Next Article in Journal
Theoretical Evaluation of Polyelectrolyte Layering during Layer-by-Layer Coating of Ultrafiltration Hollow Fiber Membranes
Next Article in Special Issue
Comparison between Lipase Performance Distributed at the O/W Interface by Membrane Emulsification and by Mechanical Stirring
Previous Article in Journal
Removal of Sulfadiazine by Polyamide Nanofiltration Membranes: Measurement, Modeling, and Mechanisms
Article

Block Copolymer-Based Magnetic Mixed Matrix Membranes—Effect of Magnetic Field on Protein Permeation and Membrane Fouling

1
Advanced Membranes and Porous Materials Center (AMPM), Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), 23955-6900 Thuwal, Saudi Arabia
2
Institut Européen des Membranes, IEM UMR 5635, Univ Montpellier, ENSCM, CNRS, 34070 Montpellier, France
3
Laboratorio de Microscopías Avanzadas (LMA), Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, 50018 Zaragoza, Spain
4
Networking Research Centre on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, 28029 Madrid, Spain
5
Instituto de Nanociencia y Materiales de Aragoń (INMA), CSIC-Universidad de Zaragoza, 50009 Zaragoza, Spain
6
LAQV-REQUIMTE, Departamento de Química, Campus de Caparica, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal
*
Authors to whom correspondence should be addressed.
Academic Editors: Simona Salerno, Enrico Drioli and Loredana De Bartolo
Membranes 2021, 11(2), 105; https://doi.org/10.3390/membranes11020105
Received: 30 December 2020 / Revised: 27 January 2021 / Accepted: 28 January 2021 / Published: 2 February 2021
(This article belongs to the Special Issue Membrane and Membrane Bioreactors Applied to Health and Life Sciences)
In this study, we report the impact of the magnetic field on protein permeability through magnetic-responsive, block copolymer, nanocomposite membranes with hydrophilic and hydrophobic characters. The hydrophilic nanocomposite membranes were composed of spherical polymeric nanoparticles (NPs) synthesized through polymerization-induced self-assembly (PISA) with iron oxide NPs coated with quaternized poly(2-dimethylamino)ethyl methacrylate. The hydrophobic nanocomposite membranes were prepared via nonsolvent-induced phase separation (NIPS) containing poly (methacrylic acid) and meso-2,3-dimercaptosuccinic acid-coated superparamagnetic nanoparticles (SPNPs). The permeation experiments were carried out using bovine serum albumin (BSA) as the model solute, in the absence of the magnetic field and under permanent and cyclic magnetic field conditions OFF/ON (strategy 1) and ON/OFF (strategy 2). It was observed that the magnetic field led to a lower reduction in the permeate fluxes of magnetic-responsive membranes during BSA permeation, regardless of the magnetic field strategy used, than that obtained in the absence of the magnetic field. Nevertheless, a comparative analysis of the effect caused by the two cyclic magnetic field strategies showed that strategy 2 allowed for a lower reduction of the original permeate fluxes during BSA permeation and higher protein sieving coefficients. Overall, these novel magneto-responsive block copolymer nanocomposite membranes proved to be competent in mitigating biofouling phenomena in bioseparation processes. View Full-Text
Keywords: block copolymers; magneto-responsive membranes; superparamagnetic nanoparticles; protein filtration block copolymers; magneto-responsive membranes; superparamagnetic nanoparticles; protein filtration
Show Figures

Graphical abstract

MDPI and ACS Style

Upadhyaya, L.; Semsarilar, M.; Quemener, D.; Fernández-Pacheco, R.; Martinez, G.; Coelhoso, I.M.; Nunes, S.P.; Crespo, J.G.; Mallada, R.; Portugal, C.A.M. Block Copolymer-Based Magnetic Mixed Matrix Membranes—Effect of Magnetic Field on Protein Permeation and Membrane Fouling. Membranes 2021, 11, 105. https://doi.org/10.3390/membranes11020105

AMA Style

Upadhyaya L, Semsarilar M, Quemener D, Fernández-Pacheco R, Martinez G, Coelhoso IM, Nunes SP, Crespo JG, Mallada R, Portugal CAM. Block Copolymer-Based Magnetic Mixed Matrix Membranes—Effect of Magnetic Field on Protein Permeation and Membrane Fouling. Membranes. 2021; 11(2):105. https://doi.org/10.3390/membranes11020105

Chicago/Turabian Style

Upadhyaya, Lakshmeesha, Mona Semsarilar, Damien Quemener, Rodrigo Fernández-Pacheco, Gema Martinez, Isabel M. Coelhoso, Suzana P. Nunes, João G. Crespo, Reyes Mallada, and Carla A.M. Portugal. 2021. "Block Copolymer-Based Magnetic Mixed Matrix Membranes—Effect of Magnetic Field on Protein Permeation and Membrane Fouling" Membranes 11, no. 2: 105. https://doi.org/10.3390/membranes11020105

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop