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Volume 8
Issue 4
10.3390/vaccines8040765
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Article

Virus-Like Particle Based Vaccines Elicit Neutralizing Antibodies against the HIV-1 Fusion Peptide

by
Alemu Tekewe Mogus
1,
Lihong Liu
2,3,
Manxue Jia
2,
Diane T. Ajayi
1,
Kai Xu
4,
Rui Kong
4,
Jing Huang
2,3,
Jian Yu
2,3,
Peter D. Kwong
4,
John R. Mascola
4,
David D. Ho
2,3,
Moriya Tsuji
2,3,* and
Bryce Chackerian
1,*
1
Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM 87131, USA
2
Aaron Diamond AIDS Research Center, New York, NY 10016, USA
3
Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA
4
Vaccine Research Center, NIAID, NIH, 40 Convent Drive, Bethesda, MD 20892, USA
*
Authors to whom correspondence should be addressed.
Vaccines 2020, 8(4), 765; https://doi.org/10.3390/vaccines8040765
Received: 4 November 2020 / Revised: 11 December 2020 / Accepted: 11 December 2020 / Published: 15 December 2020
(This article belongs to the Special Issue HIV Vaccine)
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Abstract

Broadly neutralizing antibodies (bnAbs) isolated from HIV-infected individuals delineate vulnerable sites on the HIV envelope glycoprotein that are potential vaccine targets. A linear epitope within the N-terminal region of the HIV-1 fusion peptide (FP8) is the primary target of VRC34.01, a bnAb that neutralizes ~50% of primary HIV isolates. FP8 has attracted attention as a potential HIV vaccine target because it is a simple linear epitope. Here, platform technologies based on RNA bacteriophage virus-like particles (VLPs) were used to develop multivalent vaccines targeting the FP8 epitope. Both recombinant MS2 VLPs displaying the FP8 peptide and Qβ VLPs displaying chemically conjugated FP8 peptide induced high titers of FP8-specific antibodies in mice. Moreover, a heterologous prime-boost-boost regimen employing the two FP8-VLP vaccines and native envelope trimer was the most effective approach for eliciting HIV-1 neutralizing antibodies. Given the potent immunogenicity of VLP-based vaccines, this vaccination strategy—inspired by bnAb-guided epitope mapping, VLP bioengineering, and prime-boost immunization approaches—may be a useful strategy for eliciting bnAb responses against HIV. View Full-Text
Keywords: broadly neutralizing antibody; HIV-1 fusion peptide; HIV-1 DS-SOSIP trimer; prime-boost immunizations; vaccine; virus-like particles broadly neutralizing antibody; HIV-1 fusion peptide; HIV-1 DS-SOSIP trimer; prime-boost immunizations; vaccine; virus-like particles
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MDPI and ACS Style

Mogus, A.T.; Liu, L.; Jia, M.; Ajayi, D.T.; Xu, K.; Kong, R.; Huang, J.; Yu, J.; Kwong, P.D.; Mascola, J.R.; Ho, D.D.; Tsuji, M.; Chackerian, B. Virus-Like Particle Based Vaccines Elicit Neutralizing Antibodies against the HIV-1 Fusion Peptide. Vaccines 2020, 8, 765. https://doi.org/10.3390/vaccines8040765

AMA Style

Mogus AT, Liu L, Jia M, Ajayi DT, Xu K, Kong R, Huang J, Yu J, Kwong PD, Mascola JR, Ho DD, Tsuji M, Chackerian B. Virus-Like Particle Based Vaccines Elicit Neutralizing Antibodies against the HIV-1 Fusion Peptide. Vaccines. 2020; 8(4):765. https://doi.org/10.3390/vaccines8040765

Chicago/Turabian Style

Mogus, Alemu Tekewe, Lihong Liu, Manxue Jia, Diane T. Ajayi, Kai Xu, Rui Kong, Jing Huang, Jian Yu, Peter D. Kwong, John R. Mascola, David D. Ho, Moriya Tsuji, and Bryce Chackerian. 2020. "Virus-Like Particle Based Vaccines Elicit Neutralizing Antibodies against the HIV-1 Fusion Peptide" Vaccines 8, no. 4: 765. https://doi.org/10.3390/vaccines8040765

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