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Antibody Focusing to Conserved Sites of Vulnerability: The Immunological Pathways for ‘Universal’ Influenza Vaccines

The Ragon Institute of MGH, MIT, and Harvard, 400 Technology Square, Cambridge, MA 02139, USA
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Academic Editor: Yoichi Furuya
Vaccines 2021, 9(2), 125; https://doi.org/10.3390/vaccines9020125
Received: 11 January 2021 / Revised: 2 February 2021 / Accepted: 2 February 2021 / Published: 5 February 2021
Influenza virus remains a serious public health burden due to ongoing viral evolution. Vaccination remains the best measure of prophylaxis, yet current seasonal vaccines elicit strain-specific neutralizing responses that favor the hypervariable epitopes on the virus. This necessitates yearly reformulations of seasonal vaccines, which can be limited in efficacy and also shortchange pandemic preparedness. Universal vaccine development aims to overcome these deficits by redirecting antibody responses to functionally conserved sites of viral vulnerability to enable broad coverage. However, this is challenging as such antibodies are largely immunologically silent, both following vaccination and infection. Defining and then overcoming the immunological basis for such subdominant or ‘immuno-recessive’ antibody targeting has thus become an important aspect of universal vaccine development. This, coupled with structure-guided immunogen design, has led to proof-of-concept that it is possible to rationally refocus humoral immunity upon normally ‘unseen’ broadly neutralizing antibody targets on influenza virus. View Full-Text
Keywords: influenza virus; antibody response; universal vaccine; immunodominance; broadly neutralizing antibodies; B cell immunology influenza virus; antibody response; universal vaccine; immunodominance; broadly neutralizing antibodies; B cell immunology
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MDPI and ACS Style

Sangesland, M.; Lingwood, D. Antibody Focusing to Conserved Sites of Vulnerability: The Immunological Pathways for ‘Universal’ Influenza Vaccines. Vaccines 2021, 9, 125. https://doi.org/10.3390/vaccines9020125

AMA Style

Sangesland M, Lingwood D. Antibody Focusing to Conserved Sites of Vulnerability: The Immunological Pathways for ‘Universal’ Influenza Vaccines. Vaccines. 2021; 9(2):125. https://doi.org/10.3390/vaccines9020125

Chicago/Turabian Style

Sangesland, Maya, and Daniel Lingwood. 2021. "Antibody Focusing to Conserved Sites of Vulnerability: The Immunological Pathways for ‘Universal’ Influenza Vaccines" Vaccines 9, no. 2: 125. https://doi.org/10.3390/vaccines9020125

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