Urine and Serum Electrolytes and Biochemical Values Associated with Osteoporosis in Premenopausal and Postmenopausal Women: A Longitudinal and Cross-Sectional Study Using Korean Genome and Epidemiology Study (KoGES) Cohort
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Setting and Study Cohort
2.2. Study Groups
2.2.1. Longitudinal Observational Study
2.2.2. Cross-Sectional Study
2.3. Study Outcome
2.4. Data Collection
2.5. Statistical Analyses
3. Results
3.1. Baseline Characteristics of Longitudinal Cohort
3.2. Risk Factors for Osteopenia and Osteoporosis in Pre- and Postmenopausal Participants in the Longitudinal Analysis
3.3. Difference of Serum Calcium, and Urine Uric Acid Levels between Bone Density Groups in Cross-Sectional Cohort
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variables | Premenopausal Women | Postmenopausal Women | |
---|---|---|---|
n = 501 | n = 312 | p-Value | |
Age, years | 43 (41–45) | 55 (52–61) | <0.001 |
Body mass index, kg/m2 | 23.9 (22.2–26.0) | 24.4 (22.6–26.7) | 0.034 |
Waist-hip ratio, cm/cm | 0.83 (0.78–0.89) | 0.89 (0.83–0.94) | <0.001 |
Hypertension, n (%) | 30 (6.0%) | 59 (18.9%) | <0.001 |
Diabetes mellitus, n (%) | 17 (3.4%) | 23 (7.4%) | 0.011 |
Myocardial infarction, n (%) | 3 (0.6%) | 5 (1.6%) | 0.159 |
Alcohol habit, n (%) | 0.016 | ||
Never drinker | 331 (66.1%) | 237 (76.0%) | |
Ex-drinker | 12 (2.4%) | 7 (2.2%) | |
Current drinker | 148 (29.5%) | 65 (20.8%) | |
Smoking habit, n (%) | 0.346 | ||
Never smoker | 468 (93.4%) | 296 (94.9%) | |
Ex-smoker | 3 (0.6%) | 1 (0.3%) | |
Current smoker | 12 (2.4%) | 13 (4.2%) | |
Serum albumin, g/dL | 4.1 (3.9–4.1) | 4.1(3.9–4.1) | 0.506 |
Serum blood urea nitrogen, mg/dL | 12.3 (10.3–14.6) | 13.7 (11.6–16.1) | <0.001 |
Estimated GFR, mL/min/1.73m2 | 104.2 (98.5–105.7) | 93.8 (83.3–97.9) | <0.001 |
Bone density at baseline | |||
distal radius T-score | 1.2 (0.4–2.1) | 0.5 (−0.1 to 1.25) | <0.001 |
distal radius Z-score | 1.3 (0.5–2.1) | 1.7 (1.0–2.6) | <0.001 |
midshaft tibia T-score | 0.1 (−0.3–1.1) | 0 (−0.6–0.6) | <0.001 |
midshaft tibia Z-score | 0.3 (−0.2–1.2) | 1.0 (0.4–1.7) | <0.001 |
Serum and Urine electrolytes | |||
Serum calcium (albumin corrected), mg/dL | 9.5 (9.3–9.7) | 9.7 (9.5–9.9) | <0.001 |
Serum sodium, mmol/L | 142 (140–143) | 143 (141–144) | <0.001 |
Urine calcium/creatinine, mg/mg | 0.12 (0.08–0.17) | 0.14 (0.09–0.20) | <0.001 |
Urine sodium/creatinine, mmol/mg | 1.51 (1.08–2.16) | 1.93 (1.30–2.60) | <0.001 |
Urine uric acid/creatinine, mg/mg | 0.48 (0.40–0.58) | 0.52 (0.43–0.62) | <0.001 |
Urine protein/creatinine, mg/mg | 0.06 (0.04–0.11) | 0.08 (0.05–0.14) | <0.001 |
Variables | Osteopenia (Compared to Normal Bone Density) | Osteoporosis (Compared to Normal Bone Density) | ||
---|---|---|---|---|
RRR (95% CI) | p-Value | RRR (95% CI) | p-Value | |
In premenopausal women * | ||||
Age, years | 1.13 (1.06–1.21) | <0.001 | 1.15 (1.04–1.28) | 0.001 |
Baseline T-score | 0.38 (0.27–0.53) | <0.001 | 0.12 (0.03–0.44) | 0.009 |
Serum calcium, mg/dL | 0.90 (0.46–1.75) | 0.752 | 4.03 (1.09–14.93) | 0.037 |
In postmenopausal women ** | ||||
Age, years | 1.03 (0.99–1.08) | 0.169 | 1.07 (1.00–1.14) | 0.043 |
Baseline T-score | 0.33 (0.21–0.52) | <0.001 | 0.19 (0.09–0.40) | <0.001 |
Hypertension | 2.30 (1.02–5.19) | 0.044 | 3.83 (1.43–10.25) | 0.008 |
Urine uric acid/creatinine, mg/mg | 2.47 (0.38–16.20) | 0.345 | 24.08 (1.79–323.69) | 0.016 |
Serum calcium, mg/dL | 3.33 (1.34–8.32) | 0.01 | 1.77 (0.48–6.59) | 0.395 |
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Park, H.-S.; Kim, G.-Y.; Lo, J.-A.; Kim, J.-S.; Ahn, S.-Y.; Ko, G.-J.; Kwon, Y.-J.; Kim, J.-E. Urine and Serum Electrolytes and Biochemical Values Associated with Osteoporosis in Premenopausal and Postmenopausal Women: A Longitudinal and Cross-Sectional Study Using Korean Genome and Epidemiology Study (KoGES) Cohort. J. Clin. Med. 2021, 10, 2155. https://doi.org/10.3390/jcm10102155
Park H-S, Kim G-Y, Lo J-A, Kim J-S, Ahn S-Y, Ko G-J, Kwon Y-J, Kim J-E. Urine and Serum Electrolytes and Biochemical Values Associated with Osteoporosis in Premenopausal and Postmenopausal Women: A Longitudinal and Cross-Sectional Study Using Korean Genome and Epidemiology Study (KoGES) Cohort. Journal of Clinical Medicine. 2021; 10(10):2155. https://doi.org/10.3390/jcm10102155
Chicago/Turabian StylePark, Hae-Sang, Ga-Young Kim, Jong-Ah Lo, Jin-Sun Kim, Shin-Young Ahn, Gang-Jee Ko, Young-Joo Kwon, and Ji-Eun Kim. 2021. "Urine and Serum Electrolytes and Biochemical Values Associated with Osteoporosis in Premenopausal and Postmenopausal Women: A Longitudinal and Cross-Sectional Study Using Korean Genome and Epidemiology Study (KoGES) Cohort" Journal of Clinical Medicine 10, no. 10: 2155. https://doi.org/10.3390/jcm10102155