Differences in the Clinical Profile and Management of Atrial Fibrillation According to Gender. Results of the REgistro GallEgo Intercéntrico de Fibrilación Auricular (REGUEIFA) Trial

Cardiology Department, Hospital Universitario Lucus Augusti e Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), 27002 Lugo, Spain

Cardiology Department, Hospital Clínico de Santiago de Compostela, CIBERCV, 15706 A Coruña, Spain

Cardiology Department, Hospital Povisa, 36211 Vigo, Spain

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Cardiology Department, Hospital Arquitecto Marcide, 15405 Ferrol, Spain

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Cardiology Department, Hospital Montecelo, 36162 Pontevedra, Spain

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Cardiology Department, Hospital Álvaro Cunqueiro e Instituto de Investigación Sanitaria Galicia Sur (IISGS), 36312 Vigo, Spain

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Cardiology Department, Complexo Hospitalario Universitario de A Coruña, Instituto de Investigación Biomédica de A Coruña (INIBIC), 15006 A Coruña, Spain

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Cardiology Department, Hospital de Ourense, 32616 Ourense, Spain

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Grupo de Investigación Cardiovascular, Departamento de Ciencias de las Salud e Instituto de Investigación Biomédica de A Coruña (INIBIC), Universidade da Coruña, CIBERCV, 15006 A Coruña, Spain

Author to whom correspondence should be addressed.

Academic Editors: Boyoung Joung and Patrizio Mazzone

J. Clin. Med. 2021, 10(17), 3846; https://doi.org/10.3390/jcm10173846

Received: 27 July 2021 / Revised: 19 August 2021 / Accepted: 26 August 2021 / Published: 27 August 2021

(This article belongs to the Section Cardiology)

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Abstract

To analyze the clinical profile and therapeutic strategy in atrial fibrillation (AF) according to gender in a contemporaneous patient cohort a prospective, multicenter observational study was performed on consecutive patients diagnosed with AF and assessed by cardiology units in the region of Galicia (Spain). A total of 1007 patients were included, of which 32.3% were women. The mean age of the women was significantly greater than that of the men (71.6 versus 65.7 years; p < 0.001), with a higher prevalence of hypertension (HTN) and valve disease. Women more often reported symptoms related to arrhythmia (28.2% in EHRA class I versus 36.4% in men), with a poorer level of symptoms (EHRA classes IIb and III). Thromboembolic risk was significantly higher among women (CHA₂DS₂-VASc 3 ± 1.3 versus 2 ± 1.5), in the same way as bleeding risk (HAS-BLED 0.83 ± 0.78 versus 0.64 ± 0.78) (p < 0.001), and women more often received anticoagulation therapy (94.1% versus 87.6%; p = 0.001). Rhythm control strategies proved significantly less frequent in women (55.8% versus 66.6%; p = 0.001), with a lesser electrical cardioversion (ECV) rate (18.4% versus 27.3%; p = 0.002). Perceived health status was poorer in women. Women were older and presented greater comorbidity than men, with a greater thromboembolic and bleeding risk. Likewise, rhythm control strategies were less frequent than in men, despite the fact that women had poorer perceived quality of life and were more symptomatic. View Full-Text

Keywords: atrial fibrillation; gender; anticoagulation; rhythm control

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MDPI and ACS Style

Durán-Bobín, O.; Elices-Teja, J.; González-Melchor, L.; Vázquez-Caamaño, M.; Fernández-Obanza, E.; González-Babarro, E.; Cabanas-Grandío, P.; Piñeiro-Portela, M.; Prada-Delgado, O.; Gutiérrez-Feijoo, M.; Freire, E.; Díaz-Castro, O.; Muñiz, J.; García-Seara, J.; Gonzalez-Juanatey, C. Differences in the Clinical Profile and Management of Atrial Fibrillation According to Gender. Results of the REgistro GallEgo Intercéntrico de Fibrilación Auricular (REGUEIFA) Trial. J. Clin. Med. 2021, 10, 3846. https://doi.org/10.3390/jcm10173846

AMA Style

Durán-Bobín O, Elices-Teja J, González-Melchor L, Vázquez-Caamaño M, Fernández-Obanza E, González-Babarro E, Cabanas-Grandío P, Piñeiro-Portela M, Prada-Delgado O, Gutiérrez-Feijoo M, Freire E, Díaz-Castro O, Muñiz J, García-Seara J, Gonzalez-Juanatey C. Differences in the Clinical Profile and Management of Atrial Fibrillation According to Gender. Results of the REgistro GallEgo Intercéntrico de Fibrilación Auricular (REGUEIFA) Trial. Journal of Clinical Medicine. 2021; 10(17):3846. https://doi.org/10.3390/jcm10173846

Chicago/Turabian Style

Durán-Bobín, Olga, Juliana Elices-Teja, Laila González-Melchor, María Vázquez-Caamaño, Emiliano Fernández-Obanza, Eva González-Babarro, Pilar Cabanas-Grandío, Miriam Piñeiro-Portela, Oscar Prada-Delgado, Mario Gutiérrez-Feijoo, Evaristo Freire, Oscar Díaz-Castro, Javier Muñiz, Javier García-Seara, and Carlos Gonzalez-Juanatey. 2021. "Differences in the Clinical Profile and Management of Atrial Fibrillation According to Gender. Results of the REgistro GallEgo Intercéntrico de Fibrilación Auricular (REGUEIFA) Trial" Journal of Clinical Medicine 10, no. 17: 3846. https://doi.org/10.3390/jcm10173846

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Differences in the Clinical Profile and Management of Atrial Fibrillation According to Gender. Results of the REgistro GallEgo Intercéntrico de Fibrilación Auricular (REGUEIFA) Trial

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