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The CRBN, CUL4A and DDB1 Expression Predicts the Response to Immunomodulatory Drugs and Survival of Multiple Myeloma Patients

BCMA in Multiple Myeloma—A Promising Key to Therapy

Division of Internal Medicine, University Hospital of Zurich, 8091 Zurich, Switzerland
Faculty of Medicine, University of Basel, 4031 Basel, Switzerland
Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece
Author to whom correspondence should be addressed.
Academic Editor: Krzysztof Giannopoulos
J. Clin. Med. 2021, 10(18), 4088;
Received: 11 August 2021 / Revised: 6 September 2021 / Accepted: 7 September 2021 / Published: 10 September 2021
Despite the discoveries of numerous agents including next generation proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies, multiple myeloma (MM) remains an incurable disease. The field of myeloma treatment in refractory or relapsed patients after standard therapy entered a new era due to the B-cell maturation antigen (BMCA) targeted approach. BCMA is a member of the tumor necrosis factor receptor family with high expression in mature B-lymphocytes and plasma cells. Given the understanding of BCMA mechanism of action in MM, BCMA plays a promising role as a therapeutic target. Several clinical trials are underway to evolve the current BCMA targeted treatment concept such as antibody-drug conjugates (ADCs), bispecific T cell engagers (BITEs) and chimeric antigen receptor (CAR) T cell therapy. Current results of representative BCMA trials may close the gap of the unmet clinical need to further improve the outcome of heavily pretreated MM patients with the potency to change the paradigm in newly diagnosed and refractory MM. This comprehensive review will give an update on various BMCA targeted treatment modalities (ADCs, BITEs, CAR T cell therapy) and its existing results on efficacy and safety from preclinical and clinical trials. View Full-Text
Keywords: BCMA; multiple myeloma; antibody; conjugated; BiTE; ADC; CAR T cell; immunotherapy BCMA; multiple myeloma; antibody; conjugated; BiTE; ADC; CAR T cell; immunotherapy
MDPI and ACS Style

Kleber, M.; Ntanasis-Stathopoulos, I.; Terpos, E. BCMA in Multiple Myeloma—A Promising Key to Therapy. J. Clin. Med. 2021, 10, 4088.

AMA Style

Kleber M, Ntanasis-Stathopoulos I, Terpos E. BCMA in Multiple Myeloma—A Promising Key to Therapy. Journal of Clinical Medicine. 2021; 10(18):4088.

Chicago/Turabian Style

Kleber, Martina, Ioannis Ntanasis-Stathopoulos, and Evangelos Terpos. 2021. "BCMA in Multiple Myeloma—A Promising Key to Therapy" Journal of Clinical Medicine 10, no. 18: 4088.

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