Why It Is Important to Develop an Effective and Safe Pediatric COVID-19 Vaccine
2. Trials on COVID-19 Vaccines in Children
3. Why It Is Important to Develop a Pediatric COVID-19 Vaccine
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
- Conte, C.; Sogni, F.; Affanni, P.; Veronesi, L.; Argentiero, A.; Esposito, S. Vaccines against coronaviruses: The state of the art. Vaccines 2020, 8, 309. [Google Scholar] [CrossRef] [PubMed]
- STAT. Will Covid-19 Vaccines Be Safe for Children and Pregnant Women? The Data, So Far, Are Lacking. Available online: https://www.statnews.com/2020/08/19/will-covid-19-vaccines-be-safe-for-children-and-pregnant-women-the-data-so-far-are-lacking/ (accessed on 9 October 2020).
- U.S. Department of Health and Human Services Food and Drug Administration Center for Biologics Evaluation and Research. Development and Licensure of Vaccines to Prevent COVID-19. Guidance for Industry. Available online: https://www.fda.gov/media/139638/download (accessed on 9 October 2020).
- Viner, R.M.; Mytton, O.T.; Bonell, C.; Melendez-Torres, G.J.; Ward, J.; Hudson, L.; Waddington, C.; Thomas, J.; Russell, S.; Van Der Klis, F.; et al. Susceptibility to SARS-CoV-2 infection among children and adolescents compared with adults: A systematic review and meta-analysis. JAMA Pediatr. 2020. [Google Scholar] [CrossRef]
- Centers for Disease Control and Prevention. Coronavirus Disease 2019 (COVID-19). How CDC Is Making COVID-19 Vaccine Recommendations. Available online: https://www.cdc.gov/coronavirus/2019-ncov/vaccines/recommendations-process.html (accessed on 19 November 2020).
- Song, X.; Delaney, M.; Shah, R.K.; Campos, J.M.; Wessel, D.L.; De Biasi, R.L. Comparison of clinical features of COVID-19 vs. seasonal influenza A and B in US children. JAMA Netw. Open 2020, 3, e2020495. [Google Scholar] [CrossRef] [PubMed]
- American Academy of Pediatrics. Children and COVID-19: State-Level Data Report. Available online: https://services.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/children-and-covid-19-state-level-data-report/ (accessed on 9 October 2020).
- Kao, C.M.; Orenstein, W.A.; Anderson, E.J. The importance of advancing SARS-CoV-2 vaccines in children. Clin. Infect. Dis. 2020. [Google Scholar] [CrossRef]
- Principi, N.; Esposito, S. Influenza vaccine use to protect healthy children: A debated topic. Vaccine 2018, 36, 5391–5396. [Google Scholar] [CrossRef] [PubMed]
- Anastassopoulou, C.; Spanakis, N.; Tsakris, A. SARS-CoV-2 transmission, the ambiguous role of children and considerations for the reopening of schools in the fall. Future Microbiol. 2020, 5, 1201–1206. [Google Scholar] [CrossRef] [PubMed]
- Park, Y.J.; Choe, Y.J.; Park, O.; Park, S.Y.; Kim, Y.M.; Kim, J.; Kweon, S.; Woo, Y.; Gwack, J.; Kim, S.S.; et al. Contact tracing during coronavirus disease outbreak, South Korea. Emerg. Infect. Dis. 2020, 26, 2465–2468. [Google Scholar] [CrossRef] [PubMed]
- The Guardian. ‘Not a Game’: Europe Pleads with Young People to Halt Covid-19 Spread. Available online: https://www.theguardian.com/world/2020/sep/08/how-europe-is-tackling-spread-of-covid-19-with-appeal-to-young-people (accessed on 19 November 2020).
- Esposito, S.; Principi, N.; ESCMID Vaccine Study Group. Direct and indirect effects of the 13-valent pneumococcal conjugate vaccine administered to infants and young children. Future Microbiol. 2015, 10, 1599–1607. [Google Scholar] [CrossRef] [PubMed]
- World Health Organization. Pulse Survey on Continuity of Essential Health Services during the COVID-19 Pandemic. Available online: File:///C:/Users/PrincipiN/Downloads/WHO-2019-nCoV-EHS_continuity-survey-2020.1-eng.pdf (accessed on 9 October 2020).
- Simon, A.K.; Hollander, G.A.; McMichael, A. Evolution of the immune system in humans from infancy to old age. Proc. Biol. Sci. 2015, 282, 20143085. [Google Scholar] [CrossRef] [PubMed]
- Burke, R.M.; Tate, J.E.; Kirkwood, C.D.; Steele, A.D.; Parashar, U.D. Current and new rotavirus vaccines. Curr. Opin. Infect. Dis. 2019, 32, 435–444. [Google Scholar] [CrossRef] [PubMed]
- Kapikian, A.Z.; Mitchell, R.H.; Chanock, R.M.; Shvedoff, R.A.; Stewart, C.E. An epidemiologic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccine. Am. J. Epidemiol. 1969, 89, 405–421. [Google Scholar] [CrossRef] [PubMed]
- Xia, S.; Duan, K.; Zhang, Y.; Zhao, D.; Zhang, H.; Xie, Z.; Li, X.; Peng, C.; Zhang, Y.; Zhang, W.; et al. Effect of an inactivated vaccine against SARS-CoV-2 on safety and immunogenicity outcomes: Interim analysis of 2 randomized clinical trials. JAMA 2020, 324, 1–10. [Google Scholar] [CrossRef] [PubMed]
- Zeichner, S.L.; Cruz, A.T. Multisystem inflammatory syndrome in children and SARSCoV2 serology. Pediatrics 2020. [Google Scholar] [CrossRef]
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Principi, N.; Esposito, S. Why It Is Important to Develop an Effective and Safe Pediatric COVID-19 Vaccine. Vaccines 2021, 9, 127. https://doi.org/10.3390/vaccines9020127
Principi N, Esposito S. Why It Is Important to Develop an Effective and Safe Pediatric COVID-19 Vaccine. Vaccines. 2021; 9(2):127. https://doi.org/10.3390/vaccines9020127Chicago/Turabian Style
Principi, Nicola, and Susanna Esposito. 2021. "Why It Is Important to Develop an Effective and Safe Pediatric COVID-19 Vaccine" Vaccines 9, no. 2: 127. https://doi.org/10.3390/vaccines9020127