Next Article in Journal
Nitric Oxide Production and Fc Receptor-Mediated Phagocytosis as Functional Readouts of Macrophage Activity upon Stimulation with Inactivated Poultry Vaccines In Vitro
Next Article in Special Issue
Grippenet: A New Tool for the Monitoring, Risk-Factor and Vaccination Coverage Analysis of Influenza-Like Illness in Switzerland
Previous Article in Journal
Limited Cross-Protection against Infectious Bronchitis Provided by Recombinant Infectious Bronchitis Viruses Expressing Heterologous Spike Glycoproteins
Previous Article in Special Issue
Trends, Coverage and Influencing Determinants of Influenza Vaccination in the Elderly: A Population-Based National Survey in Spain (2006–2017)
Open AccessCommunication

Risk Assessment and Virological Monitoring Following an Accidental Exposure to Concentrated Sabin Poliovirus Type 3 in France, November 2018

1
Centre National de Référence des Entérovirus et Parechovirus, WHO National Poliovirus Laboratory, Institut des Agents Infectieux, Groupement Hospitalier Nord, Hospices Civils de Lyon, 69317 Lyon, France
2
Santé publique France, 94410 Saint Maurice, France
3
Public Health Emergency Operations Centre, Division of Surveillance and Health Security, General Directorate for Health, Ministry of Solidarity and Health, 75350 Paris, France
4
Laboratoire Virpath, Centre International de Recherche en Infectiologie (CIRI), Université de Lyon, Inserm U1111, CNRS UMR 5308, ENS de Lyon, UCBL, 69372 Lyon, France
*
Author to whom correspondence should be addressed.
Vaccines 2020, 8(2), 331; https://doi.org/10.3390/vaccines8020331
Received: 9 June 2020 / Revised: 19 June 2020 / Accepted: 19 June 2020 / Published: 22 June 2020
The safe and secure containment of infectious poliovirus (PV) in facilities where live PV are handled is the condition to achieve and maintain poliomyelitis eradication. Despite precautions to minimize the risk of release of PV from such facilities to the environment, breaches of containment have already been documented. Here, we report the management of an incident that occurred on 30 November 2018 in a French vaccine manufacturing plant. Five adequately vaccinated operators were exposed to a Sabin poliovirus type 3 (PV3) spill. A microbiological risk assessment was conducted and the operators were monitored for PV shedding. On day 5 after exposure, Sabin PV3 was detected only in the stool sample of the most exposed worker. Shedding of Sabin PV3 (as detected by viral culture) was restricted to a very short period (less than 15 days). Monitoring of this incident was an opportunity to assess the relevance of our national response plan. We concluded that the measures undertaken and reported here were appropriate and proportional. View Full-Text
Keywords: poliovirus; incident; accident; risk assessment; containment breach; GAP III poliovirus; incident; accident; risk assessment; containment breach; GAP III
Show Figures

Figure 1

MDPI and ACS Style

Jeannoël, M.; Antona, D.; Lazarus, C.; Lina, B.; Schuffenecker, I. Risk Assessment and Virological Monitoring Following an Accidental Exposure to Concentrated Sabin Poliovirus Type 3 in France, November 2018. Vaccines 2020, 8, 331.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop