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Article

In Vivo Comparative Evaluation of Biocompatibility and Biodegradation of Bovine and Porcine Collagen Membranes

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Graduate Program, Dentistry School, Universidade Federal Fluminense, Niteroi 24020-140, RJ, Brazil
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Oral Surgery Department, Dentistry School, Universidade Veiga de Almeida, Rio de Janeiro 20271-020, RJ, Brazil
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Oral Surgery Department, Dentistry School, Universidade Iguaçu, Nova Iguaçu 26260-045, RJ, Brazil
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Clinical Research Laboratory in Dentistry, Universidade Federal Fluminense, Niteroi 24020-140, RJ, Brazil
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Post-Graduation Program in Dentistry, Universidade Veiga de Almeida, Rio de Janeiro 20271-020, RJ, Brazil
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Oral Surgery Department, Universidade Federal Fluminense, Niteroi 24020-140, RJ, Brazil
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Oral Diagnosis Department, Universidade Federal Fluminense, Niteroi 24020-140, RJ, Brazil
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Post-Graduation Program in Biotechnology, Universidade Federal Fluminense, Niteroi 24020-140, RJ, Brazil
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Orthodontics Department, Universidade Federal Fluminense, Niteroi 24020-140, RJ, Brazil
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Private Practice, 24128 Bergamo, Italy
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Periodontics Department, Universidade Federal Fluminense, Niteroi 24020-140, RJ, Brazil
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Author to whom correspondence should be addressed.
Membranes 2020, 10(12), 423; https://doi.org/10.3390/membranes10120423
Received: 19 November 2020 / Revised: 7 December 2020 / Accepted: 8 December 2020 / Published: 15 December 2020
(This article belongs to the Special Issue Biocompatible Membranes)
Mechanical barriers prevent the invasion of the surrounding soft tissues within the bone defects. This concept is known as Guided Bone Regeneration (GBR). The knowledge about the local tissue reaction and the time of degradation of absorbable membranes favors the correct clinical indication. This study aimed to evaluate the biocompatibility and biodegradation of a bovine collagen membrane (Lyostypt®, São Gonçalo, Brazil) and compare it to a porcine collagen membrane (Bio-Gide®) implanted in the subcutaneous tissue of mice, following ISO 10993-6:2016. Thirty Balb-C mice were randomly divided into three experimental groups, LT (Lyostypt®), BG (Bio-Gide®), and Sham (without implantation), and subdivided according to the experimental periods (7, 21, and 63 days). The BG was considered non-irritant at seven days and slight and moderate irritant at 21 and 63 days, respectively. The LT presented a small irritant reaction at seven days, a mild reaction after 21, and a reduction in the inflammatory response at 63 days. The biodegradation of the LT occurred more rapidly compared to the BG after 63 days. This study concluded that both membranes were considered biocompatible since their tissue reactions were compatible with the physiological inflammatory process; however, the Bio-Gide® was less degraded during the experimental periods, favoring the guided bone regeneration process. View Full-Text
Keywords: biocompatibility; biodegradation; collagen membrane; guided bone regeneration; subcutaneous; mice biocompatibility; biodegradation; collagen membrane; guided bone regeneration; subcutaneous; mice
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MDPI and ACS Style

Neto, A.M.D.; Sartoretto, S.C.; Duarte, I.M.; Resende, R.F.d.B.; Neves Novellino Alves, A.T.; Mourão, C.F.d.A.B.; Calasans-Maia, J.; Montemezzi, P.; Tristão, G.C.; Calasans-Maia, M.D. In Vivo Comparative Evaluation of Biocompatibility and Biodegradation of Bovine and Porcine Collagen Membranes. Membranes 2020, 10, 423. https://doi.org/10.3390/membranes10120423

AMA Style

Neto AMD, Sartoretto SC, Duarte IM, Resende RFdB, Neves Novellino Alves AT, Mourão CFdAB, Calasans-Maia J, Montemezzi P, Tristão GC, Calasans-Maia MD. In Vivo Comparative Evaluation of Biocompatibility and Biodegradation of Bovine and Porcine Collagen Membranes. Membranes. 2020; 10(12):423. https://doi.org/10.3390/membranes10120423

Chicago/Turabian Style

Neto, Abdu M.D., Suelen C. Sartoretto, Isabelle M. Duarte, Rodrigo F.d.B. Resende, Adriana T. Neves Novellino Alves, Carlos F.d.A.B. Mourão, Jose Calasans-Maia, Pietro Montemezzi, Gilson C. Tristão, and Mônica D. Calasans-Maia 2020. "In Vivo Comparative Evaluation of Biocompatibility and Biodegradation of Bovine and Porcine Collagen Membranes" Membranes 10, no. 12: 423. https://doi.org/10.3390/membranes10120423

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