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Innate Immune Receptors and Defense Against Primary Pathogenic Fungi

1
Division of Infectious Diseases, Departments of Pathology and Medicine, School of Medicine, University of California San Diego, San Diego, CA 92037, USA
2
VA HealthCare San Diego, San Diego, CA 92161, USA
*
Author to whom correspondence should be addressed.
Vaccines 2020, 8(2), 303; https://doi.org/10.3390/vaccines8020303
Received: 16 May 2020 / Revised: 10 June 2020 / Accepted: 11 June 2020 / Published: 13 June 2020
The innate immune system is critical for natural resistance to all pathogenic microorganisms, including fungi. The innate response plays a vital role in resistance to infections before the antigen-specific immune response and also influences antigen-specific adaptive immunity. There are many different receptors for the innate immune response to fungi, and some receptors have been found to play a significant role in the response to human infections with opportunistic fungi. Most human infections are caused by opportunistic fungi, but a small number of organisms are capable of causing infections in normal hosts. The primary pathogenic fungi that cause invasive infections include Blastomyces spp., Cryptococcus gattii, Coccidioides spp., Histoplasma spp., and Paracoccidioides spp. In this review of innate immune receptors that play a role in infections caused by these organisms, we find that innate immunity differs between organisms. View Full-Text
Keywords: innate immunity; receptors; fungi; pathogenic fungi; microbial immunity; CLR; TLR innate immunity; receptors; fungi; pathogenic fungi; microbial immunity; CLR; TLR
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Kirkland, T.N.; Fierer, J. Innate Immune Receptors and Defense Against Primary Pathogenic Fungi. Vaccines 2020, 8, 303.

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