Pilot Study of Acupuncture’s Antispasmodic Effect on Upper Gastrointestinal Tract during Endoscopic Submucosal Dissection for Early Gastric Cancer: Controlled Clinical Trial

Suzuki, Masao; Ishizaki, Naoto; Kayo, Takumi; Furuta, Taiga; Igarashi, Ryo; Maki, Takumi; Hoshi, Koki; Yamabe, Akane; Fujisawa, Mariko; Funakubo, Akira; Mitsuma, Tadamichi; Irisawa, Atsushi; Shibukawa, Goro

doi:10.3390/jcm10143050

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Pilot Study of Acupuncture’s Antispasmodic Effect on Upper Gastrointestinal Tract during Endoscopic Submucosal Dissection for Early Gastric Cancer: Controlled Clinical Trial

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Goro Shibukawa

Department of Kampo Medicine, Aizu Medical Center, Fukushima Medical University School of Medicine, Aizuwakamatsu, Fukushima 969-3492, Japan

Course of Acupuncture and Moxibustion, Faculty of Health Sciences, Tsukuba University of Technology, Kasuga, Tsukuba 305-0821, Japan

Department of Gastroenterology, Aizu Medical Center, Fukushima Medical University School of Medicine, Aizuwakamatsu, Fukushima 969-3492, Japan

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Department of Organoid Medicine, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan

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Internal Medicine, Fukushima Prefectural Minamiaizu Hospital, Minamiaizu-gun, Fukushima 967-0006, Japan

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Department of Gastroenterology, Dokkyo Medical University School of Medicine, Shimotsuga, Tochigi 321-0293, Japan

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Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Itabashi, Tokyo 173-8610, Japan

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Academic Editor: Ichiro Yasuda

J. Clin. Med. 2021, 10(14), 3050; https://doi.org/10.3390/jcm10143050

Received: 31 May 2021 / Revised: 2 July 2021 / Accepted: 6 July 2021 / Published: 9 July 2021

(This article belongs to the Special Issue Recent Advances and Future Trends in Digestive Endoscopy)

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Abstract

A prospective study was conducted in patients with early-stage gastric cancer to determine the efficacy and safety of acupuncture stimulation as an antispasmodic compared with conventional medication during the procedure of endoscopic submucosal dissection (ESD) of the upper gastrointestinal tract. This study was a prospective single blinded quasi-randomized controlled trial. Seventy-three patients who were scheduled to undergo ESD for gastric cancer at Aizu Medical Center between 19 February 2016 and 30 June 2016 were assessed for eligibility for the study. Sixty out of 73 patients were included in the study and assigned into two intervention groups: medication group (MG) and acupuncture group (AG). Ease of the procedure was evaluated using modified NIWA classification (MNC) by endoscopist considering the frequency and amplitude of the upper gastrointestinal peristalsis. For the statistical analysis, Mann–Whitney test was used to compare the differences of MNC values (baseline and end of procedure) between two groups. The difference of MNC found in the AG (−2.00 (−3.0 to −2.0)) was significantly greater than that in the MG (−1.00 (−2.0 to −1.0), p < 0.0001, Mann–Whitney test). We consider that acupuncture to the abdomen could be an alternative antispasmodic method during upper gastrointestinal endoscopic procedure. View Full-Text

Keywords: acupuncture; antispasmodic; upper gastrointestinal tract; endoscopic submucosal dissection

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MDPI and ACS Style

Suzuki, M.; Ishizaki, N.; Kayo, T.; Furuta, T.; Igarashi, R.; Maki, T.; Hoshi, K.; Yamabe, A.; Fujisawa, M.; Funakubo, A.; Mitsuma, T.; Irisawa, A.; Shibukawa, G. Pilot Study of Acupuncture’s Antispasmodic Effect on Upper Gastrointestinal Tract during Endoscopic Submucosal Dissection for Early Gastric Cancer: Controlled Clinical Trial. J. Clin. Med. 2021, 10, 3050. https://doi.org/10.3390/jcm10143050

AMA Style

Suzuki M, Ishizaki N, Kayo T, Furuta T, Igarashi R, Maki T, Hoshi K, Yamabe A, Fujisawa M, Funakubo A, Mitsuma T, Irisawa A, Shibukawa G. Pilot Study of Acupuncture’s Antispasmodic Effect on Upper Gastrointestinal Tract during Endoscopic Submucosal Dissection for Early Gastric Cancer: Controlled Clinical Trial. Journal of Clinical Medicine. 2021; 10(14):3050. https://doi.org/10.3390/jcm10143050

Chicago/Turabian Style

Suzuki, Masao, Naoto Ishizaki, Takumi Kayo, Taiga Furuta, Ryo Igarashi, Takumi Maki, Koki Hoshi, Akane Yamabe, Mariko Fujisawa, Akira Funakubo, Tadamichi Mitsuma, Atsushi Irisawa, and Goro Shibukawa. 2021. "Pilot Study of Acupuncture’s Antispasmodic Effect on Upper Gastrointestinal Tract during Endoscopic Submucosal Dissection for Early Gastric Cancer: Controlled Clinical Trial" Journal of Clinical Medicine 10, no. 14: 3050. https://doi.org/10.3390/jcm10143050

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