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Open AccessArticle

The Potential of Influenza HA-Specific Immunity in Mitigating Lethality of Postinfluenza Pneumococcal Infections

1
Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU), 1190 Vienna, Austria
2
Department of Virology, I. Mechnikov Research Institute for Vaccines and Sera, Moscow 105064, Russia
3
Smorodintsev Research Institute of Influenza, St. Petersburg 197376, Russia
4
Department of Microbiology, I. Mechnikov Research Institute for Vaccines and Sera, Moscow 105064, Russia
*
Authors to whom correspondence should be addressed.
Vaccines 2019, 7(4), 187; https://doi.org/10.3390/vaccines7040187
Received: 4 October 2019 / Revised: 9 November 2019 / Accepted: 11 November 2019 / Published: 17 November 2019
(This article belongs to the Section Influenza Virus Vaccines)
Influenza virus infections pre-dispose an individual to secondary pneumococcal infections, which represent a serious public health concern. Matching influenza vaccination was demonstrated helpful in preventing postinfluenza bacterial infections and associated illnesses in humans. Yet, the impact of influenza hemagglutinin (HA)-specific immunity alone in this dual-infection scenario remains elusive. In the present study, we assessed the protective effect of neutralizing and non-neutralizing anti-hemagglutinin immunity in a BALB/c influenza-pneumococcus superinfection model. Our immunogens were insect cell-expressed hemagglutinin-Gag virus-like particles that had been differentially-treated for the inactivation of bioprocess-related baculovirus impurities. We evaluated the potential of several formulations to restrain the primary infection with vaccine-matched or -mismatched influenza strains and secondary bacterial replication. In addition, we investigated the effect of anti-HA immunity on the interferon status in mouse lungs prior to bacterial challenge. In our experimental setup, neutralizing anti-HA immunity provided significant but incomplete protection from postinfluenza bacterial superinfection, despite effective control of viral replication. In view of this, it was surprising to observe a survival advantage with non-neutralizing adaptive immunity when using a heterologous viral challenge strain. Our findings suggest that both neutralizing and non-neutralizing anti-HA immunity can reduce disease and mortality caused by postinfluenza pneumococcal infections. View Full-Text
Keywords: Influenza; Streptococcus pneumoniae; secondary bacterial infection; off-target vaccine effects; anti-HA immunity; type I/II interferon; VLP vaccine; baculovirus inactivation Influenza; Streptococcus pneumoniae; secondary bacterial infection; off-target vaccine effects; anti-HA immunity; type I/II interferon; VLP vaccine; baculovirus inactivation
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MDPI and ACS Style

Klausberger, M.; Leneva, I.A.; Falynskova, I.N.; Vasiliev, K.; Poddubikov, A.V.; Lindner, C.; Kartaschova, N.P.; Svitich, O.A.; Stukova, M.; Grabherr, R.; Egorov, A. The Potential of Influenza HA-Specific Immunity in Mitigating Lethality of Postinfluenza Pneumococcal Infections. Vaccines 2019, 7, 187. https://doi.org/10.3390/vaccines7040187

AMA Style

Klausberger M, Leneva IA, Falynskova IN, Vasiliev K, Poddubikov AV, Lindner C, Kartaschova NP, Svitich OA, Stukova M, Grabherr R, Egorov A. The Potential of Influenza HA-Specific Immunity in Mitigating Lethality of Postinfluenza Pneumococcal Infections. Vaccines. 2019; 7(4):187. https://doi.org/10.3390/vaccines7040187

Chicago/Turabian Style

Klausberger, Miriam; Leneva, Irina A.; Falynskova, Irina N.; Vasiliev, Kirill; Poddubikov, Alexander V.; Lindner, Claudia; Kartaschova, Nadezhda P.; Svitich, Oxana A.; Stukova, Marina; Grabherr, Reingard; Egorov, Andrej. 2019. "The Potential of Influenza HA-Specific Immunity in Mitigating Lethality of Postinfluenza Pneumococcal Infections" Vaccines 7, no. 4: 187. https://doi.org/10.3390/vaccines7040187

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