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Article

Neutralizing Antibodies Titers and Side Effects in Response to BNT162b2 Vaccine in Healthcare Workers with and without Prior SARS-CoV-2 Infection

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Institute of Research in Biomedical Sciences, University Center of Health Sciences (CUCS), University of Guadalajara, Guadalajara 44340, Mexico
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Pediatric Service, Nuevo Hospital Civil de Guadalajara “Dr. Juan I. Menchaca”, University of Guadalajara, Guadalajara 44340, Mexico
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Programmed in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore
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Institute for Research on Cancer in Childhood and Adolescence, University Center of Health Sciences (CUCS), University of Guadalajara, Guadalajara 44340, Mexico
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Immunology Laboratory, University Center of Health Sciences (CUCS), University of Guadalajara, Guadalajara 44340, Mexico
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Allergy and Clinical Immunology Service, Nuevo Hospital Civil de Guadalajara “Dr. Juan I. Menchaca”, University of Guadalajara, Guadalajara 44340, Mexico
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University Center for Exact Sciences and Engineering (CUCEI), University of Guadalajara, Guadalajara 44340, Mexico
*
Authors to whom correspondence should be addressed.
Academic Editors: Tiziana Ramaci and Massimiliano Barattucci
Vaccines 2021, 9(7), 742; https://doi.org/10.3390/vaccines9070742
Received: 17 June 2021 / Revised: 2 July 2021 / Accepted: 3 July 2021 / Published: 5 July 2021
(This article belongs to the Special Issue SARS-CoV-2 (COVID-19) Vaccination and Compliance/Hesitancy)
The main expected result of a vaccine against viruses is the ability to produce neutralizing antibodies. Currently, several vaccines against SARS-CoV-2 are being applied to prevent mortal complications, being Pfizer-BioNTech (BNT162b2) one of the first to be authorized in the USA and Mexico (11 December 2020). This study evaluated the efficacy of this vaccine on antibody production with neutralizing capacity and its side effects in healthcare workers with and without prior SARS-CoV-2 infection and in a group of unvaccinated individuals with prior COVID-19. The main findings are the production of 100% neutralizing antibodies in both groups after the second dose, well-tolerated adverse effects, the possible presence of immunosenescence, and finally, we support that a single dose of this vaccine in individuals with prior COVID-19 would be sufficient to achieve an immunization comparable to people without prior COVID-19 with a complete vaccination program (2 doses). View Full-Text
Keywords: COVID-19; BNT162b2; neutralizing antibodies; vaccine side effects COVID-19; BNT162b2; neutralizing antibodies; vaccine side effects
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MDPI and ACS Style

Morales-Núñez, J.J.; Muñoz-Valle, J.F.; Meza-López, C.; Wang, L.-F.; Machado Sulbarán, A.C.; Torres-Hernández, P.C.; Bedolla-Barajas, M.; De la O-Gómez, B.; Balcázar-Félix, P.; Hernández-Bello, J. Neutralizing Antibodies Titers and Side Effects in Response to BNT162b2 Vaccine in Healthcare Workers with and without Prior SARS-CoV-2 Infection. Vaccines 2021, 9, 742. https://doi.org/10.3390/vaccines9070742

AMA Style

Morales-Núñez JJ, Muñoz-Valle JF, Meza-López C, Wang L-F, Machado Sulbarán AC, Torres-Hernández PC, Bedolla-Barajas M, De la O-Gómez B, Balcázar-Félix P, Hernández-Bello J. Neutralizing Antibodies Titers and Side Effects in Response to BNT162b2 Vaccine in Healthcare Workers with and without Prior SARS-CoV-2 Infection. Vaccines. 2021; 9(7):742. https://doi.org/10.3390/vaccines9070742

Chicago/Turabian Style

Morales-Núñez, José J., José F. Muñoz-Valle, Carlos Meza-López, Lin-Fa Wang, Andrea C. Machado Sulbarán, Paola C. Torres-Hernández, Martín Bedolla-Barajas, Brenda De la O-Gómez, Paulina Balcázar-Félix, and Jorge Hernández-Bello. 2021. "Neutralizing Antibodies Titers and Side Effects in Response to BNT162b2 Vaccine in Healthcare Workers with and without Prior SARS-CoV-2 Infection" Vaccines 9, no. 7: 742. https://doi.org/10.3390/vaccines9070742

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