Zika E Glycan Loop Region and Guillain–Barré Syndrome-Related Proteins: A Possible Molecular Mimicry to Be Taken in Account for Vaccine Development
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
Supplementary Materials
Author Contributions
Funding
Patent
Conflicts of Interest
Abbreviations
BeH819015 | Clinical isolate of ZIKV collected in Brazil in 2015 |
Cav1.2 | Calcium channel voltage-dependent L-type α-1C subunit |
GBS | Guillain–Barré Syndrome |
HSP70 12A | Heat Shock 70 kDa protein 12A |
MR766-NIID | Laboratory-adapted ZIKV strain isolated in Uganda in 1947 |
VDCC | Voltage-dependent calcium channel |
ZIKV | Zika Virus |
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Query Sequence | Substitutions Associated | Output |
---|---|---|
IVNDT | T152I/I156T | Calcium channel voltage-dependent L type α-1C subunit Heat Shock 70 kDa protein 12A Pecanexlike protein 2Cyclin-C Adhesion G-protein coupled receptor V1 Coagulation factor VIII HEAT repeat-containing protein 5B Sodium leak channel nonselective protein Hexokinase-1, -2, -3, HKDC1 |
DTGHE | I156T/Y158H | Macrophage colony-stimulating factor 1 Collagen and calcium-binding EGF domain-containing protein 1 Transcription factor COE1 Cytoplasmic FMR1-interacting protein 1 A disintegrin and metalloproteinase with thrombospondin motifs 2 Folliculin-interacting protein 1 Ubiquitin-associated protein 2-like Prolyl endopeptidaselike Adapter protein CIKS Dermokine Immunity-related GTPase family M protein Tyrosine-protein kinase ABL2 Zinc finger protein 491 Obscurin Protein prune homolog 2 Otogelin eIF-2-alpha kinase activator GCN1 BAH and coiled-coil domain-containing protein 1 Centrosome-associated protein CEP250 Supervillin Ankyrin-1 |
GRLSS | K283R/F285S | Pikachurin precursor Hamartin Ankyrin repeat and LEM domain-containing protein 2 Testis-expressed protein 10 GRB2-associated and regulator of MAPK protein 2 Low-density lipoprotein receptor-related protein 3 Ligand of Numb protein X 2 Synaptotagminlike protein 4 Chromodomain Y-like protein 2 Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial precursor Sodium- and chloride-dependent GABA transporter 2 Acetyl-CoA acetyltransferase, cytosolic ER membrane protein complex subunit 10 Histamine H4 receptor Protein GOLM2 Protein FAM83A Uncharacterized protein C9orf163 Uncharacterized protein C3orf18 Mucin-16 Obscurin Nesprin-1 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma E3 ubiquitin-protein ligase HERC2 Histone-lysine N-methyltransferase 2A Serine/threonine-protein kinase mTOR Myosin light chain kinase, smooth muscle |
VPAQM | I341V/V343A | Zinc finger protein 646, 292, 831, GLI1 Galactoside alpha-(1,2)-fucosyltransferase 2 Tensin-2 Neurolysin, mitochondrial Filamin-A Spectrin beta chain, nonerythrocytic 5 Structure-specific endonuclease subunit SLX4 Adhesion G protein-coupled receptor L3 Tau-tubulin kinase 1 IQ domain-containing protein N N-acetylglucosamine-1-phosphotransferase subunits alpha/beta FERM domain-containing protein 4A RE1-silencing transcription factor Protocadherin-8 Protein transport protein Sec24D Adhesion G-protein coupled receptor G2 Protein FAN Kinesinlike protein KIF18B |
GALNS | V437A/F438L | A-kinase anchor protein 12 EMILIN-1 precursor DENN domain-containing protein 1C Gelsolin Tudor domain-containing protein 10 CXXC-type zinc finger protein 4 Obscurin Microtubule-actin cross-linking factor 1 Usherin Ryanodine receptor 2 Dynein heavy chain 8, heavy chain 14, heavy chain 7 Sacsin Basement membrane-specific heparan sulfate proteoglycan core protein DNA-dependent protein kinase catalytic subunit Protein bassoon Transformation/transcription domain-associated protein Xin actin-binding repeat-containing protein 2 Protocadherin-16 precursor |
Start-End | Peptide |
---|---|
5–9 | GVSNR |
66–103 | SDMASDSRCPTQGEAYLDKQSDTQYVCKRTLVDRGWGN |
126–133 | TGKSIQPE |
146–163 | SQHSGMIVNDTGHETDEN |
193–197 | RTGLD |
218–240 | FHDIPLPWHAGADTGTPHWNNKE |
274–279 | EAEMDG |
312–322 | TFTKIPAETL |
349–352 | MQTL |
368–371 | STEN |
395–408 | KITHHWHRSGSTIG |
428–440 | AWDFGSVGGALNS |
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Lebeau, G.; Frumence, E.; Turpin, J.; Begue, F.; Hoarau, J.-J.; Gadea, G.; Krejbich-Trotot, P.; Desprès, P.; Viranaicken, W. Zika E Glycan Loop Region and Guillain–Barré Syndrome-Related Proteins: A Possible Molecular Mimicry to Be Taken in Account for Vaccine Development. Vaccines 2021, 9, 283. https://doi.org/10.3390/vaccines9030283
Lebeau G, Frumence E, Turpin J, Begue F, Hoarau J-J, Gadea G, Krejbich-Trotot P, Desprès P, Viranaicken W. Zika E Glycan Loop Region and Guillain–Barré Syndrome-Related Proteins: A Possible Molecular Mimicry to Be Taken in Account for Vaccine Development. Vaccines. 2021; 9(3):283. https://doi.org/10.3390/vaccines9030283
Chicago/Turabian StyleLebeau, Grégorie, Etienne Frumence, Jonathan Turpin, Floran Begue, Jean-Jacques Hoarau, Gilles Gadea, Pascale Krejbich-Trotot, Philippe Desprès, and Wildriss Viranaicken. 2021. "Zika E Glycan Loop Region and Guillain–Barré Syndrome-Related Proteins: A Possible Molecular Mimicry to Be Taken in Account for Vaccine Development" Vaccines 9, no. 3: 283. https://doi.org/10.3390/vaccines9030283
APA StyleLebeau, G., Frumence, E., Turpin, J., Begue, F., Hoarau, J.-J., Gadea, G., Krejbich-Trotot, P., Desprès, P., & Viranaicken, W. (2021). Zika E Glycan Loop Region and Guillain–Barré Syndrome-Related Proteins: A Possible Molecular Mimicry to Be Taken in Account for Vaccine Development. Vaccines, 9(3), 283. https://doi.org/10.3390/vaccines9030283