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Acute and Preventive Management of Migraine during Menstruation and Menopause

Neuroscience Section, Department of Applied Clinical Sciences and Biotechnology, University of L’Aquila, 67100 L’Aquila, Italy
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Academic Editor: Antonio Russo
J. Clin. Med. 2021, 10(11), 2263; https://doi.org/10.3390/jcm10112263
Received: 29 April 2021 / Revised: 15 May 2021 / Accepted: 19 May 2021 / Published: 24 May 2021
(This article belongs to the Special Issue Prevention and Acute Treatment of Migraine)
Migraine course is influenced by female reproductive milestones, including menstruation and perimenopause; menstrual migraine (MM) represents a distinct clinical entity. Increased susceptibility to migraine during menstruation and in perimenopause is probably due to fluctuations in estrogen levels. The present review provides suggestions for the treatment of MM and perimenopausal migraine. MM is characterized by long, severe, and poorly treatable headaches, for which the use of long-acting triptans and/or combined treatment with triptans and common analgesics is advisable. Short-term prophylaxis with triptans and/or estrogen treatment is another viable option in women with regular menstrual cycles or treated with combined hormonal contraceptives; conventional prevention may also be considered depending on the attack-related disability and the presence of attacks unrelated to menstruation. In women with perimenopausal migraine, hormonal treatments should aim at avoiding estrogen fluctuations. Future research on migraine treatments will benefit from the ascertainment of the interplay between female sex hormones and the mechanisms of migraine pathogenesis, including the calcitonin gene-related peptide pathway. View Full-Text
Keywords: migraine; menstruation; menopause; migraine treatment; triptans; hormonal treatments migraine; menstruation; menopause; migraine treatment; triptans; hormonal treatments
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MDPI and ACS Style

Ornello, R.; De Matteis, E.; Di Felice, C.; Caponnetto, V.; Pistoia, F.; Sacco, S. Acute and Preventive Management of Migraine during Menstruation and Menopause. J. Clin. Med. 2021, 10, 2263. https://doi.org/10.3390/jcm10112263

AMA Style

Ornello R, De Matteis E, Di Felice C, Caponnetto V, Pistoia F, Sacco S. Acute and Preventive Management of Migraine during Menstruation and Menopause. Journal of Clinical Medicine. 2021; 10(11):2263. https://doi.org/10.3390/jcm10112263

Chicago/Turabian Style

Ornello, Raffaele, Eleonora De Matteis, Chiara Di Felice, Valeria Caponnetto, Francesca Pistoia, and Simona Sacco. 2021. "Acute and Preventive Management of Migraine during Menstruation and Menopause" Journal of Clinical Medicine 10, no. 11: 2263. https://doi.org/10.3390/jcm10112263

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