Next Article in Journal
Genetics Variants in the Epoxygenase Pathway of Arachidonic Metabolism Are Associated with Eicosanoids Levels and the Risk of Diabetic Nephropathy
Next Article in Special Issue
Psychometric Validation of the Cardiff Wound Impact Schedule Questionnaire in a Spanish Population with Diabetic Foot Ulcer
Previous Article in Journal
Comparative Analysis of Stress and Deformation between One-Fenced and Three-Fenced Dental Implants Using Finite Element Analysis
Previous Article in Special Issue
The Association between Foot and Ulcer Microcirculation Measured with Laser Speckle Contrast Imaging and Healing of Diabetic Foot Ulcers
Article

Foot Revascularization Avoids Major Amputation in Persons with Diabetes and Ischaemic Foot Ulcers

1
Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy
2
Department of Interventional Radiology, University of Rome “Tor Vergata”, 00133 Rome, Italy
3
Department of Radiology, Casilino Polyclinic, 00169 Rome, Italy
4
Department of Interventional Radiology, Sandro Pertini Hospital, 00157 Rome, Italy
5
Diabetic Foot Centre, Abano Terme Polyclinic, 35031 Abano Terme, Italy
6
Instituto de Investigacion Sanitaria San Carlo Hospital, Complutense University of Madrid, 28040 Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Jin Han
J. Clin. Med. 2021, 10(17), 3977; https://doi.org/10.3390/jcm10173977
Received: 25 July 2021 / Revised: 22 August 2021 / Accepted: 2 September 2021 / Published: 2 September 2021
The study aims to evaluate the effectiveness of foot revascularization in persons with diabetic foot ulcers (DFUs) and below-the-ankle (BTA) arterial disease. Consecutive patients referred for a new active ischaemic DFU requiring lower limb revascularization were considered. Among those, only patients with a BTA arterial disease were included. Revascularization procedures were retrospectively analysed: in the case of successful foot revascularization (recanalization of pedal artery, or plantar arteries or both) or not, patients were respectively divided in two groups, successful foot perfusion (SFP) and failed foot perfusion (FFP). Healing, minor and major amputation at 12 months of follow-up were evaluated and compared. Eighty patients (80) were included. The mean age was 70.5 ± 10.9 years, 55 (68.7%) were male, 72 (90%) were affected by type 2 diabetes with a mean duration of 22.7 ± 11.3 years. Overall 45 (56.2%) patients healed, 47 (58.7%) had minor amputation and 13 (16.2%) major amputation. Outcomes for SFP and FFP were respectively: healing (89.3 vs. 9.1%, p < 0.0001), minor amputation (44.7 vs. 78.8%, p = 0.0001), major amputation (2.1 vs. 36.3%, p < 0.0001). Failed foot revascularization resulted an independent predictor of non-healing, minor amputation, and major amputation. Foot revascularization is mandatory to achieve healing and avoid major amputation in persons with ischaemic DFU and BTA arterial disease. View Full-Text
Keywords: diabetes; diabetic foot ulcer; critical limb ischaemia; revascularization; wound healing diabetes; diabetic foot ulcer; critical limb ischaemia; revascularization; wound healing
Show Figures

Figure 1

MDPI and ACS Style

Meloni, M.; Morosetti, D.; Giurato, L.; Stefanini, M.; Loreni, G.; Doddi, M.; Panunzi, A.; Bellia, A.; Gandini, R.; Brocco, E.; Lazaro-Martinez, J.L.; Lauro, D.; Uccioli, L. Foot Revascularization Avoids Major Amputation in Persons with Diabetes and Ischaemic Foot Ulcers. J. Clin. Med. 2021, 10, 3977. https://doi.org/10.3390/jcm10173977

AMA Style

Meloni M, Morosetti D, Giurato L, Stefanini M, Loreni G, Doddi M, Panunzi A, Bellia A, Gandini R, Brocco E, Lazaro-Martinez JL, Lauro D, Uccioli L. Foot Revascularization Avoids Major Amputation in Persons with Diabetes and Ischaemic Foot Ulcers. Journal of Clinical Medicine. 2021; 10(17):3977. https://doi.org/10.3390/jcm10173977

Chicago/Turabian Style

Meloni, Marco, Daniele Morosetti, Laura Giurato, Matteo Stefanini, Giorgio Loreni, Marco Doddi, Andrea Panunzi, Alfonso Bellia, Roberto Gandini, Enrico Brocco, José L. Lazaro-Martinez, Davide Lauro, and Luigi Uccioli. 2021. "Foot Revascularization Avoids Major Amputation in Persons with Diabetes and Ischaemic Foot Ulcers" Journal of Clinical Medicine 10, no. 17: 3977. https://doi.org/10.3390/jcm10173977

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop