The Netherlands Is on Track to Meet the World Health Organization Hepatitis C Elimination Targets by 2030
Abstract
:1. Introduction
2. Methods
2.1. The Model
2.2. Model Base-Case Input
2.2.1. Viraemic Prevalence
2.2.2. HCV Incidence
2.2.3. Number of Diagnosed Individuals
2.2.4. Number of Treated Individuals
2.3. Model Scenarios
2.3.1. Status Quo Scenario
2.3.2. Gradual Decline Scenario
2.3.3. COVID-19 Scenarios
3. Results
4. Discussion
5. Strengths and Limitations
6. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variable | Input | Source |
---|---|---|
Size of overall population (2016) | 16,890,864 | United Nations [15] |
Ever-infected patients with chronic HCV (up to 2016) | 23,647 | 2016 prevalence [16], adjusted to include people < 15 years old |
Total number of viraemic patients (2016) | 11,057 | Based on the adjusted 2016 prevalence [16] and the estimated number of cured patients up to 2016 |
Ever-diagnosed patients (up to 2016) | 16,533 | CELINE data (unpublished) |
Total number of diagnosed patients (2016) | 3963 | Based on CELINE data and the estimated number of cured patients up to 2016 |
Number of annual newly diagnosed patients (2016) | 700 | CELINE data (unpublished) |
Number of annual treated patients | GIP database [17] | |
2016 | 2647 | |
2017 | 1173 | |
2018 | 988 | |
2019 | 776 | |
Fibrosis stage restriction (2016) | ≥F0 | No treatment restrictions since 2016 |
Maximum age eligible for treatment (2016) | 85+ | No treatment restrictions since 2016 |
Average SVR (2016) | 95% | See Supplementary File S1 |
WHO’s Elimination Target | Year of Elimination | |
---|---|---|
Status Quo | Gradual Decline | |
65% reduction in liver-related mortality | 2020 | 2021 |
90% of infected patients diagnosed | 2027 | 2032 |
80% of eligible patients treated | 2025 | 2027 |
Year of elimination | 2027 | 2032 |
WHO’s Elimination Target | Year of Elimination |
---|---|
65% reduction in liver-related mortality | 2021 |
90% of infected patients diagnosed | >2050 |
80% of eligible patients treated | 2030 |
Year of elimination | >2050 |
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van Dijk, M.; Brakenhoff, S.M.; Isfordink, C.J.; Cheng, W.-H.; Blokzijl, H.; Boland, G.; Dofferhoff, A.S.M.; van Hoek, B.; van Nieuwkoop, C.; Sonneveld, M.J.; et al. The Netherlands Is on Track to Meet the World Health Organization Hepatitis C Elimination Targets by 2030. J. Clin. Med. 2021, 10, 4562. https://doi.org/10.3390/jcm10194562
van Dijk M, Brakenhoff SM, Isfordink CJ, Cheng W-H, Blokzijl H, Boland G, Dofferhoff ASM, van Hoek B, van Nieuwkoop C, Sonneveld MJ, et al. The Netherlands Is on Track to Meet the World Health Organization Hepatitis C Elimination Targets by 2030. Journal of Clinical Medicine. 2021; 10(19):4562. https://doi.org/10.3390/jcm10194562
Chicago/Turabian Stylevan Dijk, Marleen, Sylvia M. Brakenhoff, Cas J. Isfordink, Wei-Han Cheng, Hans Blokzijl, Greet Boland, Anthonius S. M. Dofferhoff, Bart van Hoek, Cees van Nieuwkoop, Milan J. Sonneveld, and et al. 2021. "The Netherlands Is on Track to Meet the World Health Organization Hepatitis C Elimination Targets by 2030" Journal of Clinical Medicine 10, no. 19: 4562. https://doi.org/10.3390/jcm10194562