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Development of mRNA Vaccines: Scientific and Regulatory Issues

An Update on Self-Amplifying mRNA Vaccine Development

Michael Smith Laboratories, School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
Precision NanoSystems Inc., Vancouver, BC V6P 6T7, Canada
Author to whom correspondence should be addressed.
Academic Editor: Norbert Pardi
Vaccines 2021, 9(2), 97;
Received: 16 December 2020 / Revised: 21 January 2021 / Accepted: 23 January 2021 / Published: 28 January 2021
(This article belongs to the Special Issue The Past, Present, and Future of mRNA Vaccines)
This review will explore the four major pillars required for design and development of an saRNA vaccine: Antigen design, vector design, non-viral delivery systems, and manufacturing (both saRNA and lipid nanoparticles (LNP)). We report on the major innovations, preclinical and clinical data reported in the last five years and will discuss future prospects. View Full-Text
Keywords: RNA; self-amplifying RNA; replicon; vaccine; drug delivery RNA; self-amplifying RNA; replicon; vaccine; drug delivery
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MDPI and ACS Style

Blakney, A.K.; Ip, S.; Geall, A.J. An Update on Self-Amplifying mRNA Vaccine Development. Vaccines 2021, 9, 97.

AMA Style

Blakney AK, Ip S, Geall AJ. An Update on Self-Amplifying mRNA Vaccine Development. Vaccines. 2021; 9(2):97.

Chicago/Turabian Style

Blakney, Anna K., Shell Ip, and Andrew J. Geall 2021. "An Update on Self-Amplifying mRNA Vaccine Development" Vaccines 9, no. 2: 97.

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