Next Article in Journal
Factors of Anti-Vascular Endothelial Growth Factor Therapy Withdrawal in Patients with Neovascular Age-Related Macular Degeneration: Implications for Improving Patient Adherence
Next Article in Special Issue
Prevalence of Chronic Fatigue Syndrome (CFS) in Korea and Japan: A Meta-Analysis
Previous Article in Journal
5-HTT Deficiency in Male Mice Affects Healing and Behavior after Myocardial Infarction
Previous Article in Special Issue
Shadow Burden of Undiagnosed Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) on Society: Retrospective and Prospective—In Light of COVID-19
Due to scheduled maintenance work on our core network, there may be short service disruptions on this website between 16:00 and 16:30 CEST on September 25th.
Article

Evaluating Routine Blood Tests According to Clinical Symptoms and Diagnostic Criteria in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

1
Department of Behavioural Medicine, Faculty of Medicine, University of Oslo, 0315 Oslo, Norway
2
CFS/ME Center, Division of Medicine, Oslo University Hospital, 0318 Oslo, Norway
3
CFS/ME Unit, Division of Rheumatology, Vall d’Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain
4
National Advisory Unit for CFS/ME, Rikshospitalet, Oslo University Hospital, Rikshospitalet OUS, 0372 Oslo, Norway
5
Faculty of Health, VID Specialized University, 0370 Oslo, Norway
*
Author to whom correspondence should be addressed.
Academic Editors: Giovanni Ricevuti and Lorenzo Lorusso
J. Clin. Med. 2021, 10(14), 3105; https://doi.org/10.3390/jcm10143105
Received: 14 April 2021 / Revised: 6 June 2021 / Accepted: 9 July 2021 / Published: 14 July 2021
There is a lack of research regarding blood tests within individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and between patients and healthy controls. We aimed to compare results of routine blood tests between patients and healthy controls. Data from 149 patients diagnosed with ME/CFS based on clinical and psychiatric evaluation as well as on the DePaul Symptom Questionnaire, and data from 264 healthy controls recruited from blood donors were compared. One-way ANCOVA was conducted to examine differences between ME/CFS patients and healthy controls, adjusting for age and gender. Patients had higher sedimentation rate (mean difference: 1.38, 95% CI: 0.045 to 2.714), leukocytes (mean difference: 0.59, 95% CI: 0.248 to 0.932), lymphocytes (mean difference: 0.27, 95% CI: 0.145 to 0.395), neutrophils (mean difference: 0.34, 95% CI: 0.0 89 to 0.591), monocytes (mean difference: 0.34, 95% CI: 0.309 to 0.371), ferritin (mean difference: 28.13, 95% CI: −1.41 to 57.672), vitamin B12 (mean difference: 83.43, 95% CI: 62.89 to 124.211), calcium (mean difference: 0.02, 95% CI: −0.02 to 0.06), alanine transaminase (mean difference: 3.30, 95% CI: −1.37 to -7.971), low-density lipoproteins (mean difference: 0.45, 95% CI: 0.104 to 0.796), and total proteins (mean difference: 1.53, 95% CI: −0.945 to 4.005) than control subjects. The patients had lower potassium levels (mean difference: 0.11, 95% CI: 0.056 to 0.164), creatinine (mean difference: 2.60, 95% CI: 0.126 to 5.074) and creatine kinase (CK) (mean difference: 37.57, 95% CI: −0.282 to 75.422) compared to the healthy controls. Lower CK and creatinine levels may suggest muscle damage and metabolic abnormalities in ME/CFS patients. View Full-Text
Keywords: myalgic encephalomyelitis/chronic fatigue syndrome; routine blood tests; diagnostic criteria; functional status; creatinine; creatine kinase myalgic encephalomyelitis/chronic fatigue syndrome; routine blood tests; diagnostic criteria; functional status; creatinine; creatine kinase
MDPI and ACS Style

Baklund, I.H.; Dammen, T.; Moum, T.Å.; Kristiansen, W.; Duarte, D.S.; Castro-Marrero, J.; Helland, I.B.; Strand, E.B. Evaluating Routine Blood Tests According to Clinical Symptoms and Diagnostic Criteria in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. J. Clin. Med. 2021, 10, 3105. https://doi.org/10.3390/jcm10143105

AMA Style

Baklund IH, Dammen T, Moum TÅ, Kristiansen W, Duarte DS, Castro-Marrero J, Helland IB, Strand EB. Evaluating Routine Blood Tests According to Clinical Symptoms and Diagnostic Criteria in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Journal of Clinical Medicine. 2021; 10(14):3105. https://doi.org/10.3390/jcm10143105

Chicago/Turabian Style

Baklund, Ingrid H., Toril Dammen, Torbjørn Å. Moum, Wenche Kristiansen, Daysi S. Duarte, Jesus Castro-Marrero, Ingrid B. Helland, and Elin B. Strand 2021. "Evaluating Routine Blood Tests According to Clinical Symptoms and Diagnostic Criteria in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome" Journal of Clinical Medicine 10, no. 14: 3105. https://doi.org/10.3390/jcm10143105

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop