A Long-Term Observation on the Possible Adverse Effects in Japanese Adolescent Girls after Human Papillomavirus Vaccination
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Walboomers, J.M.; Jacobs, M.V.; Manos, M.M.; Bosch, F.X.; Kummer, J.A.; Shah, K.V.; Snijders, P.J.; Peto, J.; Meijer, C.J.; Muñoz, N. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J. Pathol. 1999, 189, 12–19. [Google Scholar] [CrossRef]
- FUTURE II Study Group. Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions. N. Engl. J. Med. 2007, 356, 1915–1917. [Google Scholar] [CrossRef] [PubMed]
- Jeurissen, S.; Makar, A. Epidemiological and economic impact of human papillomavirus vaccines. Int. J. Gynecol. Cancer 2009, 19, 761–771. [Google Scholar] [CrossRef] [PubMed]
- The Ministry of Health, Labour and Welfare. Available online: http://www.mhlw.go.jp/bunya/kenkou/kekkaku-kansenshou28/pdf/kankoku_h25_6_01.pdf (accessed on 8 June 2021). (In Japanese)
- Kinoshita, T.; Abe, R.; Hineno, A.; Tsunekawa, K.; Nakane, S.; Ikeda, S. Peripheral sympathetic nerve dysfunction in adolescent Japanese girls following immunization with the human papillomavirus vaccine. Intern. Med. 2014, 53, 2185–2200. [Google Scholar] [CrossRef] [Green Version]
- Ozawa, K.; Hineno, A.; Kinoshita, T.; Ishihara, S.; Ikeda, S. Suspected adverse effects after human papillomavirus vaccination: A temporal relationship between vaccine administration and the appearance of symptoms in Japan. Drug Saf. 2017, 40, 1219–1229. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Martínez-Lavín, M.; Amezcua-Guerra, L. Serious adverse events after HPV vaccination: A critical review of randomized trials and post-marketing case series. Clin. Rheumatol. 2017, 36, 2169–2178. [Google Scholar] [CrossRef] [PubMed]
- Blitshetyn, S.; Brinth, L.; Hendrickson, J.E.; Martínez-Lavín, M. Autonomic dysfunction and HPV immunization: An overview. Immunol. Res. 2018, 66, 744–754. [Google Scholar] [CrossRef]
- Hirai, T.; Kuroiwa, Y.; Hayashi, T.; Uchiyama, M.; Nakamura, I.; Yokota, S.; Nakajima, T.; Nishioka, K.; Iguchi, Y. Adverse effects of human papillomavirus virus vaccination on central nervous system: Neuro-endocrinological disorders of hypothalamo-pituitary axis. Auton. Nerv. Syst. 2016, 53, 49–64. [Google Scholar] [CrossRef]
- Larson, H. The world must accept that HPV vaccine is safe. Nature 2015, 528, 9. [Google Scholar] [CrossRef] [Green Version]
- Hviid, A.; Svanström, H.; Schekker, N.M.; Grönlund, O.; Pasternak, B.; Arnheim-Dahlström, L. Human papillomavirus vaccination of adult women and risk of autoimmune and neurological diseases. J. Intern. Med. 2017, 283, 154–165. [Google Scholar] [CrossRef] [Green Version]
- Phillips, A.; Patel, C.; Pillsbury, A.; Brotherton, J.; Macartney, K. Safety of human papillomavirus vaccines: An updated review. Drug Saf. 2018, 41, 329–346. [Google Scholar] [CrossRef]
- Phillips, A.; Hickie, M.; Totterdell, J.; Brotherton, J.; Dey, A.; Hill, R.; Snelling, T.; Macartney, K. Adverse events following HPV vaccination: 11 years of surveillance in Australia. Vaccine 2020, 38, 6038–6046. [Google Scholar] [CrossRef]
- Blitshteyn, S. Postural tachycardia syndrome following human papillomavirus vaccination. Eur. J. Neurol. 2014, 21, 135–139. [Google Scholar] [CrossRef]
- Brinth, L.; Theibel, A.C.; Pors, K.; Mehlsen, J. Suspected side effects to the quadrivalent human papillomavirus vaccine. Dan. Med. J. 2015, 62, A5064. [Google Scholar] [PubMed]
- Brinth, L.S.; Pors, K.; Theibel, A.C.; Mehlsen, J. Orthostatic intolerance and postural tachycardia syndrome as suspected adverse effects of vaccination against human papillomavirus. Vaccine 2015, 33, 2602–2605. [Google Scholar] [CrossRef]
- Palmieri, B.; Poddighe, D.; Vadalà, M.; Laurino, C.; Carnovale, C.; Clementi, E. Severe somatoform and dysautonomic syndromes after HPV vaccination: Case series and review of literature. Immunol. Res. 2017, 65, 106–116. [Google Scholar] [CrossRef] [Green Version]
- Martínez-Lavín, M. Fibromyalgia-like illness in 2 girls after human papillomavirus vaccination. J. Clin. Rheumatol. 2014, 20, 392–393. [Google Scholar] [CrossRef] [PubMed]
- Martinez, P. Motor and Sensory Clinical Findings in Girls Vaccinated against the Human Papillomavirus from Carmen de Bolivar, Colombia. Available online: https://pompiliomartinez.wordpress.com/2016/03/04/motor-and-sensory-clinical-findings-in-girls-vaccinated-against-the-human-papillomavirus-from-carmen-de-bolivar-colombia/ (accessed on 8 June 2021).
- Chandler, R.E. Safety concerns with HPV vaccines continue to linger: Are current vaccine pharmacovigilance practices sufficient? Drug Saf. 2017, 40, 1167–1170. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- The Ministry of Health, Labour and Welfare. Available online: http://www.mhlw.go.jp/file/05-Shingikai-10601000-Daijinkanboukouseikagakuka-Kouseikagakuka/0000161349.pdf (accessed on 8 June 2021). (In Japanese)
- The Ministry of Health, Labour and Welfare. Available online: http://www.mhlw.go.jp/file/05-Shingikai-10601000-Daijinkanboukouseikagakuka-Kouseikagakuka/0000161329.pdf (accessed on 8 June 2021). (In Japanese)
- Matsudaira, T.; Takahashi, Y.; Matsuda, K.; Ikeda, H.; Usui, K.; Obi, T.; Inoue, Y. Cognitive dysfunction and regional cerebral blood flow changes in Japanese females after human papillomavirus vaccination. Neurol. Clin. Neurosci. 2016, 4, 220–227. [Google Scholar] [CrossRef]
- Stewart, J.M. Autonomic nervous system dysfunction in adolescents with postural orthostatic tachycardia syndrome and chronic fatigue syndrome is characterized by attenuated vagal baroreflex and potentiated sympathetic vasomotion. Pediatr. Res. 2000, 48, 218–226. [Google Scholar] [CrossRef] [Green Version]
- Karas, B.; Grubb, B.P.; Boeth, K.; Kip, K. The postural orthostatic tachycardia syndrome: A potentially treatable cause of chronic fatigue, exercise intolerance, and cognitive impairment in adolescents. Pacing Clin. Electrophysiol. 2000, 23, 344–351. [Google Scholar] [CrossRef] [PubMed]
- Halicka, M.; Vittersø, A.D.; Proulx, M.J.; Bultitude, J.H. Neuropsychological changes in complex regional pain syndrome (CRPS). Behav. Neurol. 2020, 2020, 4561831. [Google Scholar] [CrossRef]
- Ocon, A.J. Caught in the thickness of brain fog: Exploring the cognitive symptoms of chronic fatigue syndrome. Front. Physiol. 2013, 4, 63. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Meyer, C.; Heidecke, H. Antibodies against GPCR. Front Biosci. 2018, 23, 2177–2194. [Google Scholar]
- Yub, X.; Stavrakis, S.; Hill, M.A.; Huang, S.; Reim, S.; Lin, H.; Khan, M.; Hamlett, S.; Cunningham, M.W.; Kem, D.C. Autoantibody activation of beta-adrenergic and muscarinic receptors contributes to an “autoimmune” orthostatic hypotension. J. Am. Soc. Hypertens. 2012, 6, 40–47. [Google Scholar] [CrossRef] [Green Version]
- Ruzieh, M.; Batizy, L.; Dasa, O.; Oostra, C.; Grubb, B. The role of autoantibodies in the syndromes of orthostatic intolerance: A systemic review. Scand. Cardiovasc. J. 2017, 51, 243–247. [Google Scholar] [CrossRef] [PubMed]
- Kohr, D.; Singh, P.; Tschernatsch, M.; Kaps, M.; Pouokam, E.; Diener, M.; Kummer, W.; Birklein, F.; Vincent, A.; Goebel, A.; et al. Autoimmunity against the β2 adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome. Pain 2011, 152, 2690–2700. [Google Scholar] [CrossRef]
- Dubuis, E.; Thompson, V.; Leite, M.I.; Blaes, F.; Maihofner, C.; Greensmith, D.; Vincent, A.; Shenker, N.; Kuttikat, A.; Leuwer, M.; et al. Longstanding complex regional pain syndrome is associated with activating autoantibodies against alpha-1a adrenoreceptors. Pain 2014, 155, 2408–2417. [Google Scholar] [CrossRef]
- Loebel, M.; Grabowski, P.; Heidecke, H.; Bauer, S.; Hanitsch, L.G.; Wittke, K.; Meisel, C.; Reinke, P.; Volk, H.D.; Fluge, Ø.; et al. Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with chronic fatigue syndrome. Brain Behav. Immun. 2016, 52, 32–39. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Hendrickson, J.E.; Hendrickson, E.T.; Gehrie, E.A.; Sidhe, D.; Wallukat, G.; Schimke, I.; Tormey, C.A. Complex regional pain syndrome and dysautonomia in a 14-year-old girl responsive to therapeutic plasma exchange. J. Clin. Apher. 2016, 31, 368–374. [Google Scholar] [CrossRef] [Green Version]
- Hendrickson, J.E.; Tormey, C.A. Human papilloma virus vaccination and dysautonomia: Consideration for autoantibody evaluation and HLA typing. Vaccine 2016, 34, 4468. [Google Scholar] [CrossRef]
- Blitshteyn, S.; Brook, J. Postural tachycardia syndrome (POTS) with anti-NMDA receptor antibodies after human papillomavirus vaccination. Immunol. Res. 2017, 65, 282–284. [Google Scholar] [CrossRef] [PubMed]
- Schofield, J.R.; Hendrickson, J.E. Autoimmunity, autonomic neuropathy, and the HPV vaccination: A vulnerable subpopulation. Clin. Pediatr. 2018, 57, 603–606. [Google Scholar] [CrossRef] [PubMed]
- Hineno, A.; Ikeda, S.; Scheibenbogen, C.; Heidecke, H.; Schulze-Forster, K.; Junker, J.; Riemekasten, G.; Dechend, R.; Dragun, D.; Shoenfeld, Y. Autoantibodies against autonomic nerve receptors in adolescent Japanese girls after immunization with human papillomavirus vaccine. Ann. Arthritis Clin. Rheumatol. 2019, 2, 1014. [Google Scholar]
- Simms, K.T.; Hanley, S.J.B.; Smith, M.A.; Keane, A.; Canfell, K. Impact of HPV vaccine hesitancy on cervical cancer in Japan: A modelling study. Lancet Public Health 2020, 5, e223–e234. [Google Scholar] [CrossRef]
- Cervantes, J.L.; Doan, A.H. Discrepancies in the evaluation of the safety of the human papillomavirus vaccine. Mem. Inst. Oswaldo Cruz 2018, 113, e180063. [Google Scholar] [CrossRef] [PubMed]
- Chambuso, R.S.; Rebello, G.; Kaambo, E. Personalized human papillomavirus vaccination for persistence of immunity for cervical cancer prevention: A critical review with experts’ opinions. Front. Oncol. 2020, 10, 548. [Google Scholar] [CrossRef] [PubMed]
- Wick, G. Allowing an Open Discussion of the Side Effects of Vaccines. Available online: https://science.sciencemag.org/content/allowing-open-discussion-side-effects-vaccines (accessed on 8 June 2021).
Symptoms | Number of Cases | Frequency (%) |
---|---|---|
General fatigue | 73 | 83.9 |
Severe headache | 72 | 82.8 |
Widespread pain | 71 | 81.6 |
Dysautonomic symptoms | 71 | 81.6 |
Motor dysfunction | 56 | 64.4 |
Abnormal sensation | 52 | 59.8 |
Learning impairment | 52 | 59.8 |
Sleep disturbance | 44 | 50.6 |
Menstrual abnormality | 44 | 50.6 |
Limb shaking | 41 | 47.1 |
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Hineno, A.; Ikeda, S.-I. A Long-Term Observation on the Possible Adverse Effects in Japanese Adolescent Girls after Human Papillomavirus Vaccination. Vaccines 2021, 9, 856. https://doi.org/10.3390/vaccines9080856
Hineno A, Ikeda S-I. A Long-Term Observation on the Possible Adverse Effects in Japanese Adolescent Girls after Human Papillomavirus Vaccination. Vaccines. 2021; 9(8):856. https://doi.org/10.3390/vaccines9080856
Chicago/Turabian StyleHineno, Akiyo, and Shu-Ichi Ikeda. 2021. "A Long-Term Observation on the Possible Adverse Effects in Japanese Adolescent Girls after Human Papillomavirus Vaccination" Vaccines 9, no. 8: 856. https://doi.org/10.3390/vaccines9080856