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Article

Evaluation of Thyroid Hormone Replacement Dosing in Morbidly Obese Hypothyroid Patients after Bariatric Surgery-Induced Weight Loss

1
Grupo Fisiopatoloxía Endocrina, Nutricional e Médica (FENM), Facultad de Ciencias de la Salud, Universidade da Coruña, 15006 A Coruña, Spain
2
Instituto de Investigación Biomedica (INIBIC) and Centro de Investigaciones Científicas Avanzadas (CICA), Universidade da Coruña, 15006 A Coruña, Spain
3
Servicio Endocrinología y Nutrición, Hospital Universitario A Coruña, 15006 A Coruña, Spain
4
Unidad Epidemiologia Clínica y Bioestadística, Hospital Universitario A Coruña, 15006 A Coruña, Spain
5
Servicio Cirugía General y Digestiva, Hospital Universitario A Coruña, 15006 A Coruña, Spain
*
Authors to whom correspondence should be addressed.
Authors contributed equally to this article and share senior authorship.
Academic Editor: Roberta Lupoli
J. Clin. Med. 2021, 10(16), 3685; https://doi.org/10.3390/jcm10163685
Received: 15 July 2021 / Revised: 5 August 2021 / Accepted: 15 August 2021 / Published: 19 August 2021
(This article belongs to the Section Endocrinology & Metabolism)
The most frequent endocrine disease in obese patients is hypothyroidism. To date, there are no clear data regarding what happens to the dose of levothyroxine (LT4) after bariatric surgery (BS). The objective of the present study was to evaluate thyroid hormone replacement dose in morbidly obese hypothyroid patients after BS-induced weight loss. We explore the best type of measured or estimated body weight for LT4 dosing. We performed an observational study evaluating patients with morbid obesity and hypothyroidism who underwent BS. We included 48 patients (three men). In morbidly obese hypothyroid patients 12 months after BS-induced weight loss, the total LT4 dose or the LT4 dose/kg ideal body weight did not change, while there was a significant increase in LT4 dose/body surface area, LT4 dose/kg weight, LT4 dose/kg adjusted body weight, LT4 dose/kg body fat, and LT4 dose/kg lean body weight. There were no differences in LT4 dose and its variation between sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB). The present study strongly suggests that LT4 dosing in obese hypothyroid patients can be individually adapted more precisely if it is based on ideal body weight. View Full-Text
Keywords: obesity; bariatric surgery; hypothyroidism; thyroid hormone replacement obesity; bariatric surgery; hypothyroidism; thyroid hormone replacement
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MDPI and ACS Style

Juiz-Valiña, P.; Cordido, M.; Outeiriño-Blanco, E.; Pértega, S.; Urones, P.; García-Brao, M.J.; Mena, E.; Pena-Bello, L.; Sangiao-Alvarellos, S.; Cordido, F. Evaluation of Thyroid Hormone Replacement Dosing in Morbidly Obese Hypothyroid Patients after Bariatric Surgery-Induced Weight Loss. J. Clin. Med. 2021, 10, 3685. https://doi.org/10.3390/jcm10163685

AMA Style

Juiz-Valiña P, Cordido M, Outeiriño-Blanco E, Pértega S, Urones P, García-Brao MJ, Mena E, Pena-Bello L, Sangiao-Alvarellos S, Cordido F. Evaluation of Thyroid Hormone Replacement Dosing in Morbidly Obese Hypothyroid Patients after Bariatric Surgery-Induced Weight Loss. Journal of Clinical Medicine. 2021; 10(16):3685. https://doi.org/10.3390/jcm10163685

Chicago/Turabian Style

Juiz-Valiña, Paula, María Cordido, Elena Outeiriño-Blanco, Sonia Pértega, Paula Urones, María J. García-Brao, Enrique Mena, Lara Pena-Bello, Susana Sangiao-Alvarellos, and Fernando Cordido. 2021. "Evaluation of Thyroid Hormone Replacement Dosing in Morbidly Obese Hypothyroid Patients after Bariatric Surgery-Induced Weight Loss" Journal of Clinical Medicine 10, no. 16: 3685. https://doi.org/10.3390/jcm10163685

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