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Article

Adherence to Prescribed Acamprosate in Alcohol Dependence and 1-Year Morbidities and Mortality: Utilizing a Data Linkage Methodology

1
Department of Psychology, National University of Singapore, Singapore 117572, Singapore
2
Division of Population and Behavioural Sciences, St Andrews University Medical School, St Andrews KY16 9TF, UK
*
Authors to whom correspondence should be addressed.
Academic Editor: Anna Klimkiewicz
J. Clin. Med. 2021, 10(10), 2102; https://doi.org/10.3390/jcm10102102
Received: 30 March 2021 / Revised: 7 May 2021 / Accepted: 10 May 2021 / Published: 13 May 2021
(This article belongs to the Special Issue Clinical Management of Substance Use Disorders: Future Trends)
Objectives: We tested the hypothesis that poor adherence is associated with a greater risk of alcohol-caused mortality and morbidities within the first year of discontinuing this medication. Materials and Methods: A retrospective cohort study of 3319 individuals who received acamprosate in the East of Scotland in a 10-year period was conducted using a health informatics approach with record linkage of dispensing data, hospital utilization (SMR) and General Register Office of Scotland (GROS) data. The primary outcome was adherence between one to six months after initiating acamprosate medication. The secondary outcome was all-cause morbidities and mortality. Results: Of the total 3319 individuals identified, a good adherence index of >80% was found in 59% of those prescribed acamprosate after three months and 6% after six months. There were significant linear trends of poorer adherence with increased risk of alcohol-caused mortality (Hazard Ratio, HR 1.2), medical morbidities especially neoplasm (HR 4.1) and poisoning (HR 1.4), and psychiatric morbidities especially stress (HR 35.1), psychotic (HR 5.6) and neurotic disorders, and directly alcohol induced conditions (7.4 HR) after adjustment for other factors within a one-year period of initiation of acamprosate treatment. Discussion and Conclusions: Further exploratory studies using this digitalized approach should be encouraged in order to capture role of compliance to acamprosate and other types of medication that are known to reduce relapse into alcohol dependence and its direct relationship to mortality and morbidities in this population. View Full-Text
Keywords: adherence; alcohol; acamprosate; mortality; morbidities; data linkage adherence; alcohol; acamprosate; mortality; morbidities; data linkage
MDPI and ACS Style

Tolomeo, S.; Baldacchino, A. Adherence to Prescribed Acamprosate in Alcohol Dependence and 1-Year Morbidities and Mortality: Utilizing a Data Linkage Methodology. J. Clin. Med. 2021, 10, 2102. https://doi.org/10.3390/jcm10102102

AMA Style

Tolomeo S, Baldacchino A. Adherence to Prescribed Acamprosate in Alcohol Dependence and 1-Year Morbidities and Mortality: Utilizing a Data Linkage Methodology. Journal of Clinical Medicine. 2021; 10(10):2102. https://doi.org/10.3390/jcm10102102

Chicago/Turabian Style

Tolomeo, Serenella, and Alex Baldacchino. 2021. "Adherence to Prescribed Acamprosate in Alcohol Dependence and 1-Year Morbidities and Mortality: Utilizing a Data Linkage Methodology" Journal of Clinical Medicine 10, no. 10: 2102. https://doi.org/10.3390/jcm10102102

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