Next Article in Journal
Advancements in mRNA Encoded Antibodies for Passive Immunotherapy
Next Article in Special Issue
Antibody Focusing to Conserved Sites of Vulnerability: The Immunological Pathways for ‘Universal’ Influenza Vaccines
Previous Article in Journal
Maternal Autogenous Inactivated Virus Vaccination Boosts Immunity to PRRSV in Piglets
Previous Article in Special Issue
Adjuvant Selection for Influenza and RSV Prefusion Subunit Vaccines
Article

Elderly Subjects Supplemented with L-Glutamine Shows an Improvement of Mucosal Immunity in the Upper Airways in Response to Influenza Virus Vaccination

1
Department of Otorhinolaryngology, ENT Lab, Federal University of São Paulo (UNIFESP), São Paulo 04021-001, Brazil
2
Method Faculty of São Paulo (FAMESP), São Paulo 04046-200, Brazil
3
Department of Medicine, Geriatry, Paulista School of Medicine (EPM), São Paulo 04023-062, Brazil
4
Post-Graduation Program in Health Science, Santo Amaro University (UNISA), São Paulo 04743-030, Brazil
5
Institute of Biomedical Science, University of São Paulo (USP), São Paulo 05508-060, Brazil
6
Scientific Platform Pasteur, University of São Paulo (USP), São Paulo 05508-060, Brazil
7
Hospital Israelita Albert Einstein, São Paulo 05652-900, Brazil
8
Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), São Paulo 12245-520, Brazil
9
Post-Graduation Program in Bioengineering and Biomedical Engineering, Universidade Brasil, São Paulo 15600-000, Brazil
10
Post-Graduation Program in Science of Human and Rehabilitation, Federal University of São Paulo (UNIFESP), Santos 11015-020, Brazil
*
Author to whom correspondence should be addressed.
Academic Editors: Yoichi Furuya and Danushka Wijesundara
Vaccines 2021, 9(2), 107; https://doi.org/10.3390/vaccines9020107
Received: 16 December 2020 / Revised: 26 January 2021 / Accepted: 27 January 2021 / Published: 31 January 2021
Background: Although glutamine is able to improve the immune response, its action in the upper airway immunity against the influenza virus vaccine remains unclear. Therefore, we aimed to evaluate the L-glutamine supplementation effect on the mucosal immune/inflammatory response of elderly subjects vaccinated against the influenza virus. Methods: Saliva sampling from 83 physically active elderly volunteers were collected pre- and 30 days after influenza virus vaccination and supplementation with L-glutamine (Gln, n = 42) or placebo (PL, n = 41). Results: Gln group showed higher salivary levels of interleukin (IL)-17, total secretory immunoglobulin A (SIgA), and specific-SIgA post-vaccination than values found pre-vaccination and in the PL group post-vaccination. Whereas higher salivary levels of IL-6 and IL-10 were observed post-vaccination in the Gln group, IL-37 levels were lower post-vaccination in both groups than the values pre-vaccination. Tumor necrosis factor (TNF)-α levels were unchanged. Positive correlations between IL-6 and IL-10 were found in all volunteer groups pre- and post-vaccination and also between IL-17 and IL-6 or IL-10 in the Gln group post-vaccination. A negative correlation between IL-37 and IL-10 was found pre- and post-vaccination in the PL group. Conclusion: Gln supplementation was able to modulate salivary cytokine profile and increase SIgA levels, both total and specific to the influenza virus vaccine, in physically active elderly subjects. View Full-Text
Keywords: L-glutamine; influenza virus; vaccine; antibodies; immunoglobulin; cytokines L-glutamine; influenza virus; vaccine; antibodies; immunoglobulin; cytokines
Show Figures

Figure 1

MDPI and ACS Style

Paixão, V.; Almeida, E.B.; Amaral, J.B.; Roseira, T.; Monteiro, F.R.; Foster, R.; Sperandio, A.; Rossi, M.; Amirato, G.R.; Santos, C.A.F.; Pires, R.S.; Leal, F.B.; Durigon, E.L.; Oliveira, D.B.L.; Vieira, R.P.; Vaisberg, M.; Santos, J.M.B.; Bachi, A.L.L. Elderly Subjects Supplemented with L-Glutamine Shows an Improvement of Mucosal Immunity in the Upper Airways in Response to Influenza Virus Vaccination. Vaccines 2021, 9, 107. https://doi.org/10.3390/vaccines9020107

AMA Style

Paixão V, Almeida EB, Amaral JB, Roseira T, Monteiro FR, Foster R, Sperandio A, Rossi M, Amirato GR, Santos CAF, Pires RS, Leal FB, Durigon EL, Oliveira DBL, Vieira RP, Vaisberg M, Santos JMB, Bachi ALL. Elderly Subjects Supplemented with L-Glutamine Shows an Improvement of Mucosal Immunity in the Upper Airways in Response to Influenza Virus Vaccination. Vaccines. 2021; 9(2):107. https://doi.org/10.3390/vaccines9020107

Chicago/Turabian Style

Paixão, Vitória, Ewin B. Almeida, Jonatas B. Amaral, Tamaris Roseira, Fernanda R. Monteiro, Roberta Foster, Adriane Sperandio, Marcelo Rossi, Gislene R. Amirato, Carlos A.F. Santos, Renier S. Pires, Fabyano B. Leal, Edison L. Durigon, Danielle B.L. Oliveira, Rodolfo P. Vieira, Mauro Vaisberg, Juliana M.B. Santos, and André L.L. Bachi. 2021. "Elderly Subjects Supplemented with L-Glutamine Shows an Improvement of Mucosal Immunity in the Upper Airways in Response to Influenza Virus Vaccination" Vaccines 9, no. 2: 107. https://doi.org/10.3390/vaccines9020107

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop