VLP-Based COVID-19 Vaccines: An Adaptable Technology against the Threat of New Variants
Abstract
:1. Introduction
2. SARS-CoV-2, VOCs, and Structural Vaccinology
3. Enveloped VLPs against SARS-CoV-2
4. Non-Enveloped VLPs against SARS-CoV-2
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Name | Platform | Adjuvant | Dosage | Efficacy * | References |
---|---|---|---|---|---|
Coronavac (Sinovac) | Inactivated | Alum | 2 doses | 83.5% (95% CI, 65.4–92.1) | [8,9,10,11] |
BBIBP-CorV (Sinopharm) | Inactivated | Alum | 2 doses | 72.8% (95% CI, 58.1–82.4) | [12,13] |
BBV152-Covaxin (Bharat Biotech) | Inactivated | Alum | 2 doses | 77.8% (95% CI, 65.2–86.4) | [14,15] |
AZD1222–Vaxzevria (Oxford/AstraZeneca) | Viral vector | No | 2 doses | 74.0% (95% CI, 65.3–80.5) | [16,17,18] |
Covishield (Oxford/AstraZeneca formulation) | Viral vector | No | 2 doses | 74.0% (95% CI, 65.3–80.5) | [16,17,18] |
Ad26.COV2.S (Johnson &Johnson-Janssen) | Viral vector | No | 1 dose | 66.9% (95% CI, 59.0–73.4) | [19,20,21,22] |
mRNA-1273 (Moderna) | mRNA | No | 2 doses | 94.1% (95% CI, 89.3–96.8) | [23,24] |
BNT162b-Comirnaty (Pfizer/BioNTech) | mRNA | No | 2 doses | 95% (95% CI, 90.3–97.6) | [25,26] |
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Prates-Syed, W.A.; Chaves, L.C.S.; Crema, K.P.; Vuitika, L.; Lira, A.; Côrtes, N.; Kersten, V.; Guimarães, F.E.G.; Sadraeian, M.; Barroso da Silva, F.L.; Cabral-Marques, O.; Barbuto, J.A.M.; Russo, M.; Câmara, N.O.S.; Cabral-Miranda, G. VLP-Based COVID-19 Vaccines: An Adaptable Technology against the Threat of New Variants. Vaccines 2021, 9, 1409. https://doi.org/10.3390/vaccines9121409
Prates-Syed WA, Chaves LCS, Crema KP, Vuitika L, Lira A, Côrtes N, Kersten V, Guimarães FEG, Sadraeian M, Barroso da Silva FL, Cabral-Marques O, Barbuto JAM, Russo M, Câmara NOS, Cabral-Miranda G. VLP-Based COVID-19 Vaccines: An Adaptable Technology against the Threat of New Variants. Vaccines. 2021; 9(12):1409. https://doi.org/10.3390/vaccines9121409
Chicago/Turabian StylePrates-Syed, Wasim A., Lorena C. S. Chaves, Karin P. Crema, Larissa Vuitika, Aline Lira, Nelson Côrtes, Victor Kersten, Francisco E. G. Guimarães, Mohammad Sadraeian, Fernando L. Barroso da Silva, Otávio Cabral-Marques, José A. M. Barbuto, Momtchilo Russo, Niels O. S. Câmara, and Gustavo Cabral-Miranda. 2021. "VLP-Based COVID-19 Vaccines: An Adaptable Technology against the Threat of New Variants" Vaccines 9, no. 12: 1409. https://doi.org/10.3390/vaccines9121409