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Membranes 2018, 8(3), 62; https://doi.org/10.3390/membranes8030062

A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering

1
Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Korea
2
Department of Chemistry, Amrit Campus, Tribhuvan University, Kathmandu 44613, Nepal
3
Division of Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Korea
*
Authors to whom correspondence should be addressed.
Received: 29 June 2018 / Revised: 27 July 2018 / Accepted: 9 August 2018 / Published: 14 August 2018
(This article belongs to the Special Issue Electrospun Nanofiber Membranes: Advances and Applications)
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Abstract

Bone tissue engineering is an interdisciplinary field where the principles of engineering are applied on bone-related biochemical reactions. Scaffolds, cells, growth factors, and their interrelation in microenvironment are the major concerns in bone tissue engineering. Among many alternatives, electrospinning is a promising and versatile technique that is used to fabricate polymer fibrous scaffolds for bone tissue engineering applications. Copolymerization and polymer blending is a promising strategic way in purpose of getting synergistic and additive effect achieved from either polymer. In this review, we summarize the basic chemistry of bone, principle of electrospinning, and polymers that are used in bone tissue engineering. Particular attention will be given on biomechanical properties and biological activities of these electrospun fibers. This review will cover the fundamental basis of cell adhesion, differentiation, and proliferation of the electrospun fibers in bone tissue scaffolds. In the last section, we offer the current development and future perspectives on the use of electrospun mats in bone tissue engineering. View Full-Text
Keywords: bone tissue regeneration; electrospinning; biocompatible polymers; nanotechnology; biomimicry bone tissue regeneration; electrospinning; biocompatible polymers; nanotechnology; biomimicry
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Bhattarai, D.P.; Aguilar, L.E.; Park, C.H.; Kim, C.S. A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering. Membranes 2018, 8, 62.

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