0.25 |
Neonatal death | 0 | 0 | - |
Neonatal morbidity | 7 (18.9) | 11 (22.0) | 0.74 |
Roux-en-Y Gastric Bypass, n = 37 (42.5%) | Sleeve Gastrectomy, n = 50 (57.5%) | p-Value | |
---|---|---|---|
Gestational age at blood samples, weeks | 27.9 ± 3.2 | 28.7 ± 2.6 | 0.18 |
Additional supplementations after blood tests | 12 (32.4) | 16 (32.0) | 0.96 |
Se (µg/L) | 66.3 ± 13.5 | 67.4 ± 10.2 | 0.68 |
Deficiency * | 8 (21.6) | 7 (14.0) | 0.36 |
Zinc (mg/L) | 1.0 ± 2.5 | 1.0 ± 2.0 | 0.93 |
Deficiency * | 7 (18.9) | 0 | 0.002 |
Vitamin A1 (µg/L) | 496.4 ± 623.6 | 503.3 ± 171.0 | 0.94 |
Deficiency * | 13 (35.1) | 12 (24.0) | 0.26 |
Vitamin B1 (µg/L) | 54.6 ± 18.2 | 55.4 ± 15.2 | 0.83 |
Deficiency * | 4 (10.8) | 2 (4.0) | 0.40 |
Vitamin B6 (µg/L) | 5.1 ± 6.5 | 3.8 ± 3.5 | 0.24 |
Deficiency * | 29 (78.4) | 44 (88.0) | 0.23 |
Vitamin C (mg/L) | 4.1 ± 3.0 | 4.8 ± 3.4 | 0.32 |
Deficiency * | 30 (81.1) | 33 (66.0) | 0.12 |
Vitamin E (mg/L) | 12.4 ± 3.6 | 13.2 ± 4.0 | 0.11 |
Deficiency * | 8 (21.6) | 4 (8.0) | 0.07 |
Variables | Birth Weight | Birth Weight Z-Score | ||
---|---|---|---|---|
Spearman’s Correlation Coefficient | p-Value | Spearman’s Correlation Coefficient | p-Value | |
Age, years | 0.010 | 0.93 | 0.012 | 0.91 |
BMI, kg/m2 | 0.188 | 0.08 | 0.191 | 0.11 |
Time to conception from BS, months | 0.126 | 0.25 | 0.047 | 0.67 |
Gestational weight gain, kg | 0.100 | 0.36 | −0.087 | 0.42 |
Selenium deficiency | −0.230 | 0.03 | −0.265 | 0.01 |
Zinc deficiency | −0.189 | 0.08 | −0.165 | 0.13 |
Vitamin A deficiency | −0.034 | 0.76 | −0.048 | 0.67 |
Vitamin B1 deficiency | −0.246 | 0.06 | −0.238 | 0.06 |
Vitamin B6 deficiency | −0.055 | 0.61 | −0.033 | 0.76 |
Vitamin C deficiency | −0.088 | 0.42 | −0.224 | 0.06 |
Vitamin E deficiency | −0.094 | 0.39 | −0.128 | 0.42 |
Gestational age at birth, weeks | 0.424 | <0.001 | −0.281 | 0.008 |
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Ducarme, G.; Planche, L.; Abet, E.; Desroys du Roure, V.; Ducet-Boiffard, A. A Prospective Study of Association of Micronutrients Deficiencies during Pregnancy and Neonatal Outcome among Women after Bariatric Surgery. J. Clin. Med. 2021, 10, 204. https://doi.org/10.3390/jcm10020204
Ducarme G, Planche L, Abet E, Desroys du Roure V, Ducet-Boiffard A. A Prospective Study of Association of Micronutrients Deficiencies during Pregnancy and Neonatal Outcome among Women after Bariatric Surgery. Journal of Clinical Medicine. 2021; 10(2):204. https://doi.org/10.3390/jcm10020204
Chicago/Turabian StyleDucarme, Guillaume, Lucie Planche, Emeric Abet, Valérie Desroys du Roure, and Amélie Ducet-Boiffard. 2021. "A Prospective Study of Association of Micronutrients Deficiencies during Pregnancy and Neonatal Outcome among Women after Bariatric Surgery" Journal of Clinical Medicine 10, no. 2: 204. https://doi.org/10.3390/jcm10020204
APA StyleDucarme, G., Planche, L., Abet, E., Desroys du Roure, V., & Ducet-Boiffard, A. (2021). A Prospective Study of Association of Micronutrients Deficiencies during Pregnancy and Neonatal Outcome among Women after Bariatric Surgery. Journal of Clinical Medicine, 10(2), 204. https://doi.org/10.3390/jcm10020204