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Impact of SARS-CoV-2 Lockdown on Glycaemic Control: A Retrospective Observational Cohort Study in a Tertiary Setting

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Department of Endocrinology, Diabetes and Metabolism, University Hospital Basel, 4031 Basel, Switzerland
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Institute of Primary Care, University and University Hospital Zurich, 8091 Zurich, Switzerland
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Faculty of Medicine, University of Basel, 4001 Basel, Switzerland
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Department of Information and Communications Technology, University Hospital Basel, 4031 Basel, Switzerland
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Division of Internal Medicine, University Hospital Basel, 4031 Basel, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Didac Mauricio
J. Clin. Med. 2021, 10(18), 4098; https://doi.org/10.3390/jcm10184098
Received: 20 August 2021 / Revised: 3 September 2021 / Accepted: 8 September 2021 / Published: 10 September 2021
(This article belongs to the Section Endocrinology & Metabolism)
We analysed the effects of Swiss national lockdown due to the COVID-19 pandemic on the glycaemic control in patients with diabetes mellitus. In a retrospective observational cohort study with observation period 16 December 2018–27 July 2020, we included tertiary care patients with diabetes and at least one glycated haemoglobin A1c (HbA1c) measurement before and after the lockdown beginning. Main outcome measure was change in HbA1c after the lockdown. We included 1078 patients (86% diabetes type 2) with a mean HbA1c of 55.63 mmol/mol (7.24%). Glycaemic control was susceptible to seasonal changes with higher mean HbA1c in winter as compared to spring (57.49 mmol/mol (7.41%) vs. 55.52 mmol/mol (7.23%), p = 0.013). The lockdown did not affect the mean HbA1c values of all patients. However, we found a higher proportion of type 2 diabetes patients with a worsening HbA1c after the lockdown as compared to the year before (32% vs. 22.9%, p = 0.02). In a mixed-model regression multivariable analysis, inappropriate alcohol intake and hypothyroidism were associated with an increase in HbA1c after the lockdown. In conclusion, the national lockdown had no effect on overall mean HbA1c values but affected a proportion of type 2 diabetes patients with worsening HbA1c, whose individual risk factors were identified. View Full-Text
Keywords: COVID-19; SARS-CoV-2; lockdown; glycaemic control; diabetes mellitus; seasonal variation COVID-19; SARS-CoV-2; lockdown; glycaemic control; diabetes mellitus; seasonal variation
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MDPI and ACS Style

Zechmann, S.; Hotz, L.; Di Gangi, S.; Baumgartl, K.; Plate, A.; Potlukova, E. Impact of SARS-CoV-2 Lockdown on Glycaemic Control: A Retrospective Observational Cohort Study in a Tertiary Setting. J. Clin. Med. 2021, 10, 4098. https://doi.org/10.3390/jcm10184098

AMA Style

Zechmann S, Hotz L, Di Gangi S, Baumgartl K, Plate A, Potlukova E. Impact of SARS-CoV-2 Lockdown on Glycaemic Control: A Retrospective Observational Cohort Study in a Tertiary Setting. Journal of Clinical Medicine. 2021; 10(18):4098. https://doi.org/10.3390/jcm10184098

Chicago/Turabian Style

Zechmann, Stefan, Leana Hotz, Stefania Di Gangi, Klaus Baumgartl, Andreas Plate, and Eliska Potlukova. 2021. "Impact of SARS-CoV-2 Lockdown on Glycaemic Control: A Retrospective Observational Cohort Study in a Tertiary Setting" Journal of Clinical Medicine 10, no. 18: 4098. https://doi.org/10.3390/jcm10184098

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