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Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases

by 1,2,†, 1,2,†, 1,2 and 1,2,*
1
Izmir Biomedicine and Genome Center (IBG), Dokuz Eylul University Health Campus, Inciralti-Balcova, Izmir 35340, Turkey
2
Izmir International Biomedicine and Genome Institute (IBG-Izmir), Dokuz Eylul University, Inciralti-Balcova, Izmir 35340, Turkey
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Agnieszka Polit and Paweł Mystek
Membranes 2021, 11(11), 844; https://doi.org/10.3390/membranes11110844
Received: 24 September 2021 / Revised: 23 October 2021 / Accepted: 27 October 2021 / Published: 29 October 2021
(This article belongs to the Special Issue Membrane Domains Organization and Interactions)
Wnt signaling pathways constitute a group of signal transduction pathways that direct many physiological processes, such as development, growth, and differentiation. Dysregulation of these pathways is thus associated with many pathological processes, including neurodegenerative diseases, metabolic disorders, and cancer. At the same time, alterations are observed in plasma membrane compositions, lipid organizations, and ordered membrane domains in brain and metabolic diseases that are associated with Wnt signaling pathway activation. Here, we discuss the relationships between plasma membrane components—specifically ligands, (co) receptors, and extracellular or membrane-associated modulators—to activate Wnt pathways in several brain and metabolic diseases. Thus, the Wnt–receptor complex can be targeted based on the composition and organization of the plasma membrane, in order to develop effective targeted therapy drugs. View Full-Text
Keywords: Wnt signaling pathway; plasma membrane; ordered domain; lipid raft; Alzheimer’s disease; Parkinson’s disease; Schizophrenia; diabetes; obesity; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis Wnt signaling pathway; plasma membrane; ordered domain; lipid raft; Alzheimer’s disease; Parkinson’s disease; Schizophrenia; diabetes; obesity; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis
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MDPI and ACS Style

Karabicici, M.; Azbazdar, Y.; Iscan, E.; Ozhan, G. Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases. Membranes 2021, 11, 844. https://doi.org/10.3390/membranes11110844

AMA Style

Karabicici M, Azbazdar Y, Iscan E, Ozhan G. Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases. Membranes. 2021; 11(11):844. https://doi.org/10.3390/membranes11110844

Chicago/Turabian Style

Karabicici, Mustafa, Yagmur Azbazdar, Evin Iscan, and Gunes Ozhan. 2021. "Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases" Membranes 11, no. 11: 844. https://doi.org/10.3390/membranes11110844

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