Next Article in Journal
The Role of Non-Gaussian Models of Diffusion Weighted MRI in Hepatocellular Carcinoma: A Systematic Review
Next Article in Special Issue
Expression Pattern of Leptin and Its Receptors in Endometrioid Endometrial Cancer
Previous Article in Journal
Applications and Limitations of Neuro-Monitoring in Paediatric Anaesthesia and Intravenous Anaesthesia: A Narrative Review
Previous Article in Special Issue
CD133 Expression in the Nucleus Is Associated with Endometrial Carcinoma Staging and Tumor Angioinvasion
Article

The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer

1
Department of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital, 625 00 Brno, Czech Republic
2
Department of Obstetrics and Gynecology, Masaryk University and University Hospital, 625 00 Brno, Czech Republic
3
Department of Laboratory Medicine, Department of Laboratory Methods, Masaryk University and University Hospital, 625 00 Brno, Czech Republic
4
Department of Laboratory Medicine, Masaryk Memorial Cancer Institute, 602 00 Brno, Czech Republic
5
Faculty of Medicine, Institute of Biostatistics and Analyses, Masaryk University, 625 00 Brno, Czech Republic
6
Department of Pathology, Masaryk University and University Hospital, 625 00 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editors: Andrea Romano and Erica Werner
J. Clin. Med. 2021, 10(12), 2640; https://doi.org/10.3390/jcm10122640
Received: 2 May 2021 / Revised: 7 June 2021 / Accepted: 11 June 2021 / Published: 15 June 2021
(This article belongs to the Special Issue Clinical Advances on Endometrial Cancer)
Circulating tumor markers are not routinely used in patients with endometrial cancer (EC). This pilot study evaluated the role of monitoring new biomarkers DJ1 and L1CAM, in correlation with CA125 and HE4, for the effects of anticancer treatment and preoperative management in EC patients. Serial serum levels of DJ1, L1CAM, CA125 and HE4 were collected in 65 enrolled patients. Serum DJ1, L1CAM, CA125 and HE4 levels were significantly higher at the time of diagnosis compared to those measured during follow-up (FU). In patients with recurrent disease, serum DJ1, CA125 and HE4 levels were significantly higher at the time of recurrence compared to levels in disease-free patients. Serum L1CAM levels were also higher in patients with recurrence but without reaching statistical significance. While DJ1 levels were not affected by any of the observed patient-related characteristics, L1CAM levels were significantly higher in patients with age ≥60 years who were overweight. At the time of EC diagnosis, DJ1 and L1CAM serum levels did not correlate with stage, histological type or risk of recurrence. This is a preliminary description of the potential of serial DJ1 and L1CAM serum level measurement for monitoring the effects of treatment in EC patients. View Full-Text
Keywords: tumor markers; endometrial cancer; DJ1; L1CAM tumor markers; endometrial cancer; DJ1; L1CAM
Show Figures

Figure 1

MDPI and ACS Style

Bednarikova, M.; Vinklerova, P.; Gottwaldova, J.; Ovesna, P.; Hausnerova, J.; Minar, L.; Felsinger, M.; Valik, D.; Cermakova, Z.; Weinberger, V. The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer. J. Clin. Med. 2021, 10, 2640. https://doi.org/10.3390/jcm10122640

AMA Style

Bednarikova M, Vinklerova P, Gottwaldova J, Ovesna P, Hausnerova J, Minar L, Felsinger M, Valik D, Cermakova Z, Weinberger V. The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer. Journal of Clinical Medicine. 2021; 10(12):2640. https://doi.org/10.3390/jcm10122640

Chicago/Turabian Style

Bednarikova, Marketa, Petra Vinklerova, Jana Gottwaldova, Petra Ovesna, Jitka Hausnerova, Lubos Minar, Michal Felsinger, Dalibor Valik, Zdenka Cermakova, and Vit Weinberger. 2021. "The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer" Journal of Clinical Medicine 10, no. 12: 2640. https://doi.org/10.3390/jcm10122640

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop