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Article

OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses

1
First Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, Poland
2
Krakow Cardiovascular Research Institute, 30-055 Krakow, Poland
3
Regional Specialist Hospital, Research and Development Center, 51-124 Wroclaw, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Wolfgang Dichtl
J. Clin. Med. 2021, 10(11), 2379; https://doi.org/10.3390/jcm10112379
Received: 5 April 2021 / Revised: 17 May 2021 / Accepted: 21 May 2021 / Published: 28 May 2021
(This article belongs to the Section Cardiology)
Background: optical coherence tomography (OCT) might allow identifying lesion features reportedly associated with plaque vulnerability and increased risk of clinical events. Previous studies on correlation between OCT and functional lesion significance indices reported contradictory results, yet integration of complementary information from both modalities is gaining increased interest. The aim of the study was to compare plaque morphology using OCT in hemodynamically relevant vs. non-relevant lesions by fractional flow reserve (FFR). Methods: consecutive patients with intermediate grade coronary stenoses by angiography were evaluated by both FFR and OCT in this single-center study. Stenoses were labeled hemodynamically relevant in case of the FFR ≤ 0.80. Minimal lumen area (MLA), fibrous cap thickness (FCT), minimal cap thickness over the calcium, angle of the calcium, and necrotic core within the lesions were evaluated. Results: a total of 105 patients (124 vessels) were analyzed. Of them, 65 patients were identified with at least one lesion identified as hemodynamically relevant by FFR (72 vessels, 58.1%). Lesions with FFR ≤0.80 presented with lower mean and minimal lumen area (3.46 ± 1.29 vs. 4.65 ± 2.19, p =0.001 and 1.84 ± 0.97 vs. 2.66 ± 1.40, p = 0.001) compared to patients with FFR > 0.80. No differences were found between groups in the mean and minimal FCT, mean, and maximal necrotic core, calcium angle, as well as the overall rate of calcified and lipid plaques. Conclusion: hemodynamic relevance of intermediate grade lesions correlated moderately with the luminal assessment by OCT. No differences were identified in the plaque morphology between relevant and non-relevant coronary stenoses by FFR. View Full-Text
Keywords: optical coherence tomography; fractional flow reserve; stable coronary artery disease optical coherence tomography; fractional flow reserve; stable coronary artery disease
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MDPI and ACS Style

Tomaniak, M.; Ochijewicz, D.; Kołtowski, Ł.; Rdzanek, A.; Pietrasik, A.; Jąkała, J.; Slezak, M.; Malinowski, K.P.; Zaleska, M.; Maksym, J.; Barus, P.; Roleder, T.; Filipiak, K.J.; Opolski, G.; Kochman, J. OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses. J. Clin. Med. 2021, 10, 2379. https://doi.org/10.3390/jcm10112379

AMA Style

Tomaniak M, Ochijewicz D, Kołtowski Ł, Rdzanek A, Pietrasik A, Jąkała J, Slezak M, Malinowski KP, Zaleska M, Maksym J, Barus P, Roleder T, Filipiak KJ, Opolski G, Kochman J. OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses. Journal of Clinical Medicine. 2021; 10(11):2379. https://doi.org/10.3390/jcm10112379

Chicago/Turabian Style

Tomaniak, Mariusz, Dorota Ochijewicz, Łukasz Kołtowski, Adam Rdzanek, Arkadiusz Pietrasik, Jacek Jąkała, Magdalena Slezak, Krzysztof P. Malinowski, Martyna Zaleska, Jakub Maksym, Piotr Barus, Tomasz Roleder, Krzysztof J. Filipiak, Grzegorz Opolski, and Janusz Kochman. 2021. "OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses" Journal of Clinical Medicine 10, no. 11: 2379. https://doi.org/10.3390/jcm10112379

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